Analysing the distribution of synaptic vesicles using a spatial point process model

TY - GEN

T1 - Analysing the distribution of synaptic vesicles using a spatial point process model

AU - Khanmohammadi, Mahdieh

AU - Waagepetersen, Rasmus

AU - Nava, Nicoletta

AU - Nyengaard, Jens

AU - Sporring, Jon

N1 - Conference code: 5

PY - 2014/9/20

Y1 - 2014/9/20

N2 - Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: a control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode.We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.

AB - Stress can affect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the effect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: a control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode.We hypothesize that the synaptic vesicles have different spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have different spatial distributions.

KW - Faculty of Health and Medical Sciences

KW - Synaptic vesicles distribution,

KW - Spatial point process

KW - Serial section transmission electron microscopy images,

KW - Stress

U2 - 10.1145/2649387.2649404

DO - 10.1145/2649387.2649404

M3 - Article in proceedings

SP - 73

EP - 78

BT - Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics

PB - Association for Computing Machinery

T2 - 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics

Y2 - 20 September 2014 through 23 September 2014

ER -