Activation of rice nicotianamine synthase 2 (OsNAS2) enhances iron availability for biofortification

TY - JOUR

T1 - Activation of rice nicotianamine synthase 2 (OsNAS2) enhances iron availability for biofortification

AU - Lee, Sichul

AU - Kim, You-Sun

AU - Jeon, Un Sil

AU - Kim, Yoon-Keun

AU - Schjørring, Jan Kofod

AU - An, Gynheung

PY - 2012/3

Y1 - 2012/3

N2 - Because micronutrients in human diets ultimately come from plant sources, malnutrition of essential minerals is a significant public health concern. By increasing the expression of nicotianamine synthase (NAS), we fortified the level of bioavailable iron in rice seeds. Activation of iron deficiency-inducible OsNAS2 resulted in a rise in Fe content (3.0-fold) in mature seeds. Its ectopic expression also increased that content. Enhanced expression led to higher tolerance of Fe deficiency and better growth under elevated pH. Mice fed with OsNAS2-D1 seeds recovered more rapidly from anemia, indicating that bioavailable Fe contents were improved by this increase in OsNAS2 expression.

AB - Because micronutrients in human diets ultimately come from plant sources, malnutrition of essential minerals is a significant public health concern. By increasing the expression of nicotianamine synthase (NAS), we fortified the level of bioavailable iron in rice seeds. Activation of iron deficiency-inducible OsNAS2 resulted in a rise in Fe content (3.0-fold) in mature seeds. Its ectopic expression also increased that content. Enhanced expression led to higher tolerance of Fe deficiency and better growth under elevated pH. Mice fed with OsNAS2-D1 seeds recovered more rapidly from anemia, indicating that bioavailable Fe contents were improved by this increase in OsNAS2 expression.

U2 - 10.1007/s10059-012-2231-3

DO - 10.1007/s10059-012-2231-3

M3 - Journal article

C2 - 22228185

SN - 1016-8478

VL - 33

SP - 269

EP - 275

JO - Molecules and Cells

JF - Molecules and Cells

IS - 3

ER -