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Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites
Per Plenge,
Ulrik Gether
,
Søren G Rasmussen
Department of Neuroscience
Neuropharm and Genetics
43
Citations (Scopus)
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Keyphrases
5-hydroxytryptamine
66%
Allosteric Site
83%
Attenuation
16%
Binding Ability
16%
Binding Site
16%
Citalopram
100%
Conformational Change
16%
COS-7 Cells
16%
Dissociation
50%
Dissociation Rate
16%
High Affinity
100%
High-affinity Binding
16%
Imipramine
33%
Inhibitor Binding
16%
Low Affinity
16%
Low-affinity Binding Sites
100%
Orthosteric
16%
Paroxetine
50%
Severely Affected
16%
Uptake Inhibitor
50%
Biochemistry, Genetics and Molecular Biology
Allosteric Regulation
100%
Allosteric Site
50%
Binding Affinity
10%
Binding Site
100%
Citalopram
100%
Conformational Change
10%
Enantiomer
10%
Paroxetine
30%
Serotonin Transporter
100%
Wild Type
50%
Neuroscience
Binding Affinity
10%
Binding Site
100%
Citalopram
100%
Imipramine
20%
Paroxetine
30%
Serotonin Transporter
100%