Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study

Lesli Hingstrup Larsen; Lars Henrik Ängquist; Karani S Vimaleswaran; Jörg Hager; Nathalie Viguerie; Ruth J F Loos; Teodora Handjieva-Darlenska; Susan A Jebb; Marie Kunesova; Thomas Meinert Larsen; J Alfredo Martinez; Angeliki Papadaki; Andreas F H Pfeiffer; Marleen A van Baak; Thorkild I.A. Sørensen; Claus Holst; Dominique Langin; Arne Astrup; Wiim H M Saris

doi:10.3945/ajcn.111.016543

Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study

Lesli Hingstrup Larsen, Lars Henrik Ängquist, Karani S Vimaleswaran, Jörg Hager, Nathalie Viguerie, Ruth J F Loos, Teodora Handjieva-Darlenska, Susan A Jebb, Marie Kunesova, Thomas Meinert Larsen, J Alfredo Martinez, Angeliki Papadaki, Andreas F H Pfeiffer, Marleen A van Baak, Thorkild I.A. Sørensen, Claus Holst, Dominique Langin, Arne Astrup, Wiim H M Saris

31 Citations (Scopus)

Abstract

Background: Differences in the interindividual response to dietary intervention could be modified by genetic variation in nutrient-sensitive genes. Objective: This study examined single nucleotide polymorphisms (SNPs) in presumed nutrient-sensitive candidate genes for obesity and obesity-related diseases for main and dietary interaction effects on weight, waist circumference, and fat mass regain over 6 mo. Design: In total, 742 participants who had lost ≥8% of their initial body weight were randomly assigned to follow 1 of 5 different ad libitum diets with different glycemic indexes and contents of dietary protein. The SNP main and SNP-diet interaction effects were analyzed by using linear regression models, corrected for multiple testing by using Bonferroni correction and evaluated by using quantile-quantile (Q-Q) plots. Results: After correction for multiple testing, none of the SNPs were significantly associated with weight, waist circumference, or fat mass regain. Q-Q plots showed that ALOX5AP rs4769873 showed a higher observed than predicted P value for the association with less waist circumference regain over 6 mo (23.1 cm/allele; 95% CI: 24.6, 21.6; P/Bonferroni-corrected P = 0.000039/0.076), independently of diet. Additional associations were identified by using Q-Q plots for SNPs in ALOX5AP, TNF, and KCNJ11 for main effects; in LPL and TUB for glycemic index interaction effects on waist circumference regain; in GHRL, CCK, MLXIPL, and LEPR on weight; in PPARC1A, PCK2, ALOX5AP, PYY, and ADRB3 on waist circumference; and in PPARD, FABP1, PLAUR, and LPIN1 on fat mass regain for dietary protein interaction. Conclusion: The observed effects of SNP-diet interactions on weight, waist, and fat mass regain suggest that genetic variation in nutrientsensitive genes can modify the response to diet. This trial was registered at clinicaltrials.gov as NCT00390637.

Original language	English
Journal	American Journal of Clinical Nutrition
Volume	95
Issue number	5
Pages (from-to)	1254-1260
Number of pages	7
ISSN	0002-9165
DOIs	https://doi.org/10.3945/ajcn.111.016543
Publication status	Published - 1 May 2012

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Larsen, L. H., Ängquist, L. H., Vimaleswaran, K. S., Hager, J., Viguerie, N., Loos, R. J. F., Handjieva-Darlenska, T., Jebb, S. A., Kunesova, M., Larsen, T. M., Martinez, J. A., Papadaki, A., Pfeiffer, A. F. H., van Baak, M. A., Sørensen, T. I. A., Holst, C., Langin, D., Astrup, A., & Saris, W. H. M. (2012). Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study. American Journal of Clinical Nutrition, 95(5), 1254-1260. https://doi.org/10.3945/ajcn.111.016543

Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention : the DIOGENES study. / Larsen, Lesli Hingstrup; Ängquist, Lars Henrik; Vimaleswaran, Karani S et al.

In: American Journal of Clinical Nutrition, Vol. 95, No. 5, 01.05.2012, p. 1254-1260.

Research output: Contribution to journal › Journal article › Research › peer-review

Larsen, LH, Ängquist, LH, Vimaleswaran, KS, Hager, J, Viguerie, N, Loos, RJF, Handjieva-Darlenska, T, Jebb, SA, Kunesova, M, Larsen, TM, Martinez, JA, Papadaki, A, Pfeiffer, AFH, van Baak, MA, Sørensen, TIA, Holst, C, Langin, D, Astrup, A & Saris, WHM 2012, 'Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study', American Journal of Clinical Nutrition, vol. 95, no. 5, pp. 1254-1260. https://doi.org/10.3945/ajcn.111.016543

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title = "Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study",

abstract = "Background: Differences in the interindividual response to dietary intervention could be modified by genetic variation in nutrient-sensitive genes. Objective: This study examined single nucleotide polymorphisms (SNPs) in presumed nutrient-sensitive candidate genes for obesity and obesity-related diseases for main and dietary interaction effects on weight, waist circumference, and fat mass regain over 6 mo. Design: In total, 742 participants who had lost ≥8% of their initial body weight were randomly assigned to follow 1 of 5 different ad libitum diets with different glycemic indexes and contents of dietary protein. The SNP main and SNP-diet interaction effects were analyzed by using linear regression models, corrected for multiple testing by using Bonferroni correction and evaluated by using quantile-quantile (Q-Q) plots. Results: After correction for multiple testing, none of the SNPs were significantly associated with weight, waist circumference, or fat mass regain. Q-Q plots showed that ALOX5AP rs4769873 showed a higher observed than predicted P value for the association with less waist circumference regain over 6 mo (23.1 cm/allele; 95% CI: 24.6, 21.6; P/Bonferroni-corrected P = 0.000039/0.076), independently of diet. Additional associations were identified by using Q-Q plots for SNPs in ALOX5AP, TNF, and KCNJ11 for main effects; in LPL and TUB for glycemic index interaction effects on waist circumference regain; in GHRL, CCK, MLXIPL, and LEPR on weight; in PPARC1A, PCK2, ALOX5AP, PYY, and ADRB3 on waist circumference; and in PPARD, FABP1, PLAUR, and LPIN1 on fat mass regain for dietary protein interaction. Conclusion: The observed effects of SNP-diet interactions on weight, waist, and fat mass regain suggest that genetic variation in nutrientsensitive genes can modify the response to diet. This trial was registered at clinicaltrials.gov as NCT00390637.",

author = "Larsen, {Lesli Hingstrup} and {\"A}ngquist, {Lars Henrik} and Vimaleswaran, {Karani S} and J{\"o}rg Hager and Nathalie Viguerie and Loos, {Ruth J F} and Teodora Handjieva-Darlenska and Jebb, {Susan A} and Marie Kunesova and Larsen, {Thomas Meinert} and Martinez, {J Alfredo} and Angeliki Papadaki and Pfeiffer, {Andreas F H} and {van Baak}, {Marleen A} and S{\o}rensen, {Thorkild I.A.} and Claus Holst and Dominique Langin and Arne Astrup and Saris, {Wiim H M}",

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journal = "American Journal of Clinical Nutrition",

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TY - JOUR

T1 - Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention

T2 - the DIOGENES study

AU - Larsen, Lesli Hingstrup

AU - Ängquist, Lars Henrik

AU - Vimaleswaran, Karani S

AU - Hager, Jörg

AU - Viguerie, Nathalie

AU - Loos, Ruth J F

AU - Handjieva-Darlenska, Teodora

AU - Jebb, Susan A

AU - Kunesova, Marie

AU - Larsen, Thomas Meinert

AU - Martinez, J Alfredo

AU - Papadaki, Angeliki

AU - Pfeiffer, Andreas F H

AU - van Baak, Marleen A

AU - Sørensen, Thorkild I.A.

AU - Holst, Claus

AU - Langin, Dominique

AU - Astrup, Arne

AU - Saris, Wiim H M

N1 - IHE 2012 003

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Background: Differences in the interindividual response to dietary intervention could be modified by genetic variation in nutrient-sensitive genes. Objective: This study examined single nucleotide polymorphisms (SNPs) in presumed nutrient-sensitive candidate genes for obesity and obesity-related diseases for main and dietary interaction effects on weight, waist circumference, and fat mass regain over 6 mo. Design: In total, 742 participants who had lost ≥8% of their initial body weight were randomly assigned to follow 1 of 5 different ad libitum diets with different glycemic indexes and contents of dietary protein. The SNP main and SNP-diet interaction effects were analyzed by using linear regression models, corrected for multiple testing by using Bonferroni correction and evaluated by using quantile-quantile (Q-Q) plots. Results: After correction for multiple testing, none of the SNPs were significantly associated with weight, waist circumference, or fat mass regain. Q-Q plots showed that ALOX5AP rs4769873 showed a higher observed than predicted P value for the association with less waist circumference regain over 6 mo (23.1 cm/allele; 95% CI: 24.6, 21.6; P/Bonferroni-corrected P = 0.000039/0.076), independently of diet. Additional associations were identified by using Q-Q plots for SNPs in ALOX5AP, TNF, and KCNJ11 for main effects; in LPL and TUB for glycemic index interaction effects on waist circumference regain; in GHRL, CCK, MLXIPL, and LEPR on weight; in PPARC1A, PCK2, ALOX5AP, PYY, and ADRB3 on waist circumference; and in PPARD, FABP1, PLAUR, and LPIN1 on fat mass regain for dietary protein interaction. Conclusion: The observed effects of SNP-diet interactions on weight, waist, and fat mass regain suggest that genetic variation in nutrientsensitive genes can modify the response to diet. This trial was registered at clinicaltrials.gov as NCT00390637.

AB - Background: Differences in the interindividual response to dietary intervention could be modified by genetic variation in nutrient-sensitive genes. Objective: This study examined single nucleotide polymorphisms (SNPs) in presumed nutrient-sensitive candidate genes for obesity and obesity-related diseases for main and dietary interaction effects on weight, waist circumference, and fat mass regain over 6 mo. Design: In total, 742 participants who had lost ≥8% of their initial body weight were randomly assigned to follow 1 of 5 different ad libitum diets with different glycemic indexes and contents of dietary protein. The SNP main and SNP-diet interaction effects were analyzed by using linear regression models, corrected for multiple testing by using Bonferroni correction and evaluated by using quantile-quantile (Q-Q) plots. Results: After correction for multiple testing, none of the SNPs were significantly associated with weight, waist circumference, or fat mass regain. Q-Q plots showed that ALOX5AP rs4769873 showed a higher observed than predicted P value for the association with less waist circumference regain over 6 mo (23.1 cm/allele; 95% CI: 24.6, 21.6; P/Bonferroni-corrected P = 0.000039/0.076), independently of diet. Additional associations were identified by using Q-Q plots for SNPs in ALOX5AP, TNF, and KCNJ11 for main effects; in LPL and TUB for glycemic index interaction effects on waist circumference regain; in GHRL, CCK, MLXIPL, and LEPR on weight; in PPARC1A, PCK2, ALOX5AP, PYY, and ADRB3 on waist circumference; and in PPARD, FABP1, PLAUR, and LPIN1 on fat mass regain for dietary protein interaction. Conclusion: The observed effects of SNP-diet interactions on weight, waist, and fat mass regain suggest that genetic variation in nutrientsensitive genes can modify the response to diet. This trial was registered at clinicaltrials.gov as NCT00390637.

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DO - 10.3945/ajcn.111.016543

M3 - Journal article

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EP - 1260

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

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ER -

Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study

Abstract

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