Abstract
The present study aimed to investigate lymphocyte mobilization from peripheral cell reservoirs in HIV-infected patients. Nine HIV-infected patients on stable highly active anti-retroviral therapy (HAART), eight treatment-naive HIV-infected patients and eight HIV- controls received a 1-h adrenaline infusion. The adrenaline infusion induced a three-fold increase in the concentration of lymphocytes in all three groups. All HIV-infected patients mobilized significantly higher numbers of CD8+ cells but less CD4+ cells. All subjects mobilized CD45RA+CD62L+ and CD8+CD28+ cells to a lesser extent than CD45RO+CD45RA- and CD8+CD28-cells. Furthermore, high numbers of CD8+CD38+ cells were mobilized only in the HIV-infected patients. It was therefore predominantly T cells with an activated phenotype which were mobilized after adrenaline stimulation. It is concluded that the HIV-associated immune defect induced an impaired ability to mobilize immune-competent cells in response to stress stimuli. Furthermore, the study does not support the idea that CD4+ T cells are trapped in lymph nodes by HIV antigens, because untreated and HAART-treated HIV-infected patients mobilized similar numbers of CD4+ T cells. Finally, no evidence was found for the existence of a HAART-induced non-circulating pool of CD4+ T cells.
| Original language | English |
|---|---|
| Journal | Clinical and Experimental Immunology |
| Volume | 119 |
| Issue number | 1 |
| Pages (from-to) | 115-22 |
| Number of pages | 8 |
| ISSN | 0009-9104 |
| Publication status | Published - Jan 2000 |
Keywords
- ADP-ribosyl Cyclase
- Adult
- Anti-HIV Agents
- Antigens, CD
- Antigens, CD28
- Antigens, CD38
- Antigens, Differentiation
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Case-Control Studies
- Epinephrine
- Female
- HIV Infections
- Humans
- Male
- Membrane Glycoproteins
- Middle Aged
- NAD+ Nucleosidase
- T-Lymphocyte Subsets
- Journal Article
- Research Support, Non-U.S. Gov't
