Ambient air pollution and low birthweight: a European cohort study (ESCAPE)

Marie Pedersen; Lise Giorgis-Allemand; Claire Bernard; Inmaculada Aguilera; Anne-Marie Nybo Andersen; Ferran Ballester; Rob M J Beelen; Leda Chatzi; Marta Cirach; Asta Danileviciute; Audrius Dedele; Manon van Eijsden; Marisa Estarlich; Ana Fernández-Somoano; Mariana F Fernández; Francesco Forastiere; Ulrike Gehring; Regina Grazuleviciene; Olena Gruzieva; Barbara Heude; Gerard Hoek; Kees de Hoogh; Edith H van den Hooven; Siri E Håberg; Vincent W V Jaddoe; Claudia Klümper; Michal Korek; Ursula Krämer; Aitana Lerchundi; Johanna Lepeule; Per Nafstad; Wenche Nystad; Evridiki Patelarou; Daniela Porta; Dirkje Postma; Ole Raaschou-Nielsen; Peter Rudnai; Jordi Sunyer; Euripides Stephanou; Mette Sørensen; Elisabeth Thiering; Derek Tuffnell; Mihály J Varró; Tanja G M Vrijkotte; Alet Wijga; Michael Wilhelm; John Wright; Mark J Nieuwenhuijsen; Göran Pershagen; Bert Brunekreef; Manolis Kogevinas; Rémy Slama

doi:10.1016/s2213-2600(13)70192-9

Ambient air pollution and low birthweight: a European cohort study (ESCAPE)

Marie Pedersen, Lise Giorgis-Allemand, Claire Bernard, Inmaculada Aguilera, Anne-Marie Nybo Andersen, Ferran Ballester, Rob M J Beelen, Leda Chatzi, Marta Cirach, Asta Danileviciute, Audrius Dedele, Manon van Eijsden, Marisa Estarlich, Ana Fernández-Somoano, Mariana F Fernández, Francesco Forastiere, Ulrike Gehring, Regina Grazuleviciene, Olena Gruzieva, Barbara HeudeGerard Hoek, Kees de Hoogh, Edith H van den Hooven, Siri E Håberg, Vincent W V Jaddoe, Claudia Klümper, Michal Korek, Ursula Krämer, Aitana Lerchundi, Johanna Lepeule, Per Nafstad, Wenche Nystad, Evridiki Patelarou, Daniela Porta, Dirkje Postma, Ole Raaschou-Nielsen, Peter Rudnai, Jordi Sunyer, Euripides Stephanou, Mette Sørensen, Elisabeth Thiering, Derek Tuffnell, Mihály J Varró, Tanja G M Vrijkotte, Alet Wijga, Michael Wilhelm, John Wright, Mark J Nieuwenhuijsen, Göran Pershagen, Bert Brunekreef, Manolis Kogevinas, Rémy Slama

345 Citations (Scopus)

Abstract

Background: Ambient air pollution has been associated with restricted fetal growth, which is linked with adverse respiratory health in childhood. We assessed the effect of maternal exposure to low concentrations of ambient air pollution on birthweight. Methods: We pooled data from 14 population-based mother-child cohort studies in 12 European countries. Overall, the study population included 74178 women who had singleton deliveries between Feb 11, 1994, and June 2, 2011, and for whom information about infant birthweight, gestational age, and sex was available. The primary outcome of interest was low birthweight at term (weight <2500 g at birth after 37 weeks of gestation). Mean concentrations of particulate matter with an aerodynamic diameter of less than 25 μm (PM₂₅), less than 10 μm (PM₁₀), and between 25 μm and 10 μm during pregnancy were estimated at maternal home addresses with temporally adjusted land-use regression models, as was PM₂₅ absorbance and concentrations of nitrogen dioxide (NO₂) and nitrogen oxides. We also investigated traffic density on the nearest road and total traffic load. We calculated pooled effect estimates with random-effects models. Findings: A 5 μg/m³ increase in concentration of PM₂₅ during pregnancy was associated with an increased risk of low birthweight at term (adjusted odds ratio [OR] 118, 95% CI 106-133). An increased risk was also recorded for pregnancy concentrations lower than the present European Union annual PM₂₅ limit of 25 μg/m³ (OR for 5 μg/m³ increase in participants exposed to concentrations of less than 20 μg/m³ 141, 95% CI 120-165). PM₁₀ (OR for 10 μg/m³ increase 116, 95% CI 100-135), NO₂ (OR for 10 μg/m³ increase 109, 100-119), and traffic density on nearest street (OR for increase of 5000 vehicles per day 106, 101-111) were also associated with increased risk of low birthweight at term. The population attributable risk estimated for a reduction in PM₂₅ concentration to 10 μg/m³ during pregnancy corresponded to a decrease of 22% (95% CI 8-33%) in cases of low birthweight at term. Interpretation: Exposure to ambient air pollutants and traffic during pregnancy is associated with restricted fetal growth. A substantial proportion of cases of low birthweight at term could be prevented in Europe if urban air pollution was reduced. Funding: The European Union.

Original language	English
Journal	The lancet. Respiratory medicine
Volume	1
Issue number	9
Pages (from-to)	695-704
Number of pages	10
ISSN	2213-2600
DOIs	https://doi.org/10.1016/s2213-2600(13)70192-9
Publication status	Published - Nov 2013

Keywords

Adult
Air Pollution
Birth Weight
Environmental Exposure
Environmental Illness
Environmental Monitoring
Europe
Female
Humans
Incidence
Infant, Low Birth Weight
Infant, Newborn
Male
Maternal Exposure
Particulate Matter
Pregnancy
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/s2213-2600(13)70192-9

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Pedersen, M., Giorgis-Allemand, L., Bernard, C., Aguilera, I., Andersen, A-M. N., Ballester, F., Beelen, R. M. J., Chatzi, L., Cirach, M., Danileviciute, A., Dedele, A., Eijsden, M. V., Estarlich, M., Fernández-Somoano, A., Fernández, M. F., Forastiere, F., Gehring, U., Grazuleviciene, R., Gruzieva, O., ... Slama, R. (2013). Ambient air pollution and low birthweight: a European cohort study (ESCAPE). The lancet. Respiratory medicine, 1(9), 695-704. https://doi.org/10.1016/s2213-2600(13)70192-9

Pedersen, M, Giorgis-Allemand, L, Bernard, C, Aguilera, I, Andersen, A-MN, Ballester, F, Beelen, RMJ, Chatzi, L, Cirach, M, Danileviciute, A, Dedele, A, Eijsden, MV, Estarlich, M, Fernández-Somoano, A, Fernández, MF, Forastiere, F, Gehring, U, Grazuleviciene, R, Gruzieva, O, Heude, B, Hoek, G, de Hoogh, K, van den Hooven, EH, Håberg, SE, Jaddoe, VWV, Klümper, C, Korek, M, Krämer, U, Lerchundi, A, Lepeule, J, Nafstad, P, Nystad, W, Patelarou, E, Porta, D, Postma, D, Raaschou-Nielsen, O, Rudnai, P, Sunyer, J, Stephanou, E, Sørensen, M, Thiering, E, Tuffnell, D, Varró, MJ, Vrijkotte, TGM, Wijga, A, Wilhelm, M, Wright, J, Nieuwenhuijsen, MJ, Pershagen, G, Brunekreef, B, Kogevinas, M & Slama, R 2013, 'Ambient air pollution and low birthweight: a European cohort study (ESCAPE)', The lancet. Respiratory medicine, vol. 1, no. 9, pp. 695-704. https://doi.org/10.1016/s2213-2600(13)70192-9

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title = "Ambient air pollution and low birthweight: a European cohort study (ESCAPE)",

abstract = "Background: Ambient air pollution has been associated with restricted fetal growth, which is linked with adverse respiratory health in childhood. We assessed the effect of maternal exposure to low concentrations of ambient air pollution on birthweight. Methods: We pooled data from 14 population-based mother-child cohort studies in 12 European countries. Overall, the study population included 74178 women who had singleton deliveries between Feb 11, 1994, and June 2, 2011, and for whom information about infant birthweight, gestational age, and sex was available. The primary outcome of interest was low birthweight at term (weight <2500 g at birth after 37 weeks of gestation). Mean concentrations of particulate matter with an aerodynamic diameter of less than 25 μm (PM25), less than 10 μm (PM10), and between 25 μm and 10 μm during pregnancy were estimated at maternal home addresses with temporally adjusted land-use regression models, as was PM25 absorbance and concentrations of nitrogen dioxide (NO2) and nitrogen oxides. We also investigated traffic density on the nearest road and total traffic load. We calculated pooled effect estimates with random-effects models. Findings: A 5 μg/m3 increase in concentration of PM25 during pregnancy was associated with an increased risk of low birthweight at term (adjusted odds ratio [OR] 118, 95% CI 106-133). An increased risk was also recorded for pregnancy concentrations lower than the present European Union annual PM25 limit of 25 μg/m3 (OR for 5 μg/m3 increase in participants exposed to concentrations of less than 20 μg/m3 141, 95% CI 120-165). PM10 (OR for 10 μg/m3 increase 116, 95% CI 100-135), NO2 (OR for 10 μg/m3 increase 109, 100-119), and traffic density on nearest street (OR for increase of 5000 vehicles per day 106, 101-111) were also associated with increased risk of low birthweight at term. The population attributable risk estimated for a reduction in PM25 concentration to 10 μg/m3 during pregnancy corresponded to a decrease of 22% (95% CI 8-33%) in cases of low birthweight at term. Interpretation: Exposure to ambient air pollutants and traffic during pregnancy is associated with restricted fetal growth. A substantial proportion of cases of low birthweight at term could be prevented in Europe if urban air pollution was reduced. Funding: The European Union.",

keywords = "Adult, Air Pollution, Birth Weight, Environmental Exposure, Environmental Illness, Environmental Monitoring, Europe, Female, Humans, Incidence, Infant, Low Birth Weight, Infant, Newborn, Male, Maternal Exposure, Particulate Matter, Pregnancy, Young Adult",

author = "Marie Pedersen and Lise Giorgis-Allemand and Claire Bernard and Inmaculada Aguilera and Andersen, {Anne-Marie Nybo} and Ferran Ballester and Beelen, {Rob M J} and Leda Chatzi and Marta Cirach and Asta Danileviciute and Audrius Dedele and Eijsden, {Manon van} and Marisa Estarlich and Ana Fern{\'a}ndez-Somoano and Fern{\'a}ndez, {Mariana F} and Francesco Forastiere and Ulrike Gehring and Regina Grazuleviciene and Olena Gruzieva and Barbara Heude and Gerard Hoek and {de Hoogh}, Kees and {van den Hooven}, {Edith H} and H{\aa}berg, {Siri E} and Jaddoe, {Vincent W V} and Claudia Kl{\"u}mper and Michal Korek and Ursula Kr{\"a}mer and Aitana Lerchundi and Johanna Lepeule and Per Nafstad and Wenche Nystad and Evridiki Patelarou and Daniela Porta and Dirkje Postma and Ole Raaschou-Nielsen and Peter Rudnai and Jordi Sunyer and Euripides Stephanou and Mette S{\o}rensen and Elisabeth Thiering and Derek Tuffnell and Varr{\'o}, {Mih{\'a}ly J} and Vrijkotte, {Tanja G M} and Alet Wijga and Michael Wilhelm and John Wright and Nieuwenhuijsen, {Mark J} and G{\"o}ran Pershagen and Bert Brunekreef and Manolis Kogevinas and R{\'e}my Slama",

year = "2013",

month = nov,

doi = "10.1016/s2213-2600(13)70192-9",

language = "English",

volume = "1",

pages = "695--704",

journal = "The Lancet Respiratory Medicine",

issn = "2213-2600",

publisher = "The Lancet Publishing Group",

number = "9",

}

TY - JOUR

T1 - Ambient air pollution and low birthweight

T2 - a European cohort study (ESCAPE)

AU - Pedersen, Marie

AU - Giorgis-Allemand, Lise

AU - Bernard, Claire

AU - Aguilera, Inmaculada

AU - Andersen, Anne-Marie Nybo

AU - Ballester, Ferran

AU - Beelen, Rob M J

AU - Chatzi, Leda

AU - Cirach, Marta

AU - Danileviciute, Asta

AU - Dedele, Audrius

AU - Eijsden, Manon van

AU - Estarlich, Marisa

AU - Fernández-Somoano, Ana

AU - Fernández, Mariana F

AU - Forastiere, Francesco

AU - Gehring, Ulrike

AU - Grazuleviciene, Regina

AU - Gruzieva, Olena

AU - Heude, Barbara

AU - Hoek, Gerard

AU - de Hoogh, Kees

AU - van den Hooven, Edith H

AU - Håberg, Siri E

AU - Jaddoe, Vincent W V

AU - Klümper, Claudia

AU - Korek, Michal

AU - Krämer, Ursula

AU - Lerchundi, Aitana

AU - Lepeule, Johanna

AU - Nafstad, Per

AU - Nystad, Wenche

AU - Patelarou, Evridiki

AU - Porta, Daniela

AU - Postma, Dirkje

AU - Raaschou-Nielsen, Ole

AU - Rudnai, Peter

AU - Sunyer, Jordi

AU - Stephanou, Euripides

AU - Sørensen, Mette

AU - Thiering, Elisabeth

AU - Tuffnell, Derek

AU - Varró, Mihály J

AU - Vrijkotte, Tanja G M

AU - Wijga, Alet

AU - Wilhelm, Michael

AU - Wright, John

AU - Nieuwenhuijsen, Mark J

AU - Pershagen, Göran

AU - Brunekreef, Bert

AU - Kogevinas, Manolis

AU - Slama, Rémy

PY - 2013/11

Y1 - 2013/11

N2 - Background: Ambient air pollution has been associated with restricted fetal growth, which is linked with adverse respiratory health in childhood. We assessed the effect of maternal exposure to low concentrations of ambient air pollution on birthweight. Methods: We pooled data from 14 population-based mother-child cohort studies in 12 European countries. Overall, the study population included 74178 women who had singleton deliveries between Feb 11, 1994, and June 2, 2011, and for whom information about infant birthweight, gestational age, and sex was available. The primary outcome of interest was low birthweight at term (weight <2500 g at birth after 37 weeks of gestation). Mean concentrations of particulate matter with an aerodynamic diameter of less than 25 μm (PM25), less than 10 μm (PM10), and between 25 μm and 10 μm during pregnancy were estimated at maternal home addresses with temporally adjusted land-use regression models, as was PM25 absorbance and concentrations of nitrogen dioxide (NO2) and nitrogen oxides. We also investigated traffic density on the nearest road and total traffic load. We calculated pooled effect estimates with random-effects models. Findings: A 5 μg/m3 increase in concentration of PM25 during pregnancy was associated with an increased risk of low birthweight at term (adjusted odds ratio [OR] 118, 95% CI 106-133). An increased risk was also recorded for pregnancy concentrations lower than the present European Union annual PM25 limit of 25 μg/m3 (OR for 5 μg/m3 increase in participants exposed to concentrations of less than 20 μg/m3 141, 95% CI 120-165). PM10 (OR for 10 μg/m3 increase 116, 95% CI 100-135), NO2 (OR for 10 μg/m3 increase 109, 100-119), and traffic density on nearest street (OR for increase of 5000 vehicles per day 106, 101-111) were also associated with increased risk of low birthweight at term. The population attributable risk estimated for a reduction in PM25 concentration to 10 μg/m3 during pregnancy corresponded to a decrease of 22% (95% CI 8-33%) in cases of low birthweight at term. Interpretation: Exposure to ambient air pollutants and traffic during pregnancy is associated with restricted fetal growth. A substantial proportion of cases of low birthweight at term could be prevented in Europe if urban air pollution was reduced. Funding: The European Union.

AB - Background: Ambient air pollution has been associated with restricted fetal growth, which is linked with adverse respiratory health in childhood. We assessed the effect of maternal exposure to low concentrations of ambient air pollution on birthweight. Methods: We pooled data from 14 population-based mother-child cohort studies in 12 European countries. Overall, the study population included 74178 women who had singleton deliveries between Feb 11, 1994, and June 2, 2011, and for whom information about infant birthweight, gestational age, and sex was available. The primary outcome of interest was low birthweight at term (weight <2500 g at birth after 37 weeks of gestation). Mean concentrations of particulate matter with an aerodynamic diameter of less than 25 μm (PM25), less than 10 μm (PM10), and between 25 μm and 10 μm during pregnancy were estimated at maternal home addresses with temporally adjusted land-use regression models, as was PM25 absorbance and concentrations of nitrogen dioxide (NO2) and nitrogen oxides. We also investigated traffic density on the nearest road and total traffic load. We calculated pooled effect estimates with random-effects models. Findings: A 5 μg/m3 increase in concentration of PM25 during pregnancy was associated with an increased risk of low birthweight at term (adjusted odds ratio [OR] 118, 95% CI 106-133). An increased risk was also recorded for pregnancy concentrations lower than the present European Union annual PM25 limit of 25 μg/m3 (OR for 5 μg/m3 increase in participants exposed to concentrations of less than 20 μg/m3 141, 95% CI 120-165). PM10 (OR for 10 μg/m3 increase 116, 95% CI 100-135), NO2 (OR for 10 μg/m3 increase 109, 100-119), and traffic density on nearest street (OR for increase of 5000 vehicles per day 106, 101-111) were also associated with increased risk of low birthweight at term. The population attributable risk estimated for a reduction in PM25 concentration to 10 μg/m3 during pregnancy corresponded to a decrease of 22% (95% CI 8-33%) in cases of low birthweight at term. Interpretation: Exposure to ambient air pollutants and traffic during pregnancy is associated with restricted fetal growth. A substantial proportion of cases of low birthweight at term could be prevented in Europe if urban air pollution was reduced. Funding: The European Union.

KW - Adult

KW - Air Pollution

KW - Birth Weight

KW - Environmental Exposure

KW - Environmental Illness

KW - Environmental Monitoring

KW - Europe

KW - Female

KW - Humans

KW - Incidence

KW - Infant, Low Birth Weight

KW - Infant, Newborn

KW - Male

KW - Maternal Exposure

KW - Particulate Matter

KW - Pregnancy

KW - Young Adult

U2 - 10.1016/s2213-2600(13)70192-9

DO - 10.1016/s2213-2600(13)70192-9

M3 - Journal article

C2 - 24429273

SN - 2213-2600

VL - 1

SP - 695

EP - 704

JO - The Lancet Respiratory Medicine

JF - The Lancet Respiratory Medicine

IS - 9

ER -

Ambient air pollution and low birthweight: a European cohort study (ESCAPE)

Abstract

Keywords

UN SDGs

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