Aerobic Training in Patients with Congenital Myopathy

TY - JOUR

T1 - Aerobic Training in Patients with Congenital Myopathy

AU - Hedermann, Gitte

AU - Vissing, Christoffer Rasmus

AU - Jensen, Karen

AU - Preisler, Nicolai

AU - Witting, Nanna

AU - Vissing, John

PY - 2016/1/11

Y1 - 2016/1/11

N2 - Introduction: Congenital myopathies (CM) often affect contractile proteins of the sarcomere, which could render patients susceptible to exercise-induced muscle damage. We investigated if exercise is safe and beneficial in patients with CM. Methods: Patients exercised on a stationary bike for 30 minutes, three times weekly, for 10 weeks at 70% of their maximal oxygen uptake (VO2max). Creatine kinase (CK) was monitored as a marker of muscle damage. VO2max, functional tests, and questionnaires evaluated efficacy. Results: Sixteen patients with CM were included in a controlled study. VO2max increased by 14% (range, 6-25%; 95%CI 7-20; p < 0.001) in the seven patients who completed training, and tended to decrease in a non-intervention group (n = 7; change -3.5%; range, -11-3%, p = 0.083). CK levels were normal and remained stable during training. Baseline Fatigue Severity Scale scores were high, 4.9 (SE 1.9), and tended to decrease (to 4.4 (SE 1.7); p = 0.08) with training. Nine patients dropped out of the training program. Fatigue was themajor single reason. Conclusions: Ten weeks of endurance training is safe and improves fitness in patients with congenital myopathies. The training did not cause sarcomeric injury, even though sarcomeric function is affected by the genetic abnormalities in most patients with CM. Severe fatigue, which characterizes patients with CM, is a limiting factor for initiating training in CM, but tends to improve in those who train.

AB - Introduction: Congenital myopathies (CM) often affect contractile proteins of the sarcomere, which could render patients susceptible to exercise-induced muscle damage. We investigated if exercise is safe and beneficial in patients with CM. Methods: Patients exercised on a stationary bike for 30 minutes, three times weekly, for 10 weeks at 70% of their maximal oxygen uptake (VO2max). Creatine kinase (CK) was monitored as a marker of muscle damage. VO2max, functional tests, and questionnaires evaluated efficacy. Results: Sixteen patients with CM were included in a controlled study. VO2max increased by 14% (range, 6-25%; 95%CI 7-20; p < 0.001) in the seven patients who completed training, and tended to decrease in a non-intervention group (n = 7; change -3.5%; range, -11-3%, p = 0.083). CK levels were normal and remained stable during training. Baseline Fatigue Severity Scale scores were high, 4.9 (SE 1.9), and tended to decrease (to 4.4 (SE 1.7); p = 0.08) with training. Nine patients dropped out of the training program. Fatigue was themajor single reason. Conclusions: Ten weeks of endurance training is safe and improves fitness in patients with congenital myopathies. The training did not cause sarcomeric injury, even though sarcomeric function is affected by the genetic abnormalities in most patients with CM. Severe fatigue, which characterizes patients with CM, is a limiting factor for initiating training in CM, but tends to improve in those who train.

KW - Adult

KW - Creatine Kinase

KW - Demography

KW - Exercise

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Muscle Strength

KW - Muscular Diseases

KW - Oxidation-Reduction

KW - Oxygen Consumption

KW - Patient Compliance

KW - Patient Dropouts

KW - Surveys and Questionnaires

KW - Vital Capacity

KW - Young Adult

KW - Clinical Trial

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1371/journal.pone.0146036

DO - 10.1371/journal.pone.0146036

M3 - Journal article

C2 - 26751952

SN - 1932-6203

VL - 11

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 1

M1 - e0146036

ER -