An Aboriginal Australian genome reveals separate human dispersals into Asia

Morten Rasmussen; Xiaosen Guo; Yong Wang; Kirk E. Lohmueller; Simon Rasmussen; Anders Albrechtsen; Line Skotte; Stinus Lindgreen; Mait Metspalu; Thibaut Jombart; Toomas Kivisild; Weiwei Zhai; Anders Eriksson; Andrea Manica; Ludovic Orlando; Francisco M. De La Vega; Silvana Tridico; Ene Metspalu; Kasper Nielsen; Maria del Carmen Avila Arcos; José Victor Moreno Mayar; Craig Muller; Joe Dortch; Tom Gilbert; Ole Lund; Agata Wesolowska; Monika Karmin; Lucy A. Weinert; Bo Wang; Jun Li; Shuaishuai Tai; Fei Xiao; Tsunehiko Hanihara; George van Driem; Aashish R. Jha; François-Xavier Ricaut; Peter de Knijff; Andrea B. Migliano; Irene Gallego Romero; Karsten Kristiansen; David M. Lambert; Søren Brunak; Peter Forster; Bernd Brinkmann; Olaf Nehlich; Michael Bunce; Michael Richards; Ramneek Gupta; Carlos D. Bustamante; Anders Krogh; Robert A. Foley; Marta M. Lahr; Francois Balloux; Thomas Sicheritz-Pontén; Richard Villems; Rasmus Nielsen; Jun Wang; Eske Willerslev

doi:10.1126/science.1211177

An Aboriginal Australian genome reveals separate human dispersals into Asia

Morten Rasmussen, Xiaosen Guo, Yong Wang, Kirk E. Lohmueller, Simon Rasmussen, Anders Albrechtsen, Line Skotte, Stinus Lindgreen, Mait Metspalu, Thibaut Jombart, Toomas Kivisild, Weiwei Zhai, Anders Eriksson, Andrea Manica, Ludovic Orlando, Francisco M. De La Vega, Silvana Tridico, Ene Metspalu, Kasper Nielsen, Maria del Carmen Avila ArcosJosé Victor Moreno Mayar, Craig Muller, Joe Dortch, Tom Gilbert, Ole Lund, Agata Wesolowska, Monika Karmin, Lucy A. Weinert, Bo Wang, Jun Li, Shuaishuai Tai, Fei Xiao, Tsunehiko Hanihara, George van Driem, Aashish R. Jha, François-Xavier Ricaut, Peter de Knijff, Andrea B. Migliano, Irene Gallego Romero, Karsten Kristiansen, David M. Lambert, Søren Brunak, Peter Forster, Bernd Brinkmann, Olaf Nehlich, Michael Bunce, Michael Richards, Ramneek Gupta, Carlos D. Bustamante, Anders Krogh, Robert A. Foley, Marta M. Lahr, Francois Balloux, Thomas Sicheritz-Pontén, Richard Villems, Rasmus Nielsen, Jun Wang, Eske Willerslev

412 Citations (Scopus)

Abstract

We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago. This dispersal is separate from the one that gave rise to modern Asians 25,000 to 38,000 years ago. We also find evidence of gene flow between populations of the two dispersal waves prior to the divergence of Native Americans from modern Asian ancestors. Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa.

Original language	English
Journal	Science
Volume	334
Issue number	6052
Pages (from-to)	94-98
Number of pages	5
ISSN	0036-8075
DOIs	https://doi.org/10.1126/science.1211177
Publication status	Published - 7 Oct 2011

Keywords

African Continental Ancestry Group
Animals
Asia
Asian Continental Ancestry Group
Computer Simulation
DNA, Mitochondrial
Emigration and Immigration
Ethnic Groups
European Continental Ancestry Group
Far East
Gene Flow
Gene Frequency
Genetics, Population
Genome, Human
Genome, Mitochondrial
Haplotypes
Hominidae
Humans
Linkage Disequilibrium
Male
Oceanic Ancestry Group
Phylogeny
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Western Australia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Rasmussen, M., Guo, X., Wang, Y., Lohmueller, K. E., Rasmussen, S., Albrechtsen, A., Skotte, L., Lindgreen, S., Metspalu, M., Jombart, T., Kivisild, T., Zhai, W., Eriksson, A., Manica, A., Orlando, L., De La Vega, F. M., Tridico, S., Metspalu, E., Nielsen, K., ... Willerslev, E. (2011). An Aboriginal Australian genome reveals separate human dispersals into Asia. Science, 334(6052), 94-98. https://doi.org/10.1126/science.1211177

Rasmussen, M, Guo, X, Wang, Y, Lohmueller, KE, Rasmussen, S , Albrechtsen, A, Skotte, L, Lindgreen, S, Metspalu, M, Jombart, T, Kivisild, T, Zhai, W, Eriksson, A, Manica, A, Orlando, L, De La Vega, FM, Tridico, S, Metspalu, E, Nielsen, K, Avila Arcos, MDC, Moreno Mayar, JV, Muller, C, Dortch, J, Gilbert, T, Lund, O, Wesolowska, A, Karmin, M, Weinert, LA, Wang, B, Li, J, Tai, S, Xiao, F, Hanihara, T, van Driem, G, Jha, AR, Ricaut, F-X, de Knijff, P, Migliano, AB, Gallego Romero, I, Kristiansen, K, Lambert, DM, Brunak, S, Forster, P, Brinkmann, B, Nehlich, O, Bunce, M, Richards, M, Gupta, R, Bustamante, CD, Krogh, A, Foley, RA, Lahr, MM, Balloux, F, Sicheritz-Pontén, T, Villems, R, Nielsen, R, Wang, J & Willerslev, E 2011, 'An Aboriginal Australian genome reveals separate human dispersals into Asia', Science, vol. 334, no. 6052, pp. 94-98. https://doi.org/10.1126/science.1211177

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title = "An Aboriginal Australian genome reveals separate human dispersals into Asia",

abstract = "We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago. This dispersal is separate from the one that gave rise to modern Asians 25,000 to 38,000 years ago. We also find evidence of gene flow between populations of the two dispersal waves prior to the divergence of Native Americans from modern Asian ancestors. Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa.",

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author = "Morten Rasmussen and Xiaosen Guo and Yong Wang and Lohmueller, {Kirk E.} and Simon Rasmussen and Anders Albrechtsen and Line Skotte and Stinus Lindgreen and Mait Metspalu and Thibaut Jombart and Toomas Kivisild and Weiwei Zhai and Anders Eriksson and Andrea Manica and Ludovic Orlando and {De La Vega}, {Francisco M.} and Silvana Tridico and Ene Metspalu and Kasper Nielsen and {Avila Arcos}, {Maria del Carmen} and {Moreno Mayar}, {Jos{\'e} Victor} and Craig Muller and Joe Dortch and Tom Gilbert and Ole Lund and Agata Wesolowska and Monika Karmin and Weinert, {Lucy A.} and Bo Wang and Jun Li and Shuaishuai Tai and Fei Xiao and Tsunehiko Hanihara and {van Driem}, George and Jha, {Aashish R.} and Fran{\c c}ois-Xavier Ricaut and {de Knijff}, Peter and Migliano, {Andrea B.} and {Gallego Romero}, Irene and Karsten Kristiansen and Lambert, {David M.} and S{\o}ren Brunak and Peter Forster and Bernd Brinkmann and Olaf Nehlich and Michael Bunce and Michael Richards and Ramneek Gupta and Bustamante, {Carlos D.} and Anders Krogh and Foley, {Robert A.} and Lahr, {Marta M.} and Francois Balloux and Thomas Sicheritz-Pont{\'e}n and Richard Villems and Rasmus Nielsen and Jun Wang and Eske Willerslev",

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doi = "10.1126/science.1211177",

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volume = "334",

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journal = "Science",

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AU - Rasmussen, Morten

AU - Guo, Xiaosen

AU - Wang, Yong

AU - Lohmueller, Kirk E.

AU - Rasmussen, Simon

AU - Albrechtsen, Anders

AU - Skotte, Line

AU - Lindgreen, Stinus

AU - Metspalu, Mait

AU - Jombart, Thibaut

AU - Kivisild, Toomas

AU - Zhai, Weiwei

AU - Eriksson, Anders

AU - Manica, Andrea

AU - Orlando, Ludovic

AU - De La Vega, Francisco M.

AU - Tridico, Silvana

AU - Metspalu, Ene

AU - Nielsen, Kasper

AU - Avila Arcos, Maria del Carmen

AU - Moreno Mayar, José Victor

AU - Muller, Craig

AU - Dortch, Joe

AU - Gilbert, Tom

AU - Lund, Ole

AU - Wesolowska, Agata

AU - Karmin, Monika

AU - Weinert, Lucy A.

AU - Wang, Bo

AU - Li, Jun

AU - Tai, Shuaishuai

AU - Xiao, Fei

AU - Hanihara, Tsunehiko

AU - van Driem, George

AU - Jha, Aashish R.

AU - Ricaut, François-Xavier

AU - de Knijff, Peter

AU - Migliano, Andrea B.

AU - Gallego Romero, Irene

AU - Kristiansen, Karsten

AU - Lambert, David M.

AU - Brunak, Søren

AU - Forster, Peter

AU - Brinkmann, Bernd

AU - Nehlich, Olaf

AU - Bunce, Michael

AU - Richards, Michael

AU - Gupta, Ramneek

AU - Bustamante, Carlos D.

AU - Krogh, Anders

AU - Foley, Robert A.

AU - Lahr, Marta M.

AU - Balloux, Francois

AU - Sicheritz-Pontén, Thomas

AU - Villems, Richard

AU - Nielsen, Rasmus

AU - Wang, Jun

AU - Willerslev, Eske

PY - 2011/10/7

Y1 - 2011/10/7

N2 - We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago. This dispersal is separate from the one that gave rise to modern Asians 25,000 to 38,000 years ago. We also find evidence of gene flow between populations of the two dispersal waves prior to the divergence of Native Americans from modern Asian ancestors. Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa.

AB - We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago. This dispersal is separate from the one that gave rise to modern Asians 25,000 to 38,000 years ago. We also find evidence of gene flow between populations of the two dispersal waves prior to the divergence of Native Americans from modern Asian ancestors. Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa.

KW - African Continental Ancestry Group

KW - Animals

KW - Asia

KW - Asian Continental Ancestry Group

KW - Computer Simulation

KW - DNA, Mitochondrial

KW - Emigration and Immigration

KW - Ethnic Groups

KW - European Continental Ancestry Group

KW - Far East

KW - Gene Flow

KW - Gene Frequency

KW - Genetics, Population

KW - Genome, Human

KW - Genome, Mitochondrial

KW - Haplotypes

KW - Hominidae

KW - Humans

KW - Linkage Disequilibrium

KW - Male

KW - Oceanic Ancestry Group

KW - Phylogeny

KW - Polymorphism, Single Nucleotide

KW - Sequence Analysis, DNA

KW - Western Australia

U2 - 10.1126/science.1211177

DO - 10.1126/science.1211177

M3 - Journal article

C2 - 21940856

SN - 0036-8075

VL - 334

SP - 94

EP - 98

JO - Science

JF - Science

IS - 6052

ER -

An Aboriginal Australian genome reveals separate human dispersals into Asia

Abstract

Keywords

UN SDGs

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