Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors

Célia Dechavanne; Ibrahim Sadissou; Aziz Bouraima; Claude Ahouangninou; Roukiyath Amoussa; Jacqueline Milet; Kabirou Moutairou; Achille Massougbodji; Michael Theisen; Edmond J Remarque; David Courtin; Gregory Nuel; Florence Migot-Nabias; André Garcia

doi:10.1038/srep33961

Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors

Célia Dechavanne, Ibrahim Sadissou, Aziz Bouraima, Claude Ahouangninou, Roukiyath Amoussa, Jacqueline Milet, Kabirou Moutairou, Achille Massougbodji, Michael Theisen, Edmond J Remarque, David Courtin, Gregory Nuel, Florence Migot-Nabias, André Garcia

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Abstract

To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas.Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6-to18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6-to18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.

Original language	English
Article number	33961
Journal	Scientific Reports
Volume	6
Number of pages	9
ISSN	2045-2322
DOIs	https://doi.org/10.1038/srep33961
Publication status	Published - 27 Sept 2016

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Dechavanne, C., Sadissou, I., Bouraima, A., Ahouangninou, C., Amoussa, R., Milet, J., Moutairou, K., Massougbodji, A., Theisen, M., Remarque, E. J., Courtin, D., Nuel, G., Migot-Nabias, F., & Garcia, A. (2016). Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors. Scientific Reports, 6, [33961]. https://doi.org/10.1038/srep33961

Dechavanne, C, Sadissou, I, Bouraima, A, Ahouangninou, C, Amoussa, R, Milet, J, Moutairou, K, Massougbodji, A, Theisen, M, Remarque, EJ, Courtin, D, Nuel, G, Migot-Nabias, F & Garcia, A 2016, 'Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors', Scientific Reports, vol. 6, 33961. https://doi.org/10.1038/srep33961

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title = "Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors",

abstract = "To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas.Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6-to18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6-to18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.",

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T2 - impact of clinical, environmental and host factors

AU - Dechavanne, Célia

AU - Sadissou, Ibrahim

AU - Bouraima, Aziz

AU - Ahouangninou, Claude

AU - Amoussa, Roukiyath

AU - Milet, Jacqueline

AU - Moutairou, Kabirou

AU - Massougbodji, Achille

AU - Theisen, Michael

AU - Remarque, Edmond J

AU - Courtin, David

AU - Nuel, Gregory

AU - Migot-Nabias, Florence

AU - Garcia, André

PY - 2016/9/27

Y1 - 2016/9/27

N2 - To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas.Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6-to18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6-to18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.

AB - To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas.Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6-to18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6-to18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.

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DO - 10.1038/srep33961

M3 - Journal article

C2 - 27670685

SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 33961

ER -

Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors

Abstract

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