Activation of the hippocampal complex during tactile maze solving in congenitally blind subjects

TY - JOUR

T1 - Activation of the hippocampal complex during tactile maze solving in congenitally blind subjects

AU - Gagnon, Léa

AU - Schneider, Fabien C

AU - Siebner, Hartwig R

AU - Paulson, Olaf B

AU - Kupers, Ron

AU - Ptito, Maurice

N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.

PY - 2012/6

Y1 - 2012/6

N2 - Despite their lack of vision, congenitally blind subjects are able to build and manipulate cognitive maps for spatial navigation. It is assumed that they thereby rely more heavily on echolocation, proprioceptive signals and environmental cues such as ambient temperature and audition to compensate for their lack of vision. Little is known, however, about the neural mechanisms underlying spatial navigation in blind individuals in settings where these cues are absent. We therefore measured behavioural performance and blood oxygenation-level dependant (BOLD) responses using functional magnetic resonance imaging (fMRI) in congenitally blind and blindfolded sighted participants while they navigated through a tactile multiple T-maze. Both groups learned the maze task at a similar pace. In blind participants, tactile maze navigation was associated with increased BOLD responses in the right hippocampus and parahippocampus, occipital cortex and fusiform gyrus. Blindfolded sighted controls did not show increased BOLD responses in these areas; instead they activated the caudate nucleus and thalamus. Both groups activated the precuneus during tactile maze navigation. We conclude that cross-modal plastic processes allow for the recruitment of the hippocampal complex and visual cortex in congenital blindness.

AB - Despite their lack of vision, congenitally blind subjects are able to build and manipulate cognitive maps for spatial navigation. It is assumed that they thereby rely more heavily on echolocation, proprioceptive signals and environmental cues such as ambient temperature and audition to compensate for their lack of vision. Little is known, however, about the neural mechanisms underlying spatial navigation in blind individuals in settings where these cues are absent. We therefore measured behavioural performance and blood oxygenation-level dependant (BOLD) responses using functional magnetic resonance imaging (fMRI) in congenitally blind and blindfolded sighted participants while they navigated through a tactile multiple T-maze. Both groups learned the maze task at a similar pace. In blind participants, tactile maze navigation was associated with increased BOLD responses in the right hippocampus and parahippocampus, occipital cortex and fusiform gyrus. Blindfolded sighted controls did not show increased BOLD responses in these areas; instead they activated the caudate nucleus and thalamus. Both groups activated the precuneus during tactile maze navigation. We conclude that cross-modal plastic processes allow for the recruitment of the hippocampal complex and visual cortex in congenital blindness.

KW - Adult

KW - Analysis of Variance

KW - Blindness

KW - Brain Mapping

KW - Female

KW - Hippocampus

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Maze Learning

KW - Middle Aged

KW - Oxygen

KW - Problem Solving

KW - Time Factors

KW - Touch

KW - Young Adult

U2 - 10.1016/j.neuropsychologia.2012.03.022

DO - 10.1016/j.neuropsychologia.2012.03.022

M3 - Journal article

C2 - 22483742

SN - 0028-3932

VL - 50

SP - 1663

EP - 1671

JO - Neuropsychologia

JF - Neuropsychologia

IS - 7

ER -