Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea)

Kathrine B Christensen; Rasmus K Petersen; Sidsel Petersen; Karsten Kristiansen; Lars P Christensen

doi:10.1021/np900003a

Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea)

Kathrine B Christensen, Rasmus K Petersen, Sidsel Petersen, Karsten Kristiansen, Lars P Christensen

Department of Biology

28 Citations (Scopus)

Abstract

Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPARgamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was new, and three fatty acids that all activated PPARgamma. The new alkamide hexadeca-2E,9Z,12Z,14E-tetraenoic acid isobutylamide (5) was identified by analysis of spectroscopic data and found to activate PPARgamma with no concurrent stimulation of adipocyte differentiation. Compound 5 was further shown to increase insulin-stimulated glucose uptake. The data suggest that flowers of E. purpurea contain compounds with potential to manage insulin resistance and type 2 diabetes.

Original language	English
Journal	Journal of Natural Products
Volume	72
Issue number	5
Pages (from-to)	933–937
ISSN	0163-3864
DOIs	https://doi.org/10.1021/np900003a
Publication status	Published - 2009

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title = "Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea)",

abstract = "Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPARgamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was new, and three fatty acids that all activated PPARgamma. The new alkamide hexadeca-2E,9Z,12Z,14E-tetraenoic acid isobutylamide (5) was identified by analysis of spectroscopic data and found to activate PPARgamma with no concurrent stimulation of adipocyte differentiation. Compound 5 was further shown to increase insulin-stimulated glucose uptake. The data suggest that flowers of E. purpurea contain compounds with potential to manage insulin resistance and type 2 diabetes.",

author = "Christensen, {Kathrine B} and Petersen, {Rasmus K} and Sidsel Petersen and Karsten Kristiansen and Christensen, {Lars P}",

year = "2009",

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pages = "933–937",

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T1 - Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea)

AU - Christensen, Kathrine B

AU - Petersen, Rasmus K

AU - Petersen, Sidsel

AU - Kristiansen, Karsten

AU - Christensen, Lars P

PY - 2009

Y1 - 2009

N2 - Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPARgamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was new, and three fatty acids that all activated PPARgamma. The new alkamide hexadeca-2E,9Z,12Z,14E-tetraenoic acid isobutylamide (5) was identified by analysis of spectroscopic data and found to activate PPARgamma with no concurrent stimulation of adipocyte differentiation. Compound 5 was further shown to increase insulin-stimulated glucose uptake. The data suggest that flowers of E. purpurea contain compounds with potential to manage insulin resistance and type 2 diabetes.

AB - Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPARgamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was new, and three fatty acids that all activated PPARgamma. The new alkamide hexadeca-2E,9Z,12Z,14E-tetraenoic acid isobutylamide (5) was identified by analysis of spectroscopic data and found to activate PPARgamma with no concurrent stimulation of adipocyte differentiation. Compound 5 was further shown to increase insulin-stimulated glucose uptake. The data suggest that flowers of E. purpurea contain compounds with potential to manage insulin resistance and type 2 diabetes.

U2 - 10.1021/np900003a

DO - 10.1021/np900003a

M3 - Journal article

C2 - 19374389

SN - 0163-3864

VL - 72

SP - 933

EP - 937

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Activation of PPARgamma by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea)

Abstract

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