After treat-to-target: can a targeted ultrasound initiative improve RA outcomes?

Richard J Wakefield; Maria Antonietta D'Agostino; Esperanza Naredo; Maya H Buch; Annamaria Iagnocco; Lene Terslev; Mikkel Østergaard; Marina Backhaus; Walter Grassi; Maxime Dougados; Gerd R Burmester; Benazir Saleem; Eugenio de Miguel; Cristina Estrach; Kei Ikeda; Marwin Gutierrez; Eric Robert Thompson; Peter Balint; Paul Emery

doi:10.1136/annrheumdis-2011-201048

After treat-to-target: can a targeted ultrasound initiative improve RA outcomes?

Richard J Wakefield, Maria Antonietta D'Agostino, Esperanza Naredo, Maya H Buch, Annamaria Iagnocco, Lene Terslev, Mikkel Østergaard, Marina Backhaus, Walter Grassi, Maxime Dougados, Gerd R Burmester, Benazir Saleem, Eugenio de Miguel, Cristina Estrach, Kei Ikeda, Marwin Gutierrez, Eric Robert Thompson, Peter Balint, Paul Emery

85 Citations (Scopus)

Abstract

For patients with rheumatoid arthritis (RA), remission can be achieved with tight control of inflammation and early use of disease modifying agents. The importance of remission as an outcome has been recently highlighted by European League Against Rheumatism recommendations. However, remission when defined by clinical remission criteria (disease activity score, simplified disease activity index, etc) does not always equate to the complete absence of inflammation as measured by new sensitive imaging techniques such as ultrasound (US) . There is evidence that imaging synovitis is frequently found in these patients and associated with adverse clinical and functional outcomes. This article reviews the data regarding remission, ultrasound imaging and outcomes in patients with RA to provide the background to a consensus statement from an international collaboration of ultrasonographers and rheumatologists who have recently formed a research network--the Targeted Ultrasound Initiative (TUI) group. The statement proposes that targeting therapy to PD activity provides superior outcomes compared with treating to clinical targets alone and introduces the rationale for a new randomised trial using targeted ultrasound in RA.

Original language	English
Journal	Annals of the Rheumatic Diseases
Volume	71
Issue number	6
Pages (from-to)	799-803
Number of pages	5
ISSN	0003-4967
DOIs	https://doi.org/10.1136/annrheumdis-2011-201048
Publication status	Published - Jun 2012

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Wakefield, R. J., D'Agostino, M. A., Naredo, E., Buch, M. H., Iagnocco, A., Terslev, L., Østergaard, M., Backhaus, M., Grassi, W., Dougados, M., Burmester, G. R., Saleem, B., de Miguel, E., Estrach, C., Ikeda, K., Gutierrez, M., Thompson, E. R., Balint, P., & Emery, P. (2012). After treat-to-target: can a targeted ultrasound initiative improve RA outcomes? Annals of the Rheumatic Diseases, 71(6), 799-803. https://doi.org/10.1136/annrheumdis-2011-201048

Wakefield, RJ, D'Agostino, MA, Naredo, E, Buch, MH, Iagnocco, A, Terslev, L, Østergaard, M, Backhaus, M, Grassi, W, Dougados, M, Burmester, GR, Saleem, B, de Miguel, E, Estrach, C, Ikeda, K, Gutierrez, M, Thompson, ER, Balint, P & Emery, P 2012, 'After treat-to-target: can a targeted ultrasound initiative improve RA outcomes?', Annals of the Rheumatic Diseases, vol. 71, no. 6, pp. 799-803. https://doi.org/10.1136/annrheumdis-2011-201048

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title = "After treat-to-target: can a targeted ultrasound initiative improve RA outcomes?",

abstract = "For patients with rheumatoid arthritis (RA), remission can be achieved with tight control of inflammation and early use of disease modifying agents. The importance of remission as an outcome has been recently highlighted by European League Against Rheumatism recommendations. However, remission when defined by clinical remission criteria (disease activity score, simplified disease activity index, etc) does not always equate to the complete absence of inflammation as measured by new sensitive imaging techniques such as ultrasound (US) . There is evidence that imaging synovitis is frequently found in these patients and associated with adverse clinical and functional outcomes. This article reviews the data regarding remission, ultrasound imaging and outcomes in patients with RA to provide the background to a consensus statement from an international collaboration of ultrasonographers and rheumatologists who have recently formed a research network--the Targeted Ultrasound Initiative (TUI) group. The statement proposes that targeting therapy to PD activity provides superior outcomes compared with treating to clinical targets alone and introduces the rationale for a new randomised trial using targeted ultrasound in RA.",

author = "Wakefield, {Richard J} and D'Agostino, {Maria Antonietta} and Esperanza Naredo and Buch, {Maya H} and Annamaria Iagnocco and Lene Terslev and Mikkel {\O}stergaard and Marina Backhaus and Walter Grassi and Maxime Dougados and Burmester, {Gerd R} and Benazir Saleem and {de Miguel}, Eugenio and Cristina Estrach and Kei Ikeda and Marwin Gutierrez and Thompson, {Eric Robert} and Peter Balint and Paul Emery",

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AU - Wakefield, Richard J

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AU - Iagnocco, Annamaria

AU - Terslev, Lene

AU - Østergaard, Mikkel

AU - Backhaus, Marina

AU - Grassi, Walter

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AU - Burmester, Gerd R

AU - Saleem, Benazir

AU - de Miguel, Eugenio

AU - Estrach, Cristina

AU - Ikeda, Kei

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AU - Thompson, Eric Robert

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AU - Emery, Paul

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AB - For patients with rheumatoid arthritis (RA), remission can be achieved with tight control of inflammation and early use of disease modifying agents. The importance of remission as an outcome has been recently highlighted by European League Against Rheumatism recommendations. However, remission when defined by clinical remission criteria (disease activity score, simplified disease activity index, etc) does not always equate to the complete absence of inflammation as measured by new sensitive imaging techniques such as ultrasound (US) . There is evidence that imaging synovitis is frequently found in these patients and associated with adverse clinical and functional outcomes. This article reviews the data regarding remission, ultrasound imaging and outcomes in patients with RA to provide the background to a consensus statement from an international collaboration of ultrasonographers and rheumatologists who have recently formed a research network--the Targeted Ultrasound Initiative (TUI) group. The statement proposes that targeting therapy to PD activity provides superior outcomes compared with treating to clinical targets alone and introduces the rationale for a new randomised trial using targeted ultrasound in RA.

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JO - Annals of the Rheumatic Diseases

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ER -

After treat-to-target: can a targeted ultrasound initiative improve RA outcomes?

Abstract

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