Anhedonia and cognitive function in adults with MDD: results from the International Mood Disorders Collaborative Project

Roger S McIntyre; Hanna O Woldeyohannes; Joanna K Soczynska; Nadia A Maruschak; Ida K Wium-Andersen; Maj Vinberg; Danielle S Cha; Yena Lee; Holly X Xiao; Laura Ashley Gallaugher; Roman M Dale; Mohammad T Alsuwaidan; Rodrigo B Mansur; David J Muzina; Andre F Carvalho; Jeanette M Jerrell; Sidney H Kennedy

doi:10.1017/S1092852915000747

Anhedonia and cognitive function in adults with MDD: results from the International Mood Disorders Collaborative Project

Roger S McIntyre, Hanna O Woldeyohannes, Joanna K Soczynska, Nadia A Maruschak, Ida K Wium-Andersen, Maj Vinberg, Danielle S Cha, Yena Lee, Holly X Xiao, Laura Ashley Gallaugher, Roman M Dale, Mohammad T Alsuwaidan, Rodrigo B Mansur, David J Muzina, Andre F Carvalho, Jeanette M Jerrell, Sidney H Kennedy

Department of Clinical Medicine

14 Citations (Scopus)

Abstract

BACKGROUND: Cognitive dysfunction is common in major depressive disorder (MDD) and a critical determinant of health outcome. Anhedonia is a criterion item toward the diagnosis of a major depressive episode (MDE) and a well-characterized domain in MDD. We sought to determine the extent to which variability in self-reported cognitive function correlates with anhedonia.

METHOD: A post hoc analysis was conducted using data from (N=369) participants with a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR)-defined diagnosis of MDD who were enrolled in the International Mood Disorders Collaborative Project (IMDCP) between January 2008 and July 2013. The IMDCP is a collaborative research platform at the Mood Disorders Psychopharmacology Unit, University of Toronto, Toronto, Canada, and the Cleveland Clinic, Cleveland, Ohio. Measures of cognitive function, anhedonia, and depression severity were analyzed using linear regression equations.

RESULTS: A total of 369 adults with DSM-IV-TR-defined MDD were included in this analysis. Self-rated cognitive impairment [ie, as measured by the Adult ADHD Self-Report Scale (ASRS)] was significantly correlated with a proxy measure of anhedonia (r=0.131, p=0.012). Moreover, total depression symptom severity, as measured by the total Montgomery-Åsberg Depression Rating Scale (MADRS) score, was also significantly correlated with self-rated measures of cognitive dysfunction (r=0.147, p=0.005). The association between anhedonia and self-rated cognitive dysfunction remained significant after adjusting for illness severity (r=0.162, p=0.007).

CONCLUSIONS: These preliminary results provide empirical data for the testable hypothesis that anhedonia and self-reported cognitive function in MDD are correlated yet dissociable domains. The foregoing observation supports the hypothesis of overlapping yet discrete neurobiological substrates for these domains.

Original language	English
Journal	C N S Spectrums
Pages (from-to)	1-5
Number of pages	5
ISSN	1092-8529
DOIs	https://doi.org/10.1017/S1092852915000747
Publication status	Published - 1 Oct 2016

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McIntyre, R. S., Woldeyohannes, H. O., Soczynska, J. K., Maruschak, N. A., Wium-Andersen, I. K., Vinberg, M., Cha, D. S., Lee, Y., Xiao, H. X., Gallaugher, L. A., Dale, R. M., Alsuwaidan, M. T., Mansur, R. B., Muzina, D. J., Carvalho, A. F., Jerrell, J. M., & Kennedy, S. H. (2016). Anhedonia and cognitive function in adults with MDD: results from the International Mood Disorders Collaborative Project. C N S Spectrums, 1-5. https://doi.org/10.1017/S1092852915000747

McIntyre, RS, Woldeyohannes, HO, Soczynska, JK, Maruschak, NA, Wium-Andersen, IK, Vinberg, M, Cha, DS, Lee, Y, Xiao, HX, Gallaugher, LA, Dale, RM, Alsuwaidan, MT, Mansur, RB, Muzina, DJ, Carvalho, AF, Jerrell, JM & Kennedy, SH 2016, 'Anhedonia and cognitive function in adults with MDD: results from the International Mood Disorders Collaborative Project', C N S Spectrums, pp. 1-5. https://doi.org/10.1017/S1092852915000747

@article{c36a2deceb804802a024810cdf732ce7,

title = "Anhedonia and cognitive function in adults with MDD: results from the International Mood Disorders Collaborative Project",

abstract = "BACKGROUND: Cognitive dysfunction is common in major depressive disorder (MDD) and a critical determinant of health outcome. Anhedonia is a criterion item toward the diagnosis of a major depressive episode (MDE) and a well-characterized domain in MDD. We sought to determine the extent to which variability in self-reported cognitive function correlates with anhedonia.METHOD: A post hoc analysis was conducted using data from (N=369) participants with a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR)-defined diagnosis of MDD who were enrolled in the International Mood Disorders Collaborative Project (IMDCP) between January 2008 and July 2013. The IMDCP is a collaborative research platform at the Mood Disorders Psychopharmacology Unit, University of Toronto, Toronto, Canada, and the Cleveland Clinic, Cleveland, Ohio. Measures of cognitive function, anhedonia, and depression severity were analyzed using linear regression equations.RESULTS: A total of 369 adults with DSM-IV-TR-defined MDD were included in this analysis. Self-rated cognitive impairment [ie, as measured by the Adult ADHD Self-Report Scale (ASRS)] was significantly correlated with a proxy measure of anhedonia (r=0.131, p=0.012). Moreover, total depression symptom severity, as measured by the total Montgomery-{\AA}sberg Depression Rating Scale (MADRS) score, was also significantly correlated with self-rated measures of cognitive dysfunction (r=0.147, p=0.005). The association between anhedonia and self-rated cognitive dysfunction remained significant after adjusting for illness severity (r=0.162, p=0.007).CONCLUSIONS: These preliminary results provide empirical data for the testable hypothesis that anhedonia and self-reported cognitive function in MDD are correlated yet dissociable domains. The foregoing observation supports the hypothesis of overlapping yet discrete neurobiological substrates for these domains.",

author = "McIntyre, {Roger S} and Woldeyohannes, {Hanna O} and Soczynska, {Joanna K} and Maruschak, {Nadia A} and Wium-Andersen, {Ida K} and Maj Vinberg and Cha, {Danielle S} and Yena Lee and Xiao, {Holly X} and Gallaugher, {Laura Ashley} and Dale, {Roman M} and Alsuwaidan, {Mohammad T} and Mansur, {Rodrigo B} and Muzina, {David J} and Carvalho, {Andre F} and Jerrell, {Jeanette M} and Kennedy, {Sidney H}",

year = "2016",

month = oct,

day = "1",

doi = "10.1017/S1092852915000747",

language = "English",

pages = "1--5",

journal = "CNS Spectrums",

issn = "1092-8529",

publisher = "Cambridge University Press",

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TY - JOUR

T1 - Anhedonia and cognitive function in adults with MDD

T2 - results from the International Mood Disorders Collaborative Project

AU - McIntyre, Roger S

AU - Woldeyohannes, Hanna O

AU - Soczynska, Joanna K

AU - Maruschak, Nadia A

AU - Wium-Andersen, Ida K

AU - Vinberg, Maj

AU - Cha, Danielle S

AU - Lee, Yena

AU - Xiao, Holly X

AU - Gallaugher, Laura Ashley

AU - Dale, Roman M

AU - Alsuwaidan, Mohammad T

AU - Mansur, Rodrigo B

AU - Muzina, David J

AU - Carvalho, Andre F

AU - Jerrell, Jeanette M

AU - Kennedy, Sidney H

PY - 2016/10/1

Y1 - 2016/10/1

N2 - BACKGROUND: Cognitive dysfunction is common in major depressive disorder (MDD) and a critical determinant of health outcome. Anhedonia is a criterion item toward the diagnosis of a major depressive episode (MDE) and a well-characterized domain in MDD. We sought to determine the extent to which variability in self-reported cognitive function correlates with anhedonia.METHOD: A post hoc analysis was conducted using data from (N=369) participants with a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR)-defined diagnosis of MDD who were enrolled in the International Mood Disorders Collaborative Project (IMDCP) between January 2008 and July 2013. The IMDCP is a collaborative research platform at the Mood Disorders Psychopharmacology Unit, University of Toronto, Toronto, Canada, and the Cleveland Clinic, Cleveland, Ohio. Measures of cognitive function, anhedonia, and depression severity were analyzed using linear regression equations.RESULTS: A total of 369 adults with DSM-IV-TR-defined MDD were included in this analysis. Self-rated cognitive impairment [ie, as measured by the Adult ADHD Self-Report Scale (ASRS)] was significantly correlated with a proxy measure of anhedonia (r=0.131, p=0.012). Moreover, total depression symptom severity, as measured by the total Montgomery-Åsberg Depression Rating Scale (MADRS) score, was also significantly correlated with self-rated measures of cognitive dysfunction (r=0.147, p=0.005). The association between anhedonia and self-rated cognitive dysfunction remained significant after adjusting for illness severity (r=0.162, p=0.007).CONCLUSIONS: These preliminary results provide empirical data for the testable hypothesis that anhedonia and self-reported cognitive function in MDD are correlated yet dissociable domains. The foregoing observation supports the hypothesis of overlapping yet discrete neurobiological substrates for these domains.

AB - BACKGROUND: Cognitive dysfunction is common in major depressive disorder (MDD) and a critical determinant of health outcome. Anhedonia is a criterion item toward the diagnosis of a major depressive episode (MDE) and a well-characterized domain in MDD. We sought to determine the extent to which variability in self-reported cognitive function correlates with anhedonia.METHOD: A post hoc analysis was conducted using data from (N=369) participants with a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR)-defined diagnosis of MDD who were enrolled in the International Mood Disorders Collaborative Project (IMDCP) between January 2008 and July 2013. The IMDCP is a collaborative research platform at the Mood Disorders Psychopharmacology Unit, University of Toronto, Toronto, Canada, and the Cleveland Clinic, Cleveland, Ohio. Measures of cognitive function, anhedonia, and depression severity were analyzed using linear regression equations.RESULTS: A total of 369 adults with DSM-IV-TR-defined MDD were included in this analysis. Self-rated cognitive impairment [ie, as measured by the Adult ADHD Self-Report Scale (ASRS)] was significantly correlated with a proxy measure of anhedonia (r=0.131, p=0.012). Moreover, total depression symptom severity, as measured by the total Montgomery-Åsberg Depression Rating Scale (MADRS) score, was also significantly correlated with self-rated measures of cognitive dysfunction (r=0.147, p=0.005). The association between anhedonia and self-rated cognitive dysfunction remained significant after adjusting for illness severity (r=0.162, p=0.007).CONCLUSIONS: These preliminary results provide empirical data for the testable hypothesis that anhedonia and self-reported cognitive function in MDD are correlated yet dissociable domains. The foregoing observation supports the hypothesis of overlapping yet discrete neurobiological substrates for these domains.

U2 - 10.1017/S1092852915000747

DO - 10.1017/S1092852915000747

M3 - Journal article

C2 - 26714651

SN - 1092-8529

SP - 1

EP - 5

JO - CNS Spectrums

JF - CNS Spectrums

ER -

Anhedonia and cognitive function in adults with MDD: results from the International Mood Disorders Collaborative Project

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