An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype typhimurium DT104

K. Molbak; Dorte Lau Baggesen; Frank Møller Aarestrup; J.M. Ebbesen; J. Engberg; K. Frydendahl; P. Gerner-Smidt; A.M. Petersen; Henrik Caspar Wegener

doi:10.1056/NEJM199911043411902

An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype typhimurium DT104

K. Molbak, Dorte Lau Baggesen, Frank Møller Aarestrup, J.M. Ebbesen, J. Engberg, K. Frydendahl, P. Gerner-Smidt, A.M. Petersen, Henrik Caspar Wegener

389 Citations (Scopus)

Abstract

Background Food-borne salmonella infections have become a major problem in industrialized countries. The strain of Salmonella enterica serotype typhimurium known as definitive phage type 104 (DT104) is usually resistant to five drugs: ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline. An increasing proportion of DT104 isolates also have reduced susceptibility to fluoroquinolones. Methods The Danish salmonella surveillance program determines the phage types of all typhimurium strains from the food chain, and in the case of suspected outbreaks, five-drug-resistant strains are characterized by molecular methods. All patients infected with five-drug-resistant typhimurium are interviewed to obtain clinical and epidemiologic data. In 1998, an outbreak of salmonella occurred, in which the strain of typhimurium DT104 was new to Denmark. We investigated this outbreak and report our findings here. Results Until 1997, DT104 infections made up less than 1 percent of all human salmonella infections. The strain isolated from patients in the first community outbreak of DT104 in Denmark, in 1998, was resistant to nalidixic acid and had reduced susceptibility to fluoroquinolones. The outbreak included 25 culture-confirmed cases. Eleven patients were hospitalized, and two died. The molecular epidemiology and data from patients indicated that the primary source was a Danish swine herd. Furthermore, the investigation suggested reduced clinical effectiveness of treatment with fluoroquinolones. Conclusions Our investigation of an outbreak of DT104 documented the spread of quinolone-resistant bacteria from food animals to humans; this spread was associated with infections that were difficult to treat. Because of the increase in quinolone resistance in salmonella, the use of fluoroquinolones in food animals should be restricted. (N Engl J Med 1999;341:1420-5.) (C)1999, Massachusetts Medical Society.

Original language	English
Journal	New England Journal of Medicine
Volume	341
Issue number	19
Pages (from-to)	1420-1425
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJM199911043411902
Publication status	Published - 1999
Externally published	Yes

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10.1056/NEJM199911043411902

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@article{0579ba6bb0e347479787963e2be8aff1,

title = "An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype typhimurium DT104",

abstract = "Background Food-borne salmonella infections have become a major problem in industrialized countries. The strain of Salmonella enterica serotype typhimurium known as definitive phage type 104 (DT104) is usually resistant to five drugs: ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline. An increasing proportion of DT104 isolates also have reduced susceptibility to fluoroquinolones. Methods The Danish salmonella surveillance program determines the phage types of all typhimurium strains from the food chain, and in the case of suspected outbreaks, five-drug-resistant strains are characterized by molecular methods. All patients infected with five-drug-resistant typhimurium are interviewed to obtain clinical and epidemiologic data. In 1998, an outbreak of salmonella occurred, in which the strain of typhimurium DT104 was new to Denmark. We investigated this outbreak and report our findings here. Results Until 1997, DT104 infections made up less than 1 percent of all human salmonella infections. The strain isolated from patients in the first community outbreak of DT104 in Denmark, in 1998, was resistant to nalidixic acid and had reduced susceptibility to fluoroquinolones. The outbreak included 25 culture-confirmed cases. Eleven patients were hospitalized, and two died. The molecular epidemiology and data from patients indicated that the primary source was a Danish swine herd. Furthermore, the investigation suggested reduced clinical effectiveness of treatment with fluoroquinolones. Conclusions Our investigation of an outbreak of DT104 documented the spread of quinolone-resistant bacteria from food animals to humans; this spread was associated with infections that were difficult to treat. Because of the increase in quinolone resistance in salmonella, the use of fluoroquinolones in food animals should be restricted. (N Engl J Med 1999;341:1420-5.) (C)1999, Massachusetts Medical Society.",

author = "K. Molbak and Baggesen, {Dorte Lau} and Aarestrup, {Frank M{\o}ller} and J.M. Ebbesen and J. Engberg and K. Frydendahl and P. Gerner-Smidt and A.M. Petersen and Wegener, {Henrik Caspar}",

year = "1999",

doi = "10.1056/NEJM199911043411902",

language = "English",

volume = "341",

pages = "1420--1425",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachusetts Medical Society",

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TY - JOUR

T1 - An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype typhimurium DT104

AU - Molbak, K.

AU - Baggesen, Dorte Lau

AU - Aarestrup, Frank Møller

AU - Ebbesen, J.M.

AU - Engberg, J.

AU - Frydendahl, K.

AU - Gerner-Smidt, P.

AU - Petersen, A.M.

AU - Wegener, Henrik Caspar

PY - 1999

Y1 - 1999

N2 - Background Food-borne salmonella infections have become a major problem in industrialized countries. The strain of Salmonella enterica serotype typhimurium known as definitive phage type 104 (DT104) is usually resistant to five drugs: ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline. An increasing proportion of DT104 isolates also have reduced susceptibility to fluoroquinolones. Methods The Danish salmonella surveillance program determines the phage types of all typhimurium strains from the food chain, and in the case of suspected outbreaks, five-drug-resistant strains are characterized by molecular methods. All patients infected with five-drug-resistant typhimurium are interviewed to obtain clinical and epidemiologic data. In 1998, an outbreak of salmonella occurred, in which the strain of typhimurium DT104 was new to Denmark. We investigated this outbreak and report our findings here. Results Until 1997, DT104 infections made up less than 1 percent of all human salmonella infections. The strain isolated from patients in the first community outbreak of DT104 in Denmark, in 1998, was resistant to nalidixic acid and had reduced susceptibility to fluoroquinolones. The outbreak included 25 culture-confirmed cases. Eleven patients were hospitalized, and two died. The molecular epidemiology and data from patients indicated that the primary source was a Danish swine herd. Furthermore, the investigation suggested reduced clinical effectiveness of treatment with fluoroquinolones. Conclusions Our investigation of an outbreak of DT104 documented the spread of quinolone-resistant bacteria from food animals to humans; this spread was associated with infections that were difficult to treat. Because of the increase in quinolone resistance in salmonella, the use of fluoroquinolones in food animals should be restricted. (N Engl J Med 1999;341:1420-5.) (C)1999, Massachusetts Medical Society.

AB - Background Food-borne salmonella infections have become a major problem in industrialized countries. The strain of Salmonella enterica serotype typhimurium known as definitive phage type 104 (DT104) is usually resistant to five drugs: ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline. An increasing proportion of DT104 isolates also have reduced susceptibility to fluoroquinolones. Methods The Danish salmonella surveillance program determines the phage types of all typhimurium strains from the food chain, and in the case of suspected outbreaks, five-drug-resistant strains are characterized by molecular methods. All patients infected with five-drug-resistant typhimurium are interviewed to obtain clinical and epidemiologic data. In 1998, an outbreak of salmonella occurred, in which the strain of typhimurium DT104 was new to Denmark. We investigated this outbreak and report our findings here. Results Until 1997, DT104 infections made up less than 1 percent of all human salmonella infections. The strain isolated from patients in the first community outbreak of DT104 in Denmark, in 1998, was resistant to nalidixic acid and had reduced susceptibility to fluoroquinolones. The outbreak included 25 culture-confirmed cases. Eleven patients were hospitalized, and two died. The molecular epidemiology and data from patients indicated that the primary source was a Danish swine herd. Furthermore, the investigation suggested reduced clinical effectiveness of treatment with fluoroquinolones. Conclusions Our investigation of an outbreak of DT104 documented the spread of quinolone-resistant bacteria from food animals to humans; this spread was associated with infections that were difficult to treat. Because of the increase in quinolone resistance in salmonella, the use of fluoroquinolones in food animals should be restricted. (N Engl J Med 1999;341:1420-5.) (C)1999, Massachusetts Medical Society.

U2 - 10.1056/NEJM199911043411902

DO - 10.1056/NEJM199911043411902

M3 - Journal article

SN - 0028-4793

VL - 341

SP - 1420

EP - 1425

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 19

ER -

An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype typhimurium DT104

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