Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects

Josephine M Forbes; Karly C Sourris; Maximilian de Courten; Sonia L Dougherty; Vibhasha Chand; Jasmine G Lyons; David Bertovic; Melinda T Coughlan; Markus P Schlaich; Georgia Soldatos; Mark E Cooper; Nora E Straznicky; Bronwyn A Kingwell; Barbora de Courten

doi:10.1007/s00726-013-1542-9

Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects

Josephine M Forbes, Karly C Sourris, Maximilian de Courten, Sonia L Dougherty, Vibhasha Chand, Jasmine G Lyons, David Bertovic, Melinda T Coughlan, Markus P Schlaich, Georgia Soldatos, Mark E Cooper, Nora E Straznicky, Bronwyn A Kingwell, Barbora de Courten

Torekov Group

25 Citations (Scopus)

Abstract

It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 ± 10 years) with a wide range of BMI (24.6-31.0 kg/m(2)). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT (r = 0.43; p

Original language	English
Journal	Journal of Amino Acids
Volume	46
Issue number	2
Pages (from-to)	321-326
Number of pages	6
ISSN	2090-0112
DOIs	https://doi.org/10.1007/s00726-013-1542-9
Publication status	Published - Feb 2014

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Forbes, J. M., Sourris, K. C., de Courten, M., Dougherty, S. L., Chand, V., Lyons, J. G., Bertovic, D., Coughlan, M. T., Schlaich, M. P., Soldatos, G., Cooper, M. E., Straznicky, N. E., Kingwell, B. A., & de Courten, B. (2014). Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects. Journal of Amino Acids, 46(2), 321-326. https://doi.org/10.1007/s00726-013-1542-9

Forbes, JM, Sourris, KC, de Courten, M, Dougherty, SL, Chand, V, Lyons, JG, Bertovic, D, Coughlan, MT, Schlaich, MP, Soldatos, G, Cooper, ME, Straznicky, NE, Kingwell, BA & de Courten, B 2014, 'Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects', Journal of Amino Acids, vol. 46, no. 2, pp. 321-326. https://doi.org/10.1007/s00726-013-1542-9

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abstract = "It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 ± 10 years) with a wide range of BMI (24.6-31.0 kg/m(2)). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT (r = 0.43; p ",

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AU - Forbes, Josephine M

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AU - de Courten, Maximilian

AU - Dougherty, Sonia L

AU - Chand, Vibhasha

AU - Lyons, Jasmine G

AU - Bertovic, David

AU - Coughlan, Melinda T

AU - Schlaich, Markus P

AU - Soldatos, Georgia

AU - Cooper, Mark E

AU - Straznicky, Nora E

AU - Kingwell, Bronwyn A

AU - de Courten, Barbora

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N2 - It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 ± 10 years) with a wide range of BMI (24.6-31.0 kg/m(2)). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT (r = 0.43; p

AB - It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 ± 10 years) with a wide range of BMI (24.6-31.0 kg/m(2)). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT (r = 0.43; p

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Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects

Abstract

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