Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men: A randomized controlled trial

Anne Sofie Gram; Else-Marie Bladbjerg; Jonas Salling Quist; Martin Bæk Petersen; Mads Rosenkilde; Bente Stallknecht

doi:10.1016/j.atherosclerosis.2017.06.923

Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men: A randomized controlled trial

Anne Sofie Gram, Else-Marie Bladbjerg, Jonas Salling Quist, Martin Bæk Petersen, Mads Rosenkilde, Bente Stallknecht

14 Citations (Scopus)

Abstract

BACKGROUND AND AIMS: Physical inactivity is linked to low-grade inflammation, endothelial dysfunction and cardiovascular disease. We aimed to determine effects of active commuting and leisure time exercise on markers of low-grade inflammation and endothelial function in overweight and obese women and men.

METHODS: We randomized 130 younger (20-45 years), physically inactive, healthy, overweight and obese (BMI: 25-35 kg/m2) women and men recruited from the Copenhagen area, Denmark, to either 6 months of habitual lifestyle (CON, n = 18), active commuting (BIKE, n = 35), or leisure time exercise of moderate (MOD, ∼50% VO2peak, n = 39) or vigorous intensity (VIG, ∼70% VO2peak, n = 38). Fasting blood samples were collected at baseline, 3, and 6 months and analyzed for concentrations of C-reactive protein (CRP), fibrinogen, von Willebrand factor (vWF), tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor type 1 (PAI-1), and 90 participants (CON, n = 16; BIKE, n = 19; MOD, n = 31, VIG, n = 24) were included in a per-protocol analysis.

RESULTS: We observed lower concentrations of CRP in MOD compared with CON at 6 months (p = 0.013) and within-group decreases in CRP in BIKE (3 months: p = 0.045) and MOD (3 months: p = 0.061; 6 months: p = 0.038) corresponding to a 30% decrease in BIKE and 19% in MOD from baseline till 6 months. No effects of exercise were observed on fibrinogen, vWF, t-PA, PAI-1 or the t-PA/PAI-1 ratio within or between groups.

CONCLUSIONS: Our findings suggest an anti-inflammatory effect of active commuting and moderate, but not vigorous, intensity leisure time exercise, but no alterations in endothelial function during 6 months of intervention.

Original language	English
Journal	Atherosclerosis
Volume	265
Pages (from-to)	318-324
Number of pages	7
ISSN	0021-9150
DOIs	https://doi.org/10.1016/j.atherosclerosis.2017.06.923
Publication status	Published - Oct 2017

Keywords

Adult
Exercise
Female
Humans
Inflammation/etiology
Leisure Activities
Male
Middle Aged
Obesity/complications
Overweight/complications
Transportation
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.atherosclerosis.2017.06.923

Cite this

@article{3e3d86e3c81f43de95fa533f04ee8dee,

title = "Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men: A randomized controlled trial",

abstract = "BACKGROUND AND AIMS: Physical inactivity is linked to low-grade inflammation, endothelial dysfunction and cardiovascular disease. We aimed to determine effects of active commuting and leisure time exercise on markers of low-grade inflammation and endothelial function in overweight and obese women and men.METHODS: We randomized 130 younger (20-45 years), physically inactive, healthy, overweight and obese (BMI: 25-35 kg/m2) women and men recruited from the Copenhagen area, Denmark, to either 6 months of habitual lifestyle (CON, n = 18), active commuting (BIKE, n = 35), or leisure time exercise of moderate (MOD, ∼50% VO2peak, n = 39) or vigorous intensity (VIG, ∼70% VO2peak, n = 38). Fasting blood samples were collected at baseline, 3, and 6 months and analyzed for concentrations of C-reactive protein (CRP), fibrinogen, von Willebrand factor (vWF), tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor type 1 (PAI-1), and 90 participants (CON, n = 16; BIKE, n = 19; MOD, n = 31, VIG, n = 24) were included in a per-protocol analysis.RESULTS: We observed lower concentrations of CRP in MOD compared with CON at 6 months (p = 0.013) and within-group decreases in CRP in BIKE (3 months: p = 0.045) and MOD (3 months: p = 0.061; 6 months: p = 0.038) corresponding to a 30% decrease in BIKE and 19% in MOD from baseline till 6 months. No effects of exercise were observed on fibrinogen, vWF, t-PA, PAI-1 or the t-PA/PAI-1 ratio within or between groups.CONCLUSIONS: Our findings suggest an anti-inflammatory effect of active commuting and moderate, but not vigorous, intensity leisure time exercise, but no alterations in endothelial function during 6 months of intervention.",

keywords = "Adult, Exercise, Female, Humans, Inflammation/etiology, Leisure Activities, Male, Middle Aged, Obesity/complications, Overweight/complications, Transportation, Young Adult",

author = "Gram, {Anne Sofie} and Else-Marie Bladbjerg and Quist, {Jonas Salling} and Petersen, {Martin B{\ae}k} and Mads Rosenkilde and Bente Stallknecht",

year = "2017",

month = oct,

doi = "10.1016/j.atherosclerosis.2017.06.923",

language = "English",

volume = "265",

pages = "318--324",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men

T2 - A randomized controlled trial

AU - Gram, Anne Sofie

AU - Bladbjerg, Else-Marie

AU - Quist, Jonas Salling

AU - Petersen, Martin Bæk

AU - Rosenkilde, Mads

AU - Stallknecht, Bente

PY - 2017/10

Y1 - 2017/10

N2 - BACKGROUND AND AIMS: Physical inactivity is linked to low-grade inflammation, endothelial dysfunction and cardiovascular disease. We aimed to determine effects of active commuting and leisure time exercise on markers of low-grade inflammation and endothelial function in overweight and obese women and men.METHODS: We randomized 130 younger (20-45 years), physically inactive, healthy, overweight and obese (BMI: 25-35 kg/m2) women and men recruited from the Copenhagen area, Denmark, to either 6 months of habitual lifestyle (CON, n = 18), active commuting (BIKE, n = 35), or leisure time exercise of moderate (MOD, ∼50% VO2peak, n = 39) or vigorous intensity (VIG, ∼70% VO2peak, n = 38). Fasting blood samples were collected at baseline, 3, and 6 months and analyzed for concentrations of C-reactive protein (CRP), fibrinogen, von Willebrand factor (vWF), tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor type 1 (PAI-1), and 90 participants (CON, n = 16; BIKE, n = 19; MOD, n = 31, VIG, n = 24) were included in a per-protocol analysis.RESULTS: We observed lower concentrations of CRP in MOD compared with CON at 6 months (p = 0.013) and within-group decreases in CRP in BIKE (3 months: p = 0.045) and MOD (3 months: p = 0.061; 6 months: p = 0.038) corresponding to a 30% decrease in BIKE and 19% in MOD from baseline till 6 months. No effects of exercise were observed on fibrinogen, vWF, t-PA, PAI-1 or the t-PA/PAI-1 ratio within or between groups.CONCLUSIONS: Our findings suggest an anti-inflammatory effect of active commuting and moderate, but not vigorous, intensity leisure time exercise, but no alterations in endothelial function during 6 months of intervention.

AB - BACKGROUND AND AIMS: Physical inactivity is linked to low-grade inflammation, endothelial dysfunction and cardiovascular disease. We aimed to determine effects of active commuting and leisure time exercise on markers of low-grade inflammation and endothelial function in overweight and obese women and men.METHODS: We randomized 130 younger (20-45 years), physically inactive, healthy, overweight and obese (BMI: 25-35 kg/m2) women and men recruited from the Copenhagen area, Denmark, to either 6 months of habitual lifestyle (CON, n = 18), active commuting (BIKE, n = 35), or leisure time exercise of moderate (MOD, ∼50% VO2peak, n = 39) or vigorous intensity (VIG, ∼70% VO2peak, n = 38). Fasting blood samples were collected at baseline, 3, and 6 months and analyzed for concentrations of C-reactive protein (CRP), fibrinogen, von Willebrand factor (vWF), tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor type 1 (PAI-1), and 90 participants (CON, n = 16; BIKE, n = 19; MOD, n = 31, VIG, n = 24) were included in a per-protocol analysis.RESULTS: We observed lower concentrations of CRP in MOD compared with CON at 6 months (p = 0.013) and within-group decreases in CRP in BIKE (3 months: p = 0.045) and MOD (3 months: p = 0.061; 6 months: p = 0.038) corresponding to a 30% decrease in BIKE and 19% in MOD from baseline till 6 months. No effects of exercise were observed on fibrinogen, vWF, t-PA, PAI-1 or the t-PA/PAI-1 ratio within or between groups.CONCLUSIONS: Our findings suggest an anti-inflammatory effect of active commuting and moderate, but not vigorous, intensity leisure time exercise, but no alterations in endothelial function during 6 months of intervention.

KW - Adult

KW - Exercise

KW - Female

KW - Humans

KW - Inflammation/etiology

KW - Leisure Activities

KW - Male

KW - Middle Aged

KW - Obesity/complications

KW - Overweight/complications

KW - Transportation

KW - Young Adult

U2 - 10.1016/j.atherosclerosis.2017.06.923

DO - 10.1016/j.atherosclerosis.2017.06.923

M3 - Journal article

C2 - 28679486

SN - 0021-9150

VL - 265

SP - 318

EP - 324

JO - Atherosclerosis

JF - Atherosclerosis

ER -

Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men: A randomized controlled trial

Abstract

Keywords

UN SDGs

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