Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia

I. H. Lambert; S. F. Pedersen; K. A. Poulsen

doi:10.1111/j.1748-1716.2006.01557.x

Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia

I. H. Lambert, S. F. Pedersen, K. A. Poulsen

74 Citations (Scopus)

Abstract

Phospholipase A₂ (PLA₂) activity is increased in mammalian cells in response to numerous stimuli such as osmotic challenge, oxidative stress and exposure to allergens. The increased PLA₂ activity is seen as an increased release of free, polyunsaturated fatty acids, e.g. arachidonic acid and membrane-bound lysophospholipids. Even though arachidonic acid acts as a second messenger in its own most mammalian cells seem to rely on oxidation of the fatty acid into highly potent second messengers via, e.g. cytochrome P450, the cyclo-oxygenase, or the lipoxygenase systems for downstream signalling. Here, we review data that illustrates that stress-induced PLA₂ activity involves various PLA₂ subtypes and that the PLA₂ in question is determined by the cell type and the physiological stress condition.

Original language	English
Journal	Acta Physiologica (Print Edition)
Volume	187
Issue number	1-2
Pages (from-to)	75-85
ISSN	1748-1708
DOIs	https://doi.org/10.1111/j.1748-1716.2006.01557.x
Publication status	Published - 2006

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title = "Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia",

abstract = "Phospholipase A2 (PLA2) activity is increased in mammalian cells in response to numerous stimuli such as osmotic challenge, oxidative stress and exposure to allergens. The increased PLA2 activity is seen as an increased release of free, polyunsaturated fatty acids, e.g. arachidonic acid and membrane-bound lysophospholipids. Even though arachidonic acid acts as a second messenger in its own most mammalian cells seem to rely on oxidation of the fatty acid into highly potent second messengers via, e.g. cytochrome P450, the cyclo-oxygenase, or the lipoxygenase systems for downstream signalling. Here, we review data that illustrates that stress-induced PLA2 activity involves various PLA2 subtypes and that the PLA2 in question is determined by the cell type and the physiological stress condition.",

author = "Lambert, {I. H.} and Pedersen, {S. F.} and Poulsen, {K. A.}",

note = "KEYWORDS arachidonic acid • F-actin • Ca2+-independent phospholipase A2 • ischaemia • organic osmolytes • phospholipase A2 • reactive oxygen species",

year = "2006",

doi = "10.1111/j.1748-1716.2006.01557.x",

language = "English",

volume = "187",

pages = "75--85",

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TY - JOUR

T1 - Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia

AU - Lambert, I. H.

AU - Pedersen, S. F.

AU - Poulsen, K. A.

N1 - KEYWORDS arachidonic acid • F-actin • Ca2+-independent phospholipase A2 • ischaemia • organic osmolytes • phospholipase A2 • reactive oxygen species

PY - 2006

Y1 - 2006

N2 - Phospholipase A2 (PLA2) activity is increased in mammalian cells in response to numerous stimuli such as osmotic challenge, oxidative stress and exposure to allergens. The increased PLA2 activity is seen as an increased release of free, polyunsaturated fatty acids, e.g. arachidonic acid and membrane-bound lysophospholipids. Even though arachidonic acid acts as a second messenger in its own most mammalian cells seem to rely on oxidation of the fatty acid into highly potent second messengers via, e.g. cytochrome P450, the cyclo-oxygenase, or the lipoxygenase systems for downstream signalling. Here, we review data that illustrates that stress-induced PLA2 activity involves various PLA2 subtypes and that the PLA2 in question is determined by the cell type and the physiological stress condition.

AB - Phospholipase A2 (PLA2) activity is increased in mammalian cells in response to numerous stimuli such as osmotic challenge, oxidative stress and exposure to allergens. The increased PLA2 activity is seen as an increased release of free, polyunsaturated fatty acids, e.g. arachidonic acid and membrane-bound lysophospholipids. Even though arachidonic acid acts as a second messenger in its own most mammalian cells seem to rely on oxidation of the fatty acid into highly potent second messengers via, e.g. cytochrome P450, the cyclo-oxygenase, or the lipoxygenase systems for downstream signalling. Here, we review data that illustrates that stress-induced PLA2 activity involves various PLA2 subtypes and that the PLA2 in question is determined by the cell type and the physiological stress condition.

U2 - 10.1111/j.1748-1716.2006.01557.x

DO - 10.1111/j.1748-1716.2006.01557.x

M3 - Journal article

SN - 1748-1708

VL - 187

SP - 75

EP - 85

JO - Acta Physiologica

JF - Acta Physiologica

IS - 1-2

ER -

Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia

Abstract

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