Adsorption of multimeric T cell antigens on carbon nanotubes: effect on protein structure and antigen-specific T cell stimulation

Tarek R Fadel; Nan Li; Smith Shah; Michael Look; Lisa D Pfefferle; Gary L Haller; Sune Justesen; Corey J Wilson; Tarek M Fahmy

doi:10.1002/smll.201201684

Adsorption of multimeric T cell antigens on carbon nanotubes: effect on protein structure and antigen-specific T cell stimulation

Tarek R Fadel, Nan Li, Smith Shah, Michael Look, Lisa D Pfefferle, Gary L Haller, Sune Justesen, Corey J Wilson, Tarek M Fahmy

30 Citations (Scopus)

Abstract

Antigen-specific activation of cytotoxic T cells can be enhanced up to three-fold more than soluble controls when using functionalized bundled carbon nanotube substrates ((b) CNTs). To overcome the denaturing effects of direct adsorption on (b) CNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non-covalent attachment of the linker neutravidin.

Original language	English
Journal	Small
Volume	9
Issue number	5
Pages (from-to)	666-72
Number of pages	7
DOIs	https://doi.org/10.1002/smll.201201684
Publication status	Published - 11 Mar 2013

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title = "Adsorption of multimeric T cell antigens on carbon nanotubes: effect on protein structure and antigen-specific T cell stimulation",

abstract = "Antigen-specific activation of cytotoxic T cells can be enhanced up to three-fold more than soluble controls when using functionalized bundled carbon nanotube substrates ((b) CNTs). To overcome the denaturing effects of direct adsorption on (b) CNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non-covalent attachment of the linker neutravidin.",

author = "Fadel, {Tarek R} and Nan Li and Smith Shah and Michael Look and Pfefferle, {Lisa D} and Haller, {Gary L} and Sune Justesen and Wilson, {Corey J} and Fahmy, {Tarek M}",

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T2 - effect on protein structure and antigen-specific T cell stimulation

AU - Fadel, Tarek R

AU - Li, Nan

AU - Shah, Smith

AU - Look, Michael

AU - Pfefferle, Lisa D

AU - Haller, Gary L

AU - Justesen, Sune

AU - Wilson, Corey J

AU - Fahmy, Tarek M

PY - 2013/3/11

Y1 - 2013/3/11

N2 - Antigen-specific activation of cytotoxic T cells can be enhanced up to three-fold more than soluble controls when using functionalized bundled carbon nanotube substrates ((b) CNTs). To overcome the denaturing effects of direct adsorption on (b) CNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non-covalent attachment of the linker neutravidin.

AB - Antigen-specific activation of cytotoxic T cells can be enhanced up to three-fold more than soluble controls when using functionalized bundled carbon nanotube substrates ((b) CNTs). To overcome the denaturing effects of direct adsorption on (b) CNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non-covalent attachment of the linker neutravidin.

U2 - 10.1002/smll.201201684

DO - 10.1002/smll.201201684

M3 - Journal article

C2 - 23090793

SN - 1613-6810

VL - 9

SP - 666

EP - 672

JO - Small

JF - Small

IS - 5

ER -

Adsorption of multimeric T cell antigens on carbon nanotubes: effect on protein structure and antigen-specific T cell stimulation

Abstract

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