Aids-relaterede non-Hodgkin-lymfomer. Klinisk billede og prognose

M Penkowa; P B Hansen

Aids-relaterede non-Hodgkin-lymfomer. Klinisk billede og prognose

Translated title of the contribution: AIDS-related non-Hodgkin lymphomas. Clinical picture and prognosis

M Penkowa, P B Hansen

Abstract

Patients infected with HIV are at high risk for developing non-Hodgkin's lymphomas (NHL). HIV-associated NHLs seem to be increasing in number. They consist of two major histopathological subtypes originating from B-lymphocytes: Burkitt-like lymphomas and diffuse large cell lymphomas. There seems to be a clear association between Epstein-Barr virus (EBV) and immunoblastic lymphomas (a subtype of large cell lymphomas) in AIDS patients. Patients with AIDS often have widespread disease at presentation and frequent involvement of extranodal sites (CNS, liver, bone marrow, the digestive tract and skin). The treatment of NHL in AIDS patients is controversial due to their poor response to chemotherapy as well as a tendency to develop severe hematological toxicity. Factors with a negative influence on the prognosis are: Extranodal localisation of NHL including CNS, CD4 count below 200 x 10(6)/l, platelet count below 130 x 10(9)/l, widespread symptoms of disease, presence of EBV in the lymphoma and immunoblastic histology.
Udgivelsesdato: 1998-Apr-27

Translated title of the contribution	AIDS-related non-Hodgkin lymphomas. Clinical picture and prognosis
Original language	Danish
Journal	Ugeskrift for læger
Volume	160
Issue number	18
Pages (from-to)	2685-8
Number of pages	3
ISSN	0041-5782
Publication status	Published - 1998

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Cite this

@article{64e78df0832c11de8bc9000ea68e967b,

title = "Aids-relaterede non-Hodgkin-lymfomer. Klinisk billede og prognose",

abstract = "Patients infected with HIV are at high risk for developing non-Hodgkin's lymphomas (NHL). HIV-associated NHLs seem to be increasing in number. They consist of two major histopathological subtypes originating from B-lymphocytes: Burkitt-like lymphomas and diffuse large cell lymphomas. There seems to be a clear association between Epstein-Barr virus (EBV) and immunoblastic lymphomas (a subtype of large cell lymphomas) in AIDS patients. Patients with AIDS often have widespread disease at presentation and frequent involvement of extranodal sites (CNS, liver, bone marrow, the digestive tract and skin). The treatment of NHL in AIDS patients is controversial due to their poor response to chemotherapy as well as a tendency to develop severe hematological toxicity. Factors with a negative influence on the prognosis are: Extranodal localisation of NHL including CNS, CD4 count below 200 x 10(6)/l, platelet count below 130 x 10(9)/l, widespread symptoms of disease, presence of EBV in the lymphoma and immunoblastic histology. Udgivelsesdato: 1998-Apr-27",

author = "M Penkowa and Hansen, {P B}",

note = "Keywords: Humans; Lymphoma, AIDS-Related; Lymphoma, Non-Hodgkin; Prognosis",

year = "1998",

language = "Dansk",

volume = "160",

pages = "2685--8",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "18",

}

TY - JOUR

T1 - Aids-relaterede non-Hodgkin-lymfomer. Klinisk billede og prognose

AU - Penkowa, M

AU - Hansen, P B

N1 - Keywords: Humans; Lymphoma, AIDS-Related; Lymphoma, Non-Hodgkin; Prognosis

PY - 1998

Y1 - 1998

N2 - Patients infected with HIV are at high risk for developing non-Hodgkin's lymphomas (NHL). HIV-associated NHLs seem to be increasing in number. They consist of two major histopathological subtypes originating from B-lymphocytes: Burkitt-like lymphomas and diffuse large cell lymphomas. There seems to be a clear association between Epstein-Barr virus (EBV) and immunoblastic lymphomas (a subtype of large cell lymphomas) in AIDS patients. Patients with AIDS often have widespread disease at presentation and frequent involvement of extranodal sites (CNS, liver, bone marrow, the digestive tract and skin). The treatment of NHL in AIDS patients is controversial due to their poor response to chemotherapy as well as a tendency to develop severe hematological toxicity. Factors with a negative influence on the prognosis are: Extranodal localisation of NHL including CNS, CD4 count below 200 x 10(6)/l, platelet count below 130 x 10(9)/l, widespread symptoms of disease, presence of EBV in the lymphoma and immunoblastic histology. Udgivelsesdato: 1998-Apr-27

AB - Patients infected with HIV are at high risk for developing non-Hodgkin's lymphomas (NHL). HIV-associated NHLs seem to be increasing in number. They consist of two major histopathological subtypes originating from B-lymphocytes: Burkitt-like lymphomas and diffuse large cell lymphomas. There seems to be a clear association between Epstein-Barr virus (EBV) and immunoblastic lymphomas (a subtype of large cell lymphomas) in AIDS patients. Patients with AIDS often have widespread disease at presentation and frequent involvement of extranodal sites (CNS, liver, bone marrow, the digestive tract and skin). The treatment of NHL in AIDS patients is controversial due to their poor response to chemotherapy as well as a tendency to develop severe hematological toxicity. Factors with a negative influence on the prognosis are: Extranodal localisation of NHL including CNS, CD4 count below 200 x 10(6)/l, platelet count below 130 x 10(9)/l, widespread symptoms of disease, presence of EBV in the lymphoma and immunoblastic histology. Udgivelsesdato: 1998-Apr-27

M3 - Tidsskriftartikel

C2 - 9599550

SN - 0041-5782

VL - 160

SP - 2685

EP - 2688

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 18

ER -