Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort

EuroSIDA Study

doi:10.1097/QAD.0000000000001967

Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort

EuroSIDA Study

Department of Clinical Medicine

28 Citations (Scopus)

Abstract

Objectives: To describe changes in the prevalence of comorbidities and risk factors among HIV-positive individuals in the EuroSIDA study. Design: Comparison of two cross-sectional cohorts of HIV-positive adults under active follow-up in 2006 and 2014. Methods: Baseline demographics and prevalence of comorbidities were described. Factors associated with the prevalence of chronic kidney disease (CKD) and cardiovascular disease (CVD) were assessed by logistic regression modelling using generalized estimating equations. Results: Nine thousand, seven hundred and ninety-eight individuals were under active follow-up in EuroSIDA during 2006 and 12 882 during 2014. Compared with study participants in 2006, those in 2014 were older [median age 48.6 years (IQR 40.3 55.1) vs. 43.1 years (37.2 50.0) in 2006] and had higher prevalence of hypertension (59.6 vs. 47% in 2006), diabetes (6.3 vs. 5.4%), CKD (6.9 vs. 4.1%) and CVD (5.0 vs. 3.7%). Individuals in the 2014 cohort had higher odds for CKD (unadjusted OR 2.62, 95% CI 2.30 2.99, P0.0001) and CVD (OR 1.88, CI 1.68 2.10, P0.0001), but after multivariable adjustment for age group, comorbidities and other factors, year of cohort was no longer significantly associated with the odds of CKD [adjusted OR (aOR) 0.97, CI 0.52 1.82, P 0.92) or of CVD (aOR 0.94, CI 0.54 1.63, P 0.82). aCentre for Clinica Conclusion: Between 2006 and 2014, the population aged and experienced an overall higher prevalence of non-AIDS comorbidities, including CKD and CVD. The increase in CVD could be explained by the aging population, and the increase in CKD by aging and changes in other factors. Treatment strategies balancing HIV outcomes with long-Term management of comorbidities remain a priority.

Original language	English
Journal	AIDS
Volume	32
Issue number	16
Pages (from-to)	2405-2416
Number of pages	12
ISSN	0269-9370
DOIs	https://doi.org/10.1097/QAD.0000000000001967
Publication status	Published - 23 Oct 2018

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@article{cb0d38857ce040d19d9c898e019c900f,

title = "Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort",

abstract = "Objectives: To describe changes in the prevalence of comorbidities and risk factors among HIV-positive individuals in the EuroSIDA study. Design: Comparison of two cross-sectional cohorts of HIV-positive adults under active follow-up in 2006 and 2014. Methods: Baseline demographics and prevalence of comorbidities were described. Factors associated with the prevalence of chronic kidney disease (CKD) and cardiovascular disease (CVD) were assessed by logistic regression modelling using generalized estimating equations. Results: Nine thousand, seven hundred and ninety-eight individuals were under active follow-up in EuroSIDA during 2006 and 12 882 during 2014. Compared with study participants in 2006, those in 2014 were older [median age 48.6 years (IQR 40.3 55.1) vs. 43.1 years (37.2 50.0) in 2006] and had higher prevalence of hypertension (59.6 vs. 47% in 2006), diabetes (6.3 vs. 5.4%), CKD (6.9 vs. 4.1%) and CVD (5.0 vs. 3.7%). Individuals in the 2014 cohort had higher odds for CKD (unadjusted OR 2.62, 95% CI 2.30 2.99, P0.0001) and CVD (OR 1.88, CI 1.68 2.10, P0.0001), but after multivariable adjustment for age group, comorbidities and other factors, year of cohort was no longer significantly associated with the odds of CKD [adjusted OR (aOR) 0.97, CI 0.52 1.82, P 0.92) or of CVD (aOR 0.94, CI 0.54 1.63, P 0.82). aCentre for Clinica Conclusion: Between 2006 and 2014, the population aged and experienced an overall higher prevalence of non-AIDS comorbidities, including CKD and CVD. The increase in CVD could be explained by the aging population, and the increase in CKD by aging and changes in other factors. Treatment strategies balancing HIV outcomes with long-Term management of comorbidities remain a priority. ",

author = "Annegret Pelchen-Matthews and Lene Ryom and Borges, {{\'A}lvaro H} and Simon Edwards and Claudine Duvivier and Christoph Stephan and Helen Sambatakou and Katarzyna Maciejewska and Portu, {Jos{\'e} Joaqu{\'i}n} and Jonathan Weber and Olaf Degen and Alexandra Calmy and Reikvam, {Dag Henrik} and Djordje Jevtovic and Lothar Wiese and Jelena Smidt and Tomasz Smiatacz and Gamal Hassoun and Anastasiia Kuznetsova and Bonaventura Clotet and Jens Lundgren and Amanda Mocroft and {EuroSIDA Study}",

year = "2018",

month = oct,

day = "23",

doi = "10.1097/QAD.0000000000001967",

language = "English",

volume = "32",

pages = "2405--2416",

journal = "AIDS, Supplement",

issn = "1350-2840",

publisher = "Lippincott Williams & Wilkins",

number = "16",

}

TY - JOUR

T1 - Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort

AU - Pelchen-Matthews, Annegret

AU - Ryom, Lene

AU - Borges, Álvaro H

AU - Edwards, Simon

AU - Duvivier, Claudine

AU - Stephan, Christoph

AU - Sambatakou, Helen

AU - Maciejewska, Katarzyna

AU - Portu, José Joaquín

AU - Weber, Jonathan

AU - Degen, Olaf

AU - Calmy, Alexandra

AU - Reikvam, Dag Henrik

AU - Jevtovic, Djordje

AU - Wiese, Lothar

AU - Smidt, Jelena

AU - Smiatacz, Tomasz

AU - Hassoun, Gamal

AU - Kuznetsova, Anastasiia

AU - Clotet, Bonaventura

AU - Lundgren, Jens

AU - Mocroft, Amanda

AU - EuroSIDA Study

PY - 2018/10/23

Y1 - 2018/10/23

N2 - Objectives: To describe changes in the prevalence of comorbidities and risk factors among HIV-positive individuals in the EuroSIDA study. Design: Comparison of two cross-sectional cohorts of HIV-positive adults under active follow-up in 2006 and 2014. Methods: Baseline demographics and prevalence of comorbidities were described. Factors associated with the prevalence of chronic kidney disease (CKD) and cardiovascular disease (CVD) were assessed by logistic regression modelling using generalized estimating equations. Results: Nine thousand, seven hundred and ninety-eight individuals were under active follow-up in EuroSIDA during 2006 and 12 882 during 2014. Compared with study participants in 2006, those in 2014 were older [median age 48.6 years (IQR 40.3 55.1) vs. 43.1 years (37.2 50.0) in 2006] and had higher prevalence of hypertension (59.6 vs. 47% in 2006), diabetes (6.3 vs. 5.4%), CKD (6.9 vs. 4.1%) and CVD (5.0 vs. 3.7%). Individuals in the 2014 cohort had higher odds for CKD (unadjusted OR 2.62, 95% CI 2.30 2.99, P0.0001) and CVD (OR 1.88, CI 1.68 2.10, P0.0001), but after multivariable adjustment for age group, comorbidities and other factors, year of cohort was no longer significantly associated with the odds of CKD [adjusted OR (aOR) 0.97, CI 0.52 1.82, P 0.92) or of CVD (aOR 0.94, CI 0.54 1.63, P 0.82). aCentre for Clinica Conclusion: Between 2006 and 2014, the population aged and experienced an overall higher prevalence of non-AIDS comorbidities, including CKD and CVD. The increase in CVD could be explained by the aging population, and the increase in CKD by aging and changes in other factors. Treatment strategies balancing HIV outcomes with long-Term management of comorbidities remain a priority.

AB - Objectives: To describe changes in the prevalence of comorbidities and risk factors among HIV-positive individuals in the EuroSIDA study. Design: Comparison of two cross-sectional cohorts of HIV-positive adults under active follow-up in 2006 and 2014. Methods: Baseline demographics and prevalence of comorbidities were described. Factors associated with the prevalence of chronic kidney disease (CKD) and cardiovascular disease (CVD) were assessed by logistic regression modelling using generalized estimating equations. Results: Nine thousand, seven hundred and ninety-eight individuals were under active follow-up in EuroSIDA during 2006 and 12 882 during 2014. Compared with study participants in 2006, those in 2014 were older [median age 48.6 years (IQR 40.3 55.1) vs. 43.1 years (37.2 50.0) in 2006] and had higher prevalence of hypertension (59.6 vs. 47% in 2006), diabetes (6.3 vs. 5.4%), CKD (6.9 vs. 4.1%) and CVD (5.0 vs. 3.7%). Individuals in the 2014 cohort had higher odds for CKD (unadjusted OR 2.62, 95% CI 2.30 2.99, P0.0001) and CVD (OR 1.88, CI 1.68 2.10, P0.0001), but after multivariable adjustment for age group, comorbidities and other factors, year of cohort was no longer significantly associated with the odds of CKD [adjusted OR (aOR) 0.97, CI 0.52 1.82, P 0.92) or of CVD (aOR 0.94, CI 0.54 1.63, P 0.82). aCentre for Clinica Conclusion: Between 2006 and 2014, the population aged and experienced an overall higher prevalence of non-AIDS comorbidities, including CKD and CVD. The increase in CVD could be explained by the aging population, and the increase in CKD by aging and changes in other factors. Treatment strategies balancing HIV outcomes with long-Term management of comorbidities remain a priority.

U2 - 10.1097/QAD.0000000000001967

DO - 10.1097/QAD.0000000000001967

M3 - Journal article

C2 - 30134296

SN - 1350-2840

VL - 32

SP - 2405

EP - 2416

JO - AIDS, Supplement

JF - AIDS, Supplement

IS - 16

ER -

Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort

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