Ancient human microbiomes

Christina Warinner, Camilla Speller, Matthew J. Collins, Cecil M. Lewis*

*Corresponding author for this work
    59 Citations (Scopus)

    Abstract

    Very recently, we discovered a vast new microbial self: the human microbiome. Our native microbiota interface with our biology and culture to influence our health, behavior, and quality of life, and yet we know very little about their origin, evolution, or ecology. With the advent of industrialization, globalization, and modern sanitation, it is intuitive that we have changed our relationship with microbes, but we have little information about the ancestral state of our microbiome, and we therefore lack a foundation for characterizing this change. High-throughput sequencing has opened up new opportunities in the field of paleomicrobiology, allowing us to investigate the evolution of the complex microbial ecologies that inhabit our bodies. By focusing on recent coprolite and dental calculus research, we explore how emerging research on ancient human microbiomes is changing the way we think about ancient disease and how archaeological studies can contribute to a medical understanding of health and nutrition today.

    Original languageEnglish
    JournalJournal of Human Evolution
    Volume79
    Pages (from-to)125-136
    Number of pages12
    ISSN0047-2484
    DOIs
    Publication statusPublished - 1 Feb 2015

    Keywords

    • Ancient DNA
    • Coprolite
    • Dental calculus
    • Feces
    • Metagenomics
    • Metaproteomics

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