An antagonist of lipid A action in mammals has complex effects on lipid A induction of defence responses in the model plant Arabidopsis thaliana

Gitte Erbs; Tina Tandrup Jensen; Alba Silipo; William Grant; J. Maxwell Dow; Antonio Molinaro; Michelangelo Parrilli; Mari-Anne Newman

doi:10.1016/j.micinf.2008.01.008

An antagonist of lipid A action in mammals has complex effects on lipid A induction of defence responses in the model plant Arabidopsis thaliana

Gitte Erbs, Tina Tandrup Jensen, Alba Silipo, William Grant, J. Maxwell Dow, Antonio Molinaro, Michelangelo Parrilli, Mari-Anne Newman

7 Citations (Scopus)

Abstract

Lipopolysaccharides, the ubiquitous part of the outer membrane of Gram-negative bacteria, and their derivatives are recognised by plants to trigger or potentiate particular defence responses such as induction of genes encoding pathogenesis-related proteins. The molecular mechanisms of LPS perception that underpin these effects in plants are, however, unknown. Here, lipid A from Halomonas magadiensis, which is an antagonist of lipid A action in human cells, was used to investigate lipid A action in plants. Our findings offer an insight into the different structural requirements for direct induction and potentiation of plant defences by lipid A.

Original language	English
Journal	Microbes and Infection
Volume	10
Issue number	5
Pages (from-to)	571-574
Number of pages	4
ISSN	1286-4579
DOIs	https://doi.org/10.1016/j.micinf.2008.01.008
Publication status	Published - 2008

Keywords

Former LIFE faculty
PAMPs
Halomonas magadiensis
Lipid A
Antagonist
Arabidopsis thaliana

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10.1016/j.micinf.2008.01.008

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title = "An antagonist of lipid A action in mammals has complex effects on lipid A induction of defence responses in the model plant Arabidopsis thaliana",

abstract = "Lipopolysaccharides, the ubiquitous part of the outer membrane of Gram-negative bacteria, and their derivatives are recognised by plants to trigger or potentiate particular defence responses such as induction of genes encoding pathogenesis-related proteins. The molecular mechanisms of LPS perception that underpin these effects in plants are, however, unknown. Here, lipid A from Halomonas magadiensis, which is an antagonist of lipid A action in human cells, was used to investigate lipid A action in plants. Our findings offer an insight into the different structural requirements for direct induction and potentiation of plant defences by lipid A.",

keywords = "Former LIFE faculty, PAMPs, Halomonas magadiensis, Lipid A, Antagonist, Arabidopsis thaliana",

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T1 - An antagonist of lipid A action in mammals has complex effects on lipid A induction of defence responses in the model plant Arabidopsis thaliana

AU - Erbs, Gitte

AU - Jensen, Tina Tandrup

AU - Silipo, Alba

AU - Grant, William

AU - Dow, J. Maxwell

AU - Molinaro, Antonio

AU - Parrilli, Michelangelo

AU - Newman, Mari-Anne

PY - 2008

Y1 - 2008

N2 - Lipopolysaccharides, the ubiquitous part of the outer membrane of Gram-negative bacteria, and their derivatives are recognised by plants to trigger or potentiate particular defence responses such as induction of genes encoding pathogenesis-related proteins. The molecular mechanisms of LPS perception that underpin these effects in plants are, however, unknown. Here, lipid A from Halomonas magadiensis, which is an antagonist of lipid A action in human cells, was used to investigate lipid A action in plants. Our findings offer an insight into the different structural requirements for direct induction and potentiation of plant defences by lipid A.

AB - Lipopolysaccharides, the ubiquitous part of the outer membrane of Gram-negative bacteria, and their derivatives are recognised by plants to trigger or potentiate particular defence responses such as induction of genes encoding pathogenesis-related proteins. The molecular mechanisms of LPS perception that underpin these effects in plants are, however, unknown. Here, lipid A from Halomonas magadiensis, which is an antagonist of lipid A action in human cells, was used to investigate lipid A action in plants. Our findings offer an insight into the different structural requirements for direct induction and potentiation of plant defences by lipid A.

KW - Former LIFE faculty

KW - PAMPs

KW - Halomonas magadiensis

KW - Lipid A

KW - Antagonist

KW - Arabidopsis thaliana

U2 - 10.1016/j.micinf.2008.01.008

DO - 10.1016/j.micinf.2008.01.008

M3 - Journal article

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SN - 1286-4579

VL - 10

SP - 571

EP - 574

JO - Microbes and Infection

JF - Microbes and Infection

IS - 5

ER -

An antagonist of lipid A action in mammals has complex effects on lipid A induction of defence responses in the model plant Arabidopsis thaliana

Abstract

Keywords

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