Abstract
Extracellular recordings are a key tool to record the activity of neurons in vivo. Especially in the case of experiments with behaving animals, however, the tedious procedure of electrode placement can take a considerable amount of expensive and restricted experimental time. Furthermore, due to tissue drifts and other sources of variability in the recording setup, the position of the electrodes with respect to the recorded neurons can change causing low recording quality. The contributions of this work are threefold. We introduce a quality measure for the recording position of the electrode which should be maximized during recordings and is especially suitable for the use of multi-electrodes. An automated positioning system based on this quality measure is proposed. The system is able to find favorable recording positions and adapts the electrode position smoothly to changes of the neuron positions. Finally, we evaluate the system using a new simulator for extracellular recordings based on realistically reconstructed 3D neurons.
| Original language | English |
|---|---|
| Journal | I E E E Engineering in Medicine and Biology Society. Conference Proceedings |
| Volume | 2010 |
| Pages (from-to) | 593-7 |
| Number of pages | 5 |
| ISSN | 2375-7477 |
| DOIs | |
| Publication status | Published - 2010 |
Keywords
- Action Potentials
- Animals
- Cats
- Computer Simulation
- Electrodes, Implanted
- Electrodiagnosis
- Models, Neurological
- Online Systems
- Prosthesis Implantation
- Pyramidal Cells
- Robotics