Acute P. falciparum malaria induces a loss of CD28- T IFN-¿ producing cells

Kåre Kemp; Bartholomew D Akanmori; Jørgen A L Kurtzhals; Victoria Adabayeri; Bamenla Q Goka; Lars Hviid

Acute P. falciparum malaria induces a loss of CD28^- T IFN-¿ producing cells

Kåre Kemp, Bartholomew D Akanmori, Jørgen A L Kurtzhals, Victoria Adabayeri, Bamenla Q Goka, Lars Hviid

4 Citations (Scopus)

Abstract

P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-gamma and IL-4 by CD28-and CD28+T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-gamma producing CD28-T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.

Original language	English
Journal	Parasite Immunology
Volume	24
Issue number	11-12
Pages (from-to)	545-8
Number of pages	3
ISSN	0141-9838
Publication status	Published - 2002

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@article{1529ebc0a19911dd95e9000ea68e967b,

title = "Acute P. falciparum malaria induces a loss of CD28- T IFN-¿ producing cells",

abstract = "P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-gamma and IL-4 by CD28-and CD28+T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-gamma producing CD28-T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.",

author = "K{\aa}re Kemp and Akanmori, {Bartholomew D} and Kurtzhals, {J{\o}rgen A L} and Victoria Adabayeri and Goka, {Bamenla Q} and Lars Hviid",

note = "Keywords: Acute Disease; Animals; Antigens, CD28; Antigens, CD95; Apoptosis; Genes, bcl-2; Humans; Interferon Type II; Interleukin-4; Malaria, Falciparum; Plasmodium falciparum; T-Lymphocyte Subsets; T-Lymphocytes",

year = "2002",

language = "English",

volume = "24",

pages = "545--8",

journal = "Parasite Immunology",

issn = "0141-9838",

publisher = "Wiley-Blackwell",

number = "11-12",

}

TY - JOUR

T1 - Acute P. falciparum malaria induces a loss of CD28- T IFN-¿ producing cells

AU - Kemp, Kåre

AU - Akanmori, Bartholomew D

AU - Kurtzhals, Jørgen A L

AU - Adabayeri, Victoria

AU - Goka, Bamenla Q

AU - Hviid, Lars

N1 - Keywords: Acute Disease; Animals; Antigens, CD28; Antigens, CD95; Apoptosis; Genes, bcl-2; Humans; Interferon Type II; Interleukin-4; Malaria, Falciparum; Plasmodium falciparum; T-Lymphocyte Subsets; T-Lymphocytes

PY - 2002

Y1 - 2002

N2 - P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-gamma and IL-4 by CD28-and CD28+T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-gamma producing CD28-T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.

AB - P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-gamma and IL-4 by CD28-and CD28+T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-gamma producing CD28-T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.

M3 - Journal article

C2 - 12694605

SN - 0141-9838

VL - 24

SP - 545

EP - 548

JO - Parasite Immunology

JF - Parasite Immunology

IS - 11-12

ER -

Acute P. falciparum malaria induces a loss of CD28- T IFN-¿ producing cells

Abstract

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Acute P. falciparum malaria induces a loss of CD28^- T IFN-¿ producing cells