An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases.

K. Linnet; A. Steentoft; Kirsten Wiese Simonsen; Anne Sabers; Steen Holger Hansen

doi:10.1016/j.forsciint.2007.10.002

An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases.

K. Linnet, A. Steentoft, Kirsten Wiese Simonsen, Anne Sabers, Steen Holger Hansen

12 Citations (Scopus)

Abstract

We present an oxcarbazepine-related fatality together with an overview of 26 postmortem cases involving oxcarbazepine observed during the period 2001-2006. The fatality case concerned a 27-year-old woman with epilepsy, who was found dead in her bed. Oxcarbazepine and its active metabolite, 10-hydroxycarbazepine, were the only compounds detected. The concentrations of oxcarbazepine were as follows: femoral blood, 2.9 mg/kg; muscle, 1.8 mg/kg; liver, 0.9 mg/kg; gastric content (300 ml), 860 mg/kg; and vitreous humour, not detected. The concentrations of 10-hydroxycarbazepine were as follows: femoral blood, 66 mg/kg; muscle, 40 mg/kg; liver, 62 mg/kg; gastric content, 27 mg/kg; and vitreous humour, 25 mg/kg. The analyses were performed by HPLC-DAD after liquid-liquid extraction. Oxcarbazepine intoxication was regarded as a possible cause of death. For the other 26 cases, the 10-hydroxycarbazepine concentrations ranged from 2.2 to 48 mg/kg with a median of 25 mg/kg.

Original language	English
Journal	Forensic Science International
Volume	177
Issue number	2-3
Pages (from-to)	248-251
Number of pages	4
ISSN	0379-0738
DOIs	https://doi.org/10.1016/j.forsciint.2007.10.002
Publication status	Published - 2008

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title = "An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases.",

abstract = "We present an oxcarbazepine-related fatality together with an overview of 26 postmortem cases involving oxcarbazepine observed during the period 2001-2006. The fatality case concerned a 27-year-old woman with epilepsy, who was found dead in her bed. Oxcarbazepine and its active metabolite, 10-hydroxycarbazepine, were the only compounds detected. The concentrations of oxcarbazepine were as follows: femoral blood, 2.9 mg/kg; muscle, 1.8 mg/kg; liver, 0.9 mg/kg; gastric content (300 ml), 860 mg/kg; and vitreous humour, not detected. The concentrations of 10-hydroxycarbazepine were as follows: femoral blood, 66 mg/kg; muscle, 40 mg/kg; liver, 62 mg/kg; gastric content, 27 mg/kg; and vitreous humour, 25 mg/kg. The analyses were performed by HPLC-DAD after liquid-liquid extraction. Oxcarbazepine intoxication was regarded as a possible cause of death. For the other 26 cases, the 10-hydroxycarbazepine concentrations ranged from 2.2 to 48 mg/kg with a median of 25 mg/kg.",

author = "K. Linnet and A. Steentoft and Simonsen, {Kirsten Wiese} and Anne Sabers and Hansen, {Steen Holger}",

year = "2008",

doi = "10.1016/j.forsciint.2007.10.002",

language = "English",

volume = "177",

pages = "248--251",

journal = "Forensic Science International",

issn = "0379-0738",

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TY - JOUR

T1 - An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases.

AU - Linnet, K.

AU - Steentoft, A.

AU - Simonsen, Kirsten Wiese

AU - Sabers, Anne

AU - Hansen, Steen Holger

PY - 2008

Y1 - 2008

N2 - We present an oxcarbazepine-related fatality together with an overview of 26 postmortem cases involving oxcarbazepine observed during the period 2001-2006. The fatality case concerned a 27-year-old woman with epilepsy, who was found dead in her bed. Oxcarbazepine and its active metabolite, 10-hydroxycarbazepine, were the only compounds detected. The concentrations of oxcarbazepine were as follows: femoral blood, 2.9 mg/kg; muscle, 1.8 mg/kg; liver, 0.9 mg/kg; gastric content (300 ml), 860 mg/kg; and vitreous humour, not detected. The concentrations of 10-hydroxycarbazepine were as follows: femoral blood, 66 mg/kg; muscle, 40 mg/kg; liver, 62 mg/kg; gastric content, 27 mg/kg; and vitreous humour, 25 mg/kg. The analyses were performed by HPLC-DAD after liquid-liquid extraction. Oxcarbazepine intoxication was regarded as a possible cause of death. For the other 26 cases, the 10-hydroxycarbazepine concentrations ranged from 2.2 to 48 mg/kg with a median of 25 mg/kg.

AB - We present an oxcarbazepine-related fatality together with an overview of 26 postmortem cases involving oxcarbazepine observed during the period 2001-2006. The fatality case concerned a 27-year-old woman with epilepsy, who was found dead in her bed. Oxcarbazepine and its active metabolite, 10-hydroxycarbazepine, were the only compounds detected. The concentrations of oxcarbazepine were as follows: femoral blood, 2.9 mg/kg; muscle, 1.8 mg/kg; liver, 0.9 mg/kg; gastric content (300 ml), 860 mg/kg; and vitreous humour, not detected. The concentrations of 10-hydroxycarbazepine were as follows: femoral blood, 66 mg/kg; muscle, 40 mg/kg; liver, 62 mg/kg; gastric content, 27 mg/kg; and vitreous humour, 25 mg/kg. The analyses were performed by HPLC-DAD after liquid-liquid extraction. Oxcarbazepine intoxication was regarded as a possible cause of death. For the other 26 cases, the 10-hydroxycarbazepine concentrations ranged from 2.2 to 48 mg/kg with a median of 25 mg/kg.

U2 - 10.1016/j.forsciint.2007.10.002

DO - 10.1016/j.forsciint.2007.10.002

M3 - Journal article

C2 - 18036757

SN - 0379-0738

VL - 177

SP - 248

EP - 251

JO - Forensic Science International

JF - Forensic Science International

IS - 2-3

ER -

An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases.

Abstract

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