Administering different levels of parenteral phosphate and amino acids did not influence growth in extremely preterm infants

TY - JOUR

T1 - Administering different levels of parenteral phosphate and amino acids did not influence growth in extremely preterm infants

AU - Thomsen, Katrine Moe

AU - Beck-Nielsen, Signe Sparre

AU - Lando, Ane

AU - Greisen, Gorm

AU - Zachariassen, Gitte

N1 - ©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Aim When a new high amino acid parenteral nutrition (PN) solution was introduced to our hospital, a design error led to decreased phosphate levels. This prompted us to examine the effect of three different PN solutions on plasma phosphate, plasma calcium and weight increases on extremely preterm infants. Method This was a retrospective study of 186 infants with a gestational age of <28 weeks during their first month of life. They were divided into three groups based on the PN they received during hospitalisation. Group one received high levels of phosphate and low levels of amino acids. Group two received low levels of phosphate and high levels of amino acids. Group three received high levels of both phosphate and amino acids. Results The lowest plasma phosphate values varied significantly between groups one (1.80 ± 0.46 mmol/L), two (1.05 ± 0.48 mmol/L) and three (1.40 ± 0.37 mmol/L) (p < 0.001), but no significant difference in weight increase was seen (p = 0.497). Conclusion The phosphate content of the PN influenced plasma phosphate and plasma calcium levels, but increasing the levels of both phosphate and amino acids did not improve weight gain during the first month of life.

AB - Aim When a new high amino acid parenteral nutrition (PN) solution was introduced to our hospital, a design error led to decreased phosphate levels. This prompted us to examine the effect of three different PN solutions on plasma phosphate, plasma calcium and weight increases on extremely preterm infants. Method This was a retrospective study of 186 infants with a gestational age of <28 weeks during their first month of life. They were divided into three groups based on the PN they received during hospitalisation. Group one received high levels of phosphate and low levels of amino acids. Group two received low levels of phosphate and high levels of amino acids. Group three received high levels of both phosphate and amino acids. Results The lowest plasma phosphate values varied significantly between groups one (1.80 ± 0.46 mmol/L), two (1.05 ± 0.48 mmol/L) and three (1.40 ± 0.37 mmol/L) (p < 0.001), but no significant difference in weight increase was seen (p = 0.497). Conclusion The phosphate content of the PN influenced plasma phosphate and plasma calcium levels, but increasing the levels of both phosphate and amino acids did not improve weight gain during the first month of life.

KW - Amino Acids

KW - Calcium

KW - Female

KW - Humans

KW - Infant, Extremely Premature

KW - Infant, Newborn

KW - Infant, Premature, Diseases

KW - Male

KW - Parenteral Nutrition

KW - Parenteral Nutrition Solutions

KW - Phosphates

KW - Retrospective Studies

KW - Weight Gain

U2 - 10.1111/apa.13063

DO - 10.1111/apa.13063

M3 - Journal article

C2 - 26046292

SN - 0803-5253

VL - 104

SP - 894

EP - 899

JO - Acta paediatrica (Oslo, Norway : 1992)

JF - Acta paediatrica (Oslo, Norway : 1992)

IS - 9

ER -