Adhesion molecules in inflammatory and neoplastic intestinal diseases

TY - JOUR

T1 - Adhesion molecules in inflammatory and neoplastic intestinal diseases

AU - Pedersen, G

AU - Brynskov, J

AU - Nielsen, O H

AU - Bendtzen, K

PY - 1995/9/1

Y1 - 1995/9/1

N2 - Adhesion molecules participate in a broad variety of biological processes, i.e. tumor progression and inflammation, through their involvement in cell-to-cell interactions and immunoinflammatory cell migration. This review describes the basic properties of adhesion molecules with reference to inflammatory bowel disease and colorectal carcinoma. Accumulating data suggest that adhesion molecules could be pathogenetically pertinent to other gastrointestinal disorders such as celiac disease (nontropical sprue) and gastroduodenal ulcer. Future therapeutic approaches in inflammatory and malignant disorders may possibly be development of principles targeting adhesion molecules.

AB - Adhesion molecules participate in a broad variety of biological processes, i.e. tumor progression and inflammation, through their involvement in cell-to-cell interactions and immunoinflammatory cell migration. This review describes the basic properties of adhesion molecules with reference to inflammatory bowel disease and colorectal carcinoma. Accumulating data suggest that adhesion molecules could be pathogenetically pertinent to other gastrointestinal disorders such as celiac disease (nontropical sprue) and gastroduodenal ulcer. Future therapeutic approaches in inflammatory and malignant disorders may possibly be development of principles targeting adhesion molecules.

KW - Cell Adhesion Molecules/physiology

KW - Colorectal Neoplasms/physiopathology

KW - Humans

KW - Inflammation/physiopathology

KW - Inflammatory Bowel Diseases/physiopathology

U2 - 10.1159/000171512

DO - 10.1159/000171512

M3 - Review

C2 - 8542667

SN - 0257-2753

VL - 13

SP - 322

EP - 336

JO - Digestive Diseases

JF - Digestive Diseases

IS - 5

ER -