Adiponectin and leptin as first trimester markers for gestational diabetes mellitus: A cohort study

Ida Näslund Thagaard; Lone Krebs; Jens Christian Holm; Theis Lange; Torben Larsen; Michael Christiansen

doi:10.1515/cclm-2017-0427

Adiponectin and leptin as first trimester markers for gestational diabetes mellitus: A cohort study

Ida Näslund Thagaard^*, Lone Krebs, Jens Christian Holm, Theis Lange, Torben Larsen, Michael Christiansen

^*Corresponding author for this work

20 Citations (Scopus)

Abstract

Background:

Gestational diabetes mellitus (GDM) is increasing partly due to the obesity epidemic. Adipocytokines have thus been suggested as first trimester screening markers for GDM. In this study we explore the associations between body mass index (BMI) and serum concentrations of adiponectin, leptin, and the adiponectin/leptin ratio. Furthermore, we investigate whether these markers can improve the ability to screen for GDM in the first trimester.

Methods:

A cohort study in which serum adiponectin and leptin were measured between gestational weeks 6+0 and 14+0 in 2590 pregnant women, categorized into normal weight, moderately obese, or severely obese.

Results:

Lower concentrations of adiponectin were associated with GDM in all BMI groups; the association was more pronounced in BMI<35 kg/m² (p=0.30 for interaction). Leptin was inversely associated with GDM in severely obese (p=0.033), but showed no association in women with BMI<35 kg/m². The adiponectin/leptin ratio was associated with GDM in women with BMI<35 kg/m² but not in severely obese women (p=0.79). In regard to predicting GDM, maternal characteristics combined with adiponectin alone, adiponcetin and leptin, and adiponcetin/leptin ratio had the strongest associations in women with BMI<35 kg/m². These models had a detection rate of 77.3%–80.3% when the false positive rate was fixed at 25%.

Conclusions:

Low adiponectin measured in the first trimester is associated with the development of GDM; higher BMI was associated with lower performance of adiponectin, though this was insignificant. Leptin had an inverse relationship with GDM in severely obese women and did not improve the ability to predict GDM.

Original language	English
Journal	Clinical Chemistry and Laboratory Medicine
Volume	55
Issue number	11
Pages (from-to)	1805-1812
Number of pages	8
ISSN	1434-6621
DOIs	https://doi.org/10.1515/cclm-2017-0427
Publication status	Published - 2017

Keywords

adiponectin
body mass index
first trimester screeing
gestational diabetes mellitus
leptin
obesity
pregnancy trimester

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1515/cclm-2017-0427

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title = "Adiponectin and leptin as first trimester markers for gestational diabetes mellitus: A cohort study",

abstract = "Background:Gestational diabetes mellitus (GDM) is increasing partly due to the obesity epidemic. Adipocytokines have thus been suggested as first trimester screening markers for GDM. In this study we explore the associations between body mass index (BMI) and serum concentrations of adiponectin, leptin, and the adiponectin/leptin ratio. Furthermore, we investigate whether these markers can improve the ability to screen for GDM in the first trimester.Methods:A cohort study in which serum adiponectin and leptin were measured between gestational weeks 6+0 and 14+0 in 2590 pregnant women, categorized into normal weight, moderately obese, or severely obese.Results:Lower concentrations of adiponectin were associated with GDM in all BMI groups; the association was more pronounced in BMI<35 kg/m2 (p=0.30 for interaction). Leptin was inversely associated with GDM in severely obese (p=0.033), but showed no association in women with BMI<35 kg/m2. The adiponectin/leptin ratio was associated with GDM in women with BMI<35 kg/m2 but not in severely obese women (p=0.79). In regard to predicting GDM, maternal characteristics combined with adiponectin alone, adiponcetin and leptin, and adiponcetin/leptin ratio had the strongest associations in women with BMI<35 kg/m2. These models had a detection rate of 77.3%–80.3% when the false positive rate was fixed at 25%.Conclusions:Low adiponectin measured in the first trimester is associated with the development of GDM; higher BMI was associated with lower performance of adiponectin, though this was insignificant. Leptin had an inverse relationship with GDM in severely obese women and did not improve the ability to predict GDM.",

keywords = "adiponectin, body mass index, first trimester screeing, gestational diabetes mellitus, leptin, obesity, pregnancy trimester",

author = "Thagaard, {Ida N{\"a}slund} and Lone Krebs and Holm, {Jens Christian} and Theis Lange and Torben Larsen and Michael Christiansen",

year = "2017",

doi = "10.1515/cclm-2017-0427",

language = "English",

volume = "55",

pages = "1805--1812",

journal = "Clinical Chemistry and Laboratory Medicine",

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TY - JOUR

T1 - Adiponectin and leptin as first trimester markers for gestational diabetes mellitus

T2 - A cohort study

AU - Thagaard, Ida Näslund

AU - Krebs, Lone

AU - Holm, Jens Christian

AU - Lange, Theis

AU - Larsen, Torben

AU - Christiansen, Michael

PY - 2017

Y1 - 2017

N2 - Background:Gestational diabetes mellitus (GDM) is increasing partly due to the obesity epidemic. Adipocytokines have thus been suggested as first trimester screening markers for GDM. In this study we explore the associations between body mass index (BMI) and serum concentrations of adiponectin, leptin, and the adiponectin/leptin ratio. Furthermore, we investigate whether these markers can improve the ability to screen for GDM in the first trimester.Methods:A cohort study in which serum adiponectin and leptin were measured between gestational weeks 6+0 and 14+0 in 2590 pregnant women, categorized into normal weight, moderately obese, or severely obese.Results:Lower concentrations of adiponectin were associated with GDM in all BMI groups; the association was more pronounced in BMI<35 kg/m2 (p=0.30 for interaction). Leptin was inversely associated with GDM in severely obese (p=0.033), but showed no association in women with BMI<35 kg/m2. The adiponectin/leptin ratio was associated with GDM in women with BMI<35 kg/m2 but not in severely obese women (p=0.79). In regard to predicting GDM, maternal characteristics combined with adiponectin alone, adiponcetin and leptin, and adiponcetin/leptin ratio had the strongest associations in women with BMI<35 kg/m2. These models had a detection rate of 77.3%–80.3% when the false positive rate was fixed at 25%.Conclusions:Low adiponectin measured in the first trimester is associated with the development of GDM; higher BMI was associated with lower performance of adiponectin, though this was insignificant. Leptin had an inverse relationship with GDM in severely obese women and did not improve the ability to predict GDM.

AB - Background:Gestational diabetes mellitus (GDM) is increasing partly due to the obesity epidemic. Adipocytokines have thus been suggested as first trimester screening markers for GDM. In this study we explore the associations between body mass index (BMI) and serum concentrations of adiponectin, leptin, and the adiponectin/leptin ratio. Furthermore, we investigate whether these markers can improve the ability to screen for GDM in the first trimester.Methods:A cohort study in which serum adiponectin and leptin were measured between gestational weeks 6+0 and 14+0 in 2590 pregnant women, categorized into normal weight, moderately obese, or severely obese.Results:Lower concentrations of adiponectin were associated with GDM in all BMI groups; the association was more pronounced in BMI<35 kg/m2 (p=0.30 for interaction). Leptin was inversely associated with GDM in severely obese (p=0.033), but showed no association in women with BMI<35 kg/m2. The adiponectin/leptin ratio was associated with GDM in women with BMI<35 kg/m2 but not in severely obese women (p=0.79). In regard to predicting GDM, maternal characteristics combined with adiponectin alone, adiponcetin and leptin, and adiponcetin/leptin ratio had the strongest associations in women with BMI<35 kg/m2. These models had a detection rate of 77.3%–80.3% when the false positive rate was fixed at 25%.Conclusions:Low adiponectin measured in the first trimester is associated with the development of GDM; higher BMI was associated with lower performance of adiponectin, though this was insignificant. Leptin had an inverse relationship with GDM in severely obese women and did not improve the ability to predict GDM.

KW - adiponectin

KW - body mass index

KW - first trimester screeing

KW - gestational diabetes mellitus

KW - leptin

KW - obesity

KW - pregnancy trimester

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DO - 10.1515/cclm-2017-0427

M3 - Journal article

C2 - 28763297

AN - SCOPUS:85031042669

SN - 1434-6621

VL - 55

SP - 1805

EP - 1812

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

IS - 11

ER -

Adiponectin and leptin as first trimester markers for gestational diabetes mellitus: A cohort study

Abstract

Keywords

UN SDGs

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