Air-oxidized linalool-a frequent cause of fragrance contact allergy

Johanna Bråred Christensson; Klaus Ejner Andersen; Magnus Bruze; Jeanne D Johansen; Begoña Garcia-Bravo; Ana Gimenez Arnau; Chee-Leok Goh; Rosemary Nixon; Ian R White

doi:10.1111/j.1600-0536.2012.02134.x

Air-oxidized linalool-a frequent cause of fragrance contact allergy

Johanna Bråred Christensson, Klaus Ejner Andersen, Magnus Bruze, Jeanne D Johansen, Begoña Garcia-Bravo, Ana Gimenez Arnau, Chee-Leok Goh, Rosemary Nixon, Ian R White

76 Citations (Scopus)

Abstract

Background. Linalool is a common fragrance terpene that, in pure form, is not allergenic or is a very weak allergen. However, linalool autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a Swedish study, oxidized linalool 6.0% in petrolatum (pet.) gave 5% positive patch test reactions in 2500 dermatitis patients. Objectives. To investigate whether oxidized linalool 6%, with a stable concentration of the main haptens, the linalool hydroperoxides (Lin-OOHs) in pet., could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized linalool 6.0% (Lin-OOHs 1%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 6.9% (range 3-13%) of the patients showed positive patch test reactions to oxidized linalool. Doubtful reactions were found in 9.2% of the patients (range 0-36%). Few irritant reactions were seen. Conclusions. In an international setting, oxidized linalool has been shown to be a common allergen. Oxidized linalool 6.0% (Lin-OOHs 1%) pet. is a useful, standardized and stable tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized linalool would not have been informed of their fragrance allergy if this specific test had not been performed.

Original language	English
Journal	Contact Dermatitis
Volume	67
Issue number	5
Pages (from-to)	247-259
Number of pages	13
ISSN	0105-1873
DOIs	https://doi.org/10.1111/j.1600-0536.2012.02134.x
Publication status	Published - Nov 2012

Access to Document

10.1111/j.1600-0536.2012.02134.x

Cite this

@article{0882ed00cc5f4bf9b281b61bd3fe35e0,

title = "Air-oxidized linalool-a frequent cause of fragrance contact allergy",

abstract = "Background. Linalool is a common fragrance terpene that, in pure form, is not allergenic or is a very weak allergen. However, linalool autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a Swedish study, oxidized linalool 6.0% in petrolatum (pet.) gave 5% positive patch test reactions in 2500 dermatitis patients. Objectives. To investigate whether oxidized linalool 6%, with a stable concentration of the main haptens, the linalool hydroperoxides (Lin-OOHs) in pet., could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized linalool 6.0% (Lin-OOHs 1%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 6.9% (range 3-13%) of the patients showed positive patch test reactions to oxidized linalool. Doubtful reactions were found in 9.2% of the patients (range 0-36%). Few irritant reactions were seen. Conclusions. In an international setting, oxidized linalool has been shown to be a common allergen. Oxidized linalool 6.0% (Lin-OOHs 1%) pet. is a useful, standardized and stable tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized linalool would not have been informed of their fragrance allergy if this specific test had not been performed.",

author = "{Br{\aa}red Christensson}, Johanna and Andersen, {Klaus Ejner} and Magnus Bruze and Johansen, {Jeanne D} and Bego{\~n}a Garcia-Bravo and {Gimenez Arnau}, Ana and Chee-Leok Goh and Rosemary Nixon and White, {Ian R}",

note = "{\textcopyright} 2012 John Wiley & Sons A/S.",

year = "2012",

month = nov,

doi = "10.1111/j.1600-0536.2012.02134.x",

language = "English",

volume = "67",

pages = "247--259",

journal = "Contact Dermatitis",

issn = "0105-1873",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Air-oxidized linalool-a frequent cause of fragrance contact allergy

AU - Bråred Christensson, Johanna

AU - Andersen, Klaus Ejner

AU - Bruze, Magnus

AU - Johansen, Jeanne D

AU - Garcia-Bravo, Begoña

AU - Gimenez Arnau, Ana

AU - Goh, Chee-Leok

AU - Nixon, Rosemary

AU - White, Ian R

PY - 2012/11

Y1 - 2012/11

N2 - Background. Linalool is a common fragrance terpene that, in pure form, is not allergenic or is a very weak allergen. However, linalool autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a Swedish study, oxidized linalool 6.0% in petrolatum (pet.) gave 5% positive patch test reactions in 2500 dermatitis patients. Objectives. To investigate whether oxidized linalool 6%, with a stable concentration of the main haptens, the linalool hydroperoxides (Lin-OOHs) in pet., could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized linalool 6.0% (Lin-OOHs 1%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 6.9% (range 3-13%) of the patients showed positive patch test reactions to oxidized linalool. Doubtful reactions were found in 9.2% of the patients (range 0-36%). Few irritant reactions were seen. Conclusions. In an international setting, oxidized linalool has been shown to be a common allergen. Oxidized linalool 6.0% (Lin-OOHs 1%) pet. is a useful, standardized and stable tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized linalool would not have been informed of their fragrance allergy if this specific test had not been performed.

AB - Background. Linalool is a common fragrance terpene that, in pure form, is not allergenic or is a very weak allergen. However, linalool autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a Swedish study, oxidized linalool 6.0% in petrolatum (pet.) gave 5% positive patch test reactions in 2500 dermatitis patients. Objectives. To investigate whether oxidized linalool 6%, with a stable concentration of the main haptens, the linalool hydroperoxides (Lin-OOHs) in pet., could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized linalool 6.0% (Lin-OOHs 1%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 6.9% (range 3-13%) of the patients showed positive patch test reactions to oxidized linalool. Doubtful reactions were found in 9.2% of the patients (range 0-36%). Few irritant reactions were seen. Conclusions. In an international setting, oxidized linalool has been shown to be a common allergen. Oxidized linalool 6.0% (Lin-OOHs 1%) pet. is a useful, standardized and stable tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized linalool would not have been informed of their fragrance allergy if this specific test had not been performed.

U2 - 10.1111/j.1600-0536.2012.02134.x

DO - 10.1111/j.1600-0536.2012.02134.x

M3 - Journal article

C2 - 22906042

SN - 0105-1873

VL - 67

SP - 247

EP - 259

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 5

ER -

Air-oxidized linalool-a frequent cause of fragrance contact allergy

Abstract

Access to Document

Fingerprint

Cite this