Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

Christina Andersen; Helle Bach Søndergaard; Ditte Bang Oturai; Julie Hejgaard Laursen; Stefan Gustavsen; Nanna Katrine Larsen; Melinda Magyari; Emilie Just-Østergaard; Lise Wegner Thørner; Finn Sellebjerg; Henrik Ullum; Annette Bang Oturai

doi:10.1177/1352458518795418

Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

Christina Andersen, Helle Bach Søndergaard, Ditte Bang Oturai, Julie Hejgaard Laursen, Stefan Gustavsen, Nanna Katrine Larsen, Melinda Magyari, Emilie Just-Østergaard, Lise Wegner Thørner, Finn Sellebjerg, Henrik Ullum, Annette Bang Oturai

2 Citations (Scopus)

Abstract

Background and objective: Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15–19 and the risk of developing MS. Methods: A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders. Results: We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women (p < 0.001) and men (p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95% confidence interval (CI): 0.47–0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95% CI: 0.38–0.62) and high consumption (OR = 0.57, 95% CI: 0.38–0.84). Men with low alcohol consumption had an OR of 0.69 (95% CI: 0.53–0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption. Conclusion: Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.

Original language	English
Journal	Multiple Sclerosis
Volume	25
Issue number	12
Pages (from-to)	1572–1579
Number of pages	8
ISSN	1352-4585
DOIs	https://doi.org/10.1177/1352458518795418
Publication status	Published - 1 Oct 2019

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Andersen, C., Søndergaard, H. B., Bang Oturai, D., Laursen, J. H., Gustavsen, S., Larsen, N. K., Magyari, M., Just-Østergaard, E., Thørner, L. W., Sellebjerg, F., Ullum, H., & Oturai, A. B. (2019). Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort. Multiple Sclerosis, 25(12), 1572–1579. https://doi.org/10.1177/1352458518795418

Andersen, C, Søndergaard, HB, Bang Oturai, D, Laursen, JH, Gustavsen, S, Larsen, NK, Magyari, M, Just-Østergaard, E, Thørner, LW, Sellebjerg, F, Ullum, H & Oturai, AB 2019, 'Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort', Multiple Sclerosis, vol. 25, no. 12, pp. 1572–1579. https://doi.org/10.1177/1352458518795418

@article{b48db3782c104a2091e40f7b865b3cfe,

title = "Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort",

abstract = "Background and objective: Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15–19 and the risk of developing MS. Methods: A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders. Results: We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women (p < 0.001) and men (p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95% confidence interval (CI): 0.47–0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95% CI: 0.38–0.62) and high consumption (OR = 0.57, 95% CI: 0.38–0.84). Men with low alcohol consumption had an OR of 0.69 (95% CI: 0.53–0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption. Conclusion: Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.",

author = "Christina Andersen and S{\o}ndergaard, {Helle Bach} and {Bang Oturai}, Ditte and Laursen, {Julie Hejgaard} and Stefan Gustavsen and Larsen, {Nanna Katrine} and Melinda Magyari and Emilie Just-{\O}stergaard and Th{\o}rner, {Lise Wegner} and Finn Sellebjerg and Henrik Ullum and Oturai, {Annette Bang}",

year = "2019",

month = oct,

day = "1",

doi = "10.1177/1352458518795418",

language = "English",

volume = "25",

pages = "1572–1579",

journal = "Multiple Sclerosis Journal",

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TY - JOUR

T1 - Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

AU - Andersen, Christina

AU - Søndergaard, Helle Bach

AU - Bang Oturai, Ditte

AU - Laursen, Julie Hejgaard

AU - Gustavsen, Stefan

AU - Larsen, Nanna Katrine

AU - Magyari, Melinda

AU - Just-Østergaard, Emilie

AU - Thørner, Lise Wegner

AU - Sellebjerg, Finn

AU - Ullum, Henrik

AU - Oturai, Annette Bang

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background and objective: Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15–19 and the risk of developing MS. Methods: A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders. Results: We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women (p < 0.001) and men (p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95% confidence interval (CI): 0.47–0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95% CI: 0.38–0.62) and high consumption (OR = 0.57, 95% CI: 0.38–0.84). Men with low alcohol consumption had an OR of 0.69 (95% CI: 0.53–0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption. Conclusion: Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.

AB - Background and objective: Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15–19 and the risk of developing MS. Methods: A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders. Results: We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women (p < 0.001) and men (p = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95% confidence interval (CI): 0.47–0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95% CI: 0.38–0.62) and high consumption (OR = 0.57, 95% CI: 0.38–0.84). Men with low alcohol consumption had an OR of 0.69 (95% CI: 0.53–0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption. Conclusion: Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.

U2 - 10.1177/1352458518795418

DO - 10.1177/1352458518795418

M3 - Journal article

C2 - 30124094

SN - 1352-4585

VL - 25

SP - 1572

EP - 1579

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 12

ER -

Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

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