TY - JOUR
T1 - Anti-inflammatory treatment and risk of depression in 91,842 patients with acute coronary syndrome and 91,860 individuals without acute coronary syndrome in Denmark
AU - Wium-Andersen, Ida Kim
AU - Wium-Andersen, Marie Kim
AU - Jørgensen, Martin Balslev
AU - Osler, Merete
PY - 2017
Y1 - 2017
N2 - Background We examined if treatment with acetylsalicylic acid (ASA), non-steroid anti-inflammatory drugs (NSAID), or statins after acute coronary syndrome (ACS) are associated with decreased risk of depression. Method This register-based cohort study included all individuals with a first-time hospital admissions with an ACS diagnosis registered between January 2001 to December 2009 (N = 91,842) and a comparable reference population without ACS (N = 91,860). Information of ASA, NSAID, and statin use were retrieved from a national prescription register. The study population was followed for hospitalization with depression or receiving prescription of antidepressant medication for up to one year after ACS or study entry (early depression) or one to twelve years after ACS or study entry (late depression). Results ASA use after ACS was associated with decreased risk of early depression with hazard ratios (HR) of 0.89 (95% confidence interval 0.85–0.93) but not with late depression 0.96 (0.90–1.01). The corresponding HRs for statin were 0.90 (0.86–0.94) and 0.86 (0.82–0.90). In the non-ACS population, statin use was not associated with neither early nor late depression (HRs 1.04 (0.96–1.12) and 1.00 (0.95–1.06)), while ASA was associated with increased risk of late (HR 1.09 (1.04–1.14)) but not early depression (HR 1.03 (0.97–1.09)). In both populations, NSAID use was associated with increased risk of late but not early depression. Conclusion Use of ASA or statins were associated with decreased risk of depression in ACS patients but not in individuals without ACS, while use of NSAID was associated with increased risk of late depression in both populations.
AB - Background We examined if treatment with acetylsalicylic acid (ASA), non-steroid anti-inflammatory drugs (NSAID), or statins after acute coronary syndrome (ACS) are associated with decreased risk of depression. Method This register-based cohort study included all individuals with a first-time hospital admissions with an ACS diagnosis registered between January 2001 to December 2009 (N = 91,842) and a comparable reference population without ACS (N = 91,860). Information of ASA, NSAID, and statin use were retrieved from a national prescription register. The study population was followed for hospitalization with depression or receiving prescription of antidepressant medication for up to one year after ACS or study entry (early depression) or one to twelve years after ACS or study entry (late depression). Results ASA use after ACS was associated with decreased risk of early depression with hazard ratios (HR) of 0.89 (95% confidence interval 0.85–0.93) but not with late depression 0.96 (0.90–1.01). The corresponding HRs for statin were 0.90 (0.86–0.94) and 0.86 (0.82–0.90). In the non-ACS population, statin use was not associated with neither early nor late depression (HRs 1.04 (0.96–1.12) and 1.00 (0.95–1.06)), while ASA was associated with increased risk of late (HR 1.09 (1.04–1.14)) but not early depression (HR 1.03 (0.97–1.09)). In both populations, NSAID use was associated with increased risk of late but not early depression. Conclusion Use of ASA or statins were associated with decreased risk of depression in ACS patients but not in individuals without ACS, while use of NSAID was associated with increased risk of late depression in both populations.
KW - Acetylsalicylic acid
KW - Acute coronary syndrome
KW - Anti-inflammatory treatment
KW - Depression
KW - NSAID
KW - Statin
U2 - 10.1016/j.ijcard.2017.05.105
DO - 10.1016/j.ijcard.2017.05.105
M3 - Journal article
C2 - 28867006
AN - SCOPUS:85028548889
SN - 0167-5273
VL - 246
SP - 1
EP - 6
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -