Added value of IP-10 as a read-out of Mycobacterium tuberculosis: Specific immunity in young children

TY - JOUR

T1 - Added value of IP-10 as a read-out of Mycobacterium tuberculosis

T2 - Specific immunity in young children

AU - Jenum, Synne

AU - Dhanasekaran, Sivmakumaran

AU - Ritz, Christian

AU - Macaden, Ragini

AU - Doherty, T Mark

AU - Grewal, Harleen M.S.

AU - TB Trials Study Group

N1 - CURIS 2016 NEXS 329

PY - 2016/11/28

Y1 - 2016/11/28

N2 - We have explored the added value of interferon-γ (IFNγ)-inducible protein 10 as a read-out of Mycobacterium tuberculosis-specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays.

AB - We have explored the added value of interferon-γ (IFNγ)-inducible protein 10 as a read-out of Mycobacterium tuberculosis-specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays.

KW - Faculty of Science

KW - Tuberculosis

KW - Child

KW - Tuberculin skin test

KW - Interferon-gamma release assay

KW - Cytokines

KW - Chemokines

U2 - 10.1097/INF.0000000000001328

DO - 10.1097/INF.0000000000001328

M3 - Journal article

C2 - 27642776

SN - 0891-3668

VL - 35

SP - 1336

EP - 1338

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 12

ER -