TY - JOUR
T1 - An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis
T2 - A 24months follow-up
AU - Tnibar, Aziz
AU - Schougaard, Hans
AU - Camitz, Linus
AU - Rasmussen, Jonas
AU - Koene, Marc
AU - Jahn, Werner
AU - Markussen, Bo
PY - 2015/4/15
Y1 - 2015/4/15
N2 - Background: Polyacrylamide hydrogel (PAAG) was evaluated recently to treat osteoarthritis (OA) in horses with highly encouraging results; however no long term field-study was done to explore its clinical efficacy and lasting effect. The objective of this study was to evaluate the efficacy of PAAG in improving clinical signs of OA in horses. We hypothesized that lameness grade would significantly improve and the effect would last at least 2years in osteoarthritic joints treated with PAAG. Forty three horses older than 2years with OA in only one joint based on clinical evaluation, intra-articular anaesthesia and imaging (radiography) were included in this study. Horses were injected with 2ml of PAAG into the affected joint and were followed up at 1, 3, 6, 12 and 24months. Efficacy of PAAG was evaluated by blinded clinical assessment of lameness. Adverse reactions to joint injection were assessed. Data relating to case details, type of activity, joint and limb involved, lameness duration, lameness grading, previous joint treatment, joint effusion grading, radiographic grading, and owner assessment were recorded. Factors associated with the outcome measure "lameness grading" were analyzed using generalized linear mixed model for logistic regression. Results: At 1, 3, 6, 12 and 24months follow-up, 59%, 69%, 79%, 81/% and 82.5% of horses were non-lame respectively. Reduction of joint effusion was observed over time. No side effect was observed in the treated joints. There was a significant decrease in lameness grade from baseline to 1, 3, 6, 12 and 24months (P
AB - Background: Polyacrylamide hydrogel (PAAG) was evaluated recently to treat osteoarthritis (OA) in horses with highly encouraging results; however no long term field-study was done to explore its clinical efficacy and lasting effect. The objective of this study was to evaluate the efficacy of PAAG in improving clinical signs of OA in horses. We hypothesized that lameness grade would significantly improve and the effect would last at least 2years in osteoarthritic joints treated with PAAG. Forty three horses older than 2years with OA in only one joint based on clinical evaluation, intra-articular anaesthesia and imaging (radiography) were included in this study. Horses were injected with 2ml of PAAG into the affected joint and were followed up at 1, 3, 6, 12 and 24months. Efficacy of PAAG was evaluated by blinded clinical assessment of lameness. Adverse reactions to joint injection were assessed. Data relating to case details, type of activity, joint and limb involved, lameness duration, lameness grading, previous joint treatment, joint effusion grading, radiographic grading, and owner assessment were recorded. Factors associated with the outcome measure "lameness grading" were analyzed using generalized linear mixed model for logistic regression. Results: At 1, 3, 6, 12 and 24months follow-up, 59%, 69%, 79%, 81/% and 82.5% of horses were non-lame respectively. Reduction of joint effusion was observed over time. No side effect was observed in the treated joints. There was a significant decrease in lameness grade from baseline to 1, 3, 6, 12 and 24months (P
KW - 2years follow-up
KW - Horse
KW - Osteoarthritis
KW - Polyacrylamide hydrogel
KW - Treatment
U2 - 10.1186/s13028-015-0110-6
DO - 10.1186/s13028-015-0110-6
M3 - Journal article
C2 - 25887429
AN - SCOPUS:84939179935
SN - 0044-605X
VL - 57
JO - Acta Veterinaria Scandinavica (Online)
JF - Acta Veterinaria Scandinavica (Online)
IS - 1
M1 - 20
ER -