An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010"

TY - JOUR

T1 - An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010"

AU - Hartung, Thomas

AU - Blaauboer, Bas J

AU - Bosgra, Sieto

AU - Carney, Edward

AU - Coenen, Joachim

AU - Conolly, Rory B

AU - Corsini, Emanuela

AU - Green, Sidney

AU - Faustman, Elaine M

AU - Gaspari, Anthony

AU - Hayashi, Makoto

AU - Wallace Hayes, A

AU - Hengstler, Jan G

AU - Knudsen, Lisbeth E

AU - Knudsen, Thomas B

AU - McKim, James M

AU - Pfaller, Walter

AU - Roggen, Erwin L

PY - 2011

Y1 - 2011

N2 - The European cosmetics legislation foresees a review in 2011 and possible postponement of the 2013 marketing ban to enforce the testing ban for systemic and repeated-dose animal tests. For this purpose, a 119-page report commissioned by the European Commission was published recently. Here, a group of 17 independent experts from the US, Europe, and Japan was brought together to evaluate the report. The expert panel strongly endorsed the report and its conclusions. A number of important options not considered were identified; these do not, however, affect the overall conclusions regarding the current lack of availability of a full replacement, especially for the areas of repeated dose toxicity, carcinogenicity testing, and reproductive toxicity, though a roadmap for change is emerging. However, some of these options may provide adequate data for replacement of some animal studies in the near future pending validation. Various recommendations expand the original report. The reviewers agree with the report that there is greater promise in the short term for the areas of sensitization and toxicokinetics. Additional opportunities lie in more global collaborations and the inclusion of other industry sectors.

AB - The European cosmetics legislation foresees a review in 2011 and possible postponement of the 2013 marketing ban to enforce the testing ban for systemic and repeated-dose animal tests. For this purpose, a 119-page report commissioned by the European Commission was published recently. Here, a group of 17 independent experts from the US, Europe, and Japan was brought together to evaluate the report. The expert panel strongly endorsed the report and its conclusions. A number of important options not considered were identified; these do not, however, affect the overall conclusions regarding the current lack of availability of a full replacement, especially for the areas of repeated dose toxicity, carcinogenicity testing, and reproductive toxicity, though a roadmap for change is emerging. However, some of these options may provide adequate data for replacement of some animal studies in the near future pending validation. Various recommendations expand the original report. The reviewers agree with the report that there is greater promise in the short term for the areas of sensitization and toxicokinetics. Additional opportunities lie in more global collaborations and the inclusion of other industry sectors.

M3 - Journal article

C2 - 21993956

SN - 1868-596X

VL - 28

SP - 183

EP - 209

JO - A L T E X. Alternatives to Animal Experimentation

JF - A L T E X. Alternatives to Animal Experimentation

IS - 3

ER -