Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

Anat Milman; Antoine Andorin; Jean-Baptiste Gourraud; Frederic Sacher; Philippe Mabo; Sung-Hwan Kim; Shingo Maeda; Yoshihide Takahashi; Tsukasa Kamakura; Takeshi Aiba; Giulio Conte; Jimmy J M Juang; Eran Leshem; Michael Rahkovich; Aviram Hochstadt; Yuka Mizusawa; Pieter G Postema; Elena Arbelo; Zhengrong Huang; Isabelle Denjoy; Carla Giustetto; Yanushi D Wijeyeratne; Carlo Napolitano; Yoav Michowitz; Ramon Brugada; Ruben Casado-Arroyo; Jean Champagne; Leonardo Calo; Georgia Sarquella-Brugada; Jacob Tfelt-Hansen; Silvia G Priori; Masahiko Takagi; Christian Veltmann; Pietro Delise; Domenico Corrado; Elijah R Behr; Fiorenzo Gaita; Gan-Xin Yan; Josep Brugada; Antoine Leenhardt; Arthur A M Wilde; Pedro Brugada; Kengo F Kusano; Kenzo Hirao; Gi-Byoung Nam; Vincent Probst; Bernard Belhassen

doi:10.1161/CIRCEP.117.005222

Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

Anat Milman, Antoine Andorin, Jean-Baptiste Gourraud, Frederic Sacher, Philippe Mabo, Sung-Hwan Kim, Shingo Maeda, Yoshihide Takahashi, Tsukasa Kamakura, Takeshi Aiba, Giulio Conte, Jimmy J M Juang, Eran Leshem, Michael Rahkovich, Aviram Hochstadt, Yuka Mizusawa, Pieter G Postema, Elena Arbelo, Zhengrong Huang, Isabelle DenjoyCarla Giustetto, Yanushi D Wijeyeratne, Carlo Napolitano, Yoav Michowitz, Ramon Brugada, Ruben Casado-Arroyo, Jean Champagne, Leonardo Calo, Georgia Sarquella-Brugada, Jacob Tfelt-Hansen, Silvia G Priori, Masahiko Takagi, Christian Veltmann, Pietro Delise, Domenico Corrado, Elijah R Behr, Fiorenzo Gaita, Gan-Xin Yan, Josep Brugada, Antoine Leenhardt, Arthur A M Wilde, Pedro Brugada, Kengo F Kusano, Kenzo Hirao, Gi-Byoung Nam, Vincent Probst, Bernard Belhassen

Department of Clinical Medicine

22 Citations (Scopus)

Abstract

Background Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the influence of the mode of AE documentation, sex, and ethnicity on the age at first AE. Methods and Results A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 patients with Brugada syndrome (91.3% men) with first AE documented at time of aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation (group B, n=252). The vast majority (94.2%) of the patients were 16 to 70 years old at the time of AE, whereas pediatric (<16 years) and elderly patients (>70 years) comprised 4.3% and 1.5%, respectively. Peak AE rate occurred between 38 and 48 years (mean, 41.9±14.8; range, 0.27-84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1±13.2 versus 39.4±15.0 years; P<0.001). In adult patients (≥16 years), women experienced AE 6.5 years later than men (P=0.003). Whites and Asians exhibited their AE at the same median age (43 years). Conclusions SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) presents the first analysis on the age distribution of AE in Brugada syndrome, suggesting 2 age cutoffs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient sex, and ethnic origin on the age at AE.

Original language	English
Article number	e005222
Journal	Circulation. Arrhythmia and electrophysiology
Volume	10
Issue number	12
Number of pages	19
ISSN	1941-3149
DOIs	https://doi.org/10.1161/CIRCEP.117.005222
Publication status	Published - 1 Dec 2017

Keywords

Adolescent
Adult
Age of Onset
Aged
Brugada Syndrome/physiopathology
Defibrillators, Implantable
Female
Humans
Male
Middle Aged
Prognosis

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10.1161/CIRCEP.117.005222

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Milman, A., Andorin, A., Gourraud, J.-B., Sacher, F., Mabo, P., Kim, S.-H., Maeda, S., Takahashi, Y., Kamakura, T., Aiba, T., Conte, G., Juang, J. J. M., Leshem, E., Rahkovich, M., Hochstadt, A., Mizusawa, Y., Postema, P. G., Arbelo, E., Huang, Z., ... Belhassen, B. (2017). Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients. Circulation. Arrhythmia and electrophysiology, 10(12), Article e005222. https://doi.org/10.1161/CIRCEP.117.005222

Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients. / Milman, Anat; Andorin, Antoine; Gourraud, Jean-Baptiste et al.
In: Circulation. Arrhythmia and electrophysiology, Vol. 10, No. 12, e005222, 01.12.2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Milman, A, Andorin, A, Gourraud, J-B, Sacher, F, Mabo, P, Kim, S-H, Maeda, S, Takahashi, Y, Kamakura, T, Aiba, T, Conte, G, Juang, JJM, Leshem, E, Rahkovich, M, Hochstadt, A, Mizusawa, Y, Postema, PG, Arbelo, E, Huang, Z, Denjoy, I, Giustetto, C, Wijeyeratne, YD, Napolitano, C, Michowitz, Y, Brugada, R, Casado-Arroyo, R, Champagne, J, Calo, L, Sarquella-Brugada, G, Tfelt-Hansen, J, Priori, SG, Takagi, M, Veltmann, C, Delise, P, Corrado, D, Behr, ER, Gaita, F, Yan, G-X, Brugada, J, Leenhardt, A, Wilde, AAM, Brugada, P, Kusano, KF, Hirao, K, Nam, G-B, Probst, V & Belhassen, B 2017, 'Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients', Circulation. Arrhythmia and electrophysiology, vol. 10, no. 12, e005222. https://doi.org/10.1161/CIRCEP.117.005222

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title = "Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients",

abstract = "Background Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the influence of the mode of AE documentation, sex, and ethnicity on the age at first AE. Methods and Results A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 patients with Brugada syndrome (91.3% men) with first AE documented at time of aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation (group B, n=252). The vast majority (94.2%) of the patients were 16 to 70 years old at the time of AE, whereas pediatric (<16 years) and elderly patients (>70 years) comprised 4.3% and 1.5%, respectively. Peak AE rate occurred between 38 and 48 years (mean, 41.9±14.8; range, 0.27-84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1±13.2 versus 39.4±15.0 years; P<0.001). In adult patients (≥16 years), women experienced AE 6.5 years later than men (P=0.003). Whites and Asians exhibited their AE at the same median age (43 years). Conclusions SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) presents the first analysis on the age distribution of AE in Brugada syndrome, suggesting 2 age cutoffs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient sex, and ethnic origin on the age at AE.",

keywords = "Adolescent, Adult, Age of Onset, Aged, Brugada Syndrome/physiopathology, Defibrillators, Implantable, Female, Humans, Male, Middle Aged, Prognosis",

author = "Anat Milman and Antoine Andorin and Jean-Baptiste Gourraud and Frederic Sacher and Philippe Mabo and Sung-Hwan Kim and Shingo Maeda and Yoshihide Takahashi and Tsukasa Kamakura and Takeshi Aiba and Giulio Conte and Juang, {Jimmy J M} and Eran Leshem and Michael Rahkovich and Aviram Hochstadt and Yuka Mizusawa and Postema, {Pieter G} and Elena Arbelo and Zhengrong Huang and Isabelle Denjoy and Carla Giustetto and Wijeyeratne, {Yanushi D} and Carlo Napolitano and Yoav Michowitz and Ramon Brugada and Ruben Casado-Arroyo and Jean Champagne and Leonardo Calo and Georgia Sarquella-Brugada and Jacob Tfelt-Hansen and Priori, {Silvia G} and Masahiko Takagi and Christian Veltmann and Pietro Delise and Domenico Corrado and Behr, {Elijah R} and Fiorenzo Gaita and Gan-Xin Yan and Josep Brugada and Antoine Leenhardt and Wilde, {Arthur A M} and Pedro Brugada and Kusano, {Kengo F} and Kenzo Hirao and Gi-Byoung Nam and Vincent Probst and Bernard Belhassen",

note = "{\textcopyright} 2017 American Heart Association, Inc.",

year = "2017",

month = dec,

day = "1",

doi = "10.1161/CIRCEP.117.005222",

language = "English",

volume = "10",

journal = "Circulation. Arrhythmia and electrophysiology",

issn = "1941-3149",

publisher = "Lippincott Williams & Wilkins",

number = "12",

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TY - JOUR

T1 - Age of First Arrhythmic Event in Brugada Syndrome

T2 - Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

AU - Milman, Anat

AU - Andorin, Antoine

AU - Gourraud, Jean-Baptiste

AU - Sacher, Frederic

AU - Mabo, Philippe

AU - Kim, Sung-Hwan

AU - Maeda, Shingo

AU - Takahashi, Yoshihide

AU - Kamakura, Tsukasa

AU - Aiba, Takeshi

AU - Conte, Giulio

AU - Juang, Jimmy J M

AU - Leshem, Eran

AU - Rahkovich, Michael

AU - Hochstadt, Aviram

AU - Mizusawa, Yuka

AU - Postema, Pieter G

AU - Arbelo, Elena

AU - Huang, Zhengrong

AU - Denjoy, Isabelle

AU - Giustetto, Carla

AU - Wijeyeratne, Yanushi D

AU - Napolitano, Carlo

AU - Michowitz, Yoav

AU - Brugada, Ramon

AU - Casado-Arroyo, Ruben

AU - Champagne, Jean

AU - Calo, Leonardo

AU - Sarquella-Brugada, Georgia

AU - Tfelt-Hansen, Jacob

AU - Priori, Silvia G

AU - Takagi, Masahiko

AU - Veltmann, Christian

AU - Delise, Pietro

AU - Corrado, Domenico

AU - Behr, Elijah R

AU - Gaita, Fiorenzo

AU - Yan, Gan-Xin

AU - Brugada, Josep

AU - Leenhardt, Antoine

AU - Wilde, Arthur A M

AU - Brugada, Pedro

AU - Kusano, Kengo F

AU - Hirao, Kenzo

AU - Nam, Gi-Byoung

AU - Probst, Vincent

AU - Belhassen, Bernard

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the influence of the mode of AE documentation, sex, and ethnicity on the age at first AE. Methods and Results A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 patients with Brugada syndrome (91.3% men) with first AE documented at time of aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation (group B, n=252). The vast majority (94.2%) of the patients were 16 to 70 years old at the time of AE, whereas pediatric (<16 years) and elderly patients (>70 years) comprised 4.3% and 1.5%, respectively. Peak AE rate occurred between 38 and 48 years (mean, 41.9±14.8; range, 0.27-84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1±13.2 versus 39.4±15.0 years; P<0.001). In adult patients (≥16 years), women experienced AE 6.5 years later than men (P=0.003). Whites and Asians exhibited their AE at the same median age (43 years). Conclusions SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) presents the first analysis on the age distribution of AE in Brugada syndrome, suggesting 2 age cutoffs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient sex, and ethnic origin on the age at AE.

AB - Background Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the influence of the mode of AE documentation, sex, and ethnicity on the age at first AE. Methods and Results A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 patients with Brugada syndrome (91.3% men) with first AE documented at time of aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation (group B, n=252). The vast majority (94.2%) of the patients were 16 to 70 years old at the time of AE, whereas pediatric (<16 years) and elderly patients (>70 years) comprised 4.3% and 1.5%, respectively. Peak AE rate occurred between 38 and 48 years (mean, 41.9±14.8; range, 0.27-84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1±13.2 versus 39.4±15.0 years; P<0.001). In adult patients (≥16 years), women experienced AE 6.5 years later than men (P=0.003). Whites and Asians exhibited their AE at the same median age (43 years). Conclusions SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) presents the first analysis on the age distribution of AE in Brugada syndrome, suggesting 2 age cutoffs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient sex, and ethnic origin on the age at AE.

KW - Adolescent

KW - Adult

KW - Age of Onset

KW - Aged

KW - Brugada Syndrome/physiopathology

KW - Defibrillators, Implantable

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

U2 - 10.1161/CIRCEP.117.005222

DO - 10.1161/CIRCEP.117.005222

M3 - Journal article

C2 - 29254945

SN - 1941-3149

VL - 10

JO - Circulation. Arrhythmia and electrophysiology

JF - Circulation. Arrhythmia and electrophysiology

IS - 12

M1 - e005222

ER -

Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

Abstract

Keywords

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