Allergen-containing immune complexes used for immunotherapy of allergic asthma. Preparation of complexes and evaluation of their clinical performance in guinea pigs

L K Poulsen; L Lundberg; I Søndergaard; B Weeke

Allergen-containing immune complexes used for immunotherapy of allergic asthma. Preparation of complexes and evaluation of their clinical performance in guinea pigs

L K Poulsen, L Lundberg, I Søndergaard, B Weeke

Department of Clinical Medicine

5 Citations (Scopus)

Abstract

Guinea pigs inbred for their ability to develop respiratory anaphylaxis to experimental antigens have been used for comparison of different forms of immunotherapy (IT). Passive, active and combined (immune complexes between antigen and specific IgG) IT were compared with placebo. The bronchial reactivity of the animals to the antigen was monitored regularly before, during (35 weeks) and after IT (20 weeks). Animals treated with passive IT did not improve clinically. Active and combined IT abolished most symptoms within 7 weeks of treatment. During the post-treatment period, animals from both groups surprisingly recovered their original sensitivity to inhalation of the antigen.

Original language	English
Journal	Allergy
Volume	44
Issue number	2
Pages (from-to)	132-42
Number of pages	11
ISSN	0105-4538
Publication status	Published - Feb 1989

Keywords

Allergens
Animals
Antigen-Antibody Complex
Antigen-Antibody Reactions
Asthma
Bronchial Provocation Tests
Chromatography, Affinity
Desensitization, Immunologic
Evaluation Studies as Topic
Guinea Pigs
Immunoglobulin G
Ovalbumin
Journal Article
Research Support, Non-U.S. Gov't

Cite this

@article{cffb604f86c048cb95e95aa8a0d80d90,

title = "Allergen-containing immune complexes used for immunotherapy of allergic asthma. Preparation of complexes and evaluation of their clinical performance in guinea pigs",

abstract = "Guinea pigs inbred for their ability to develop respiratory anaphylaxis to experimental antigens have been used for comparison of different forms of immunotherapy (IT). Passive, active and combined (immune complexes between antigen and specific IgG) IT were compared with placebo. The bronchial reactivity of the animals to the antigen was monitored regularly before, during (35 weeks) and after IT (20 weeks). Animals treated with passive IT did not improve clinically. Active and combined IT abolished most symptoms within 7 weeks of treatment. During the post-treatment period, animals from both groups surprisingly recovered their original sensitivity to inhalation of the antigen.",

keywords = "Allergens, Animals, Antigen-Antibody Complex, Antigen-Antibody Reactions, Asthma, Bronchial Provocation Tests, Chromatography, Affinity, Desensitization, Immunologic, Evaluation Studies as Topic, Guinea Pigs, Immunoglobulin G, Ovalbumin, Journal Article, Research Support, Non-U.S. Gov't",

author = "Poulsen, {L K} and L Lundberg and I S{\o}ndergaard and B Weeke",

year = "1989",

month = feb,

language = "English",

volume = "44",

pages = "132--42",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

issn = "0105-4538",

publisher = "Wiley Online",

number = "2",

}

TY - JOUR

T1 - Allergen-containing immune complexes used for immunotherapy of allergic asthma. Preparation of complexes and evaluation of their clinical performance in guinea pigs

AU - Poulsen, L K

AU - Lundberg, L

AU - Søndergaard, I

AU - Weeke, B

PY - 1989/2

Y1 - 1989/2

N2 - Guinea pigs inbred for their ability to develop respiratory anaphylaxis to experimental antigens have been used for comparison of different forms of immunotherapy (IT). Passive, active and combined (immune complexes between antigen and specific IgG) IT were compared with placebo. The bronchial reactivity of the animals to the antigen was monitored regularly before, during (35 weeks) and after IT (20 weeks). Animals treated with passive IT did not improve clinically. Active and combined IT abolished most symptoms within 7 weeks of treatment. During the post-treatment period, animals from both groups surprisingly recovered their original sensitivity to inhalation of the antigen.

AB - Guinea pigs inbred for their ability to develop respiratory anaphylaxis to experimental antigens have been used for comparison of different forms of immunotherapy (IT). Passive, active and combined (immune complexes between antigen and specific IgG) IT were compared with placebo. The bronchial reactivity of the animals to the antigen was monitored regularly before, during (35 weeks) and after IT (20 weeks). Animals treated with passive IT did not improve clinically. Active and combined IT abolished most symptoms within 7 weeks of treatment. During the post-treatment period, animals from both groups surprisingly recovered their original sensitivity to inhalation of the antigen.

KW - Allergens

KW - Animals

KW - Antigen-Antibody Complex

KW - Antigen-Antibody Reactions

KW - Asthma

KW - Bronchial Provocation Tests

KW - Chromatography, Affinity

KW - Desensitization, Immunologic

KW - Evaluation Studies as Topic

KW - Guinea Pigs

KW - Immunoglobulin G

KW - Ovalbumin

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 2719179

SN - 0105-4538

VL - 44

SP - 132

EP - 142

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 2

ER -

Allergen-containing immune complexes used for immunotherapy of allergic asthma. Preparation of complexes and evaluation of their clinical performance in guinea pigs

Abstract

Keywords

Fingerprint

Cite this