Abnormal echocardiography in patients with type 2 diabetes and relation to symptoms and clinical characteristics

Peter Godsk Jørgensen; Magnus Thorsten Jensen; Rasmus Mogelvang; Bernt Johan von Scholten; Jan Bech; Thomas Fritz Hansen; Søren Galatius; Tor Biering-Sørensen; Henrik Ullits Andersen; Tina Vilsbøll Lauritsen; Peter Rossing; Jan Skov Jensen

doi:10.1177/1479164116645583

Abnormal echocardiography in patients with type 2 diabetes and relation to symptoms and clinical characteristics

Peter Godsk Jørgensen, Magnus Thorsten Jensen, Rasmus Mogelvang, Bernt Johan von Scholten, Jan Bech, Thomas Fritz Hansen, Søren Galatius, Tor Biering-Sørensen, Henrik Ullits Andersen, Tina Vilsbøll Lauritsen, Peter Rossing, Jan Skov Jensen

Department of Clinical Medicine

29 Citations (Scopus)

Abstract

Objectives: We aimed to determine the prevalence of echocardiographic abnormalities and their relation to clinical characteristics and cardiac symptoms in a large, contemporary cohort of patients with type 2 diabetes. Results: A total of 1030 patients with type 2 diabetes participated. Echocardiographic abnormalities were present in 513 (49.8%) patients, mainly driven by a high prevalence of diastolic dysfunction 178 (19.4%), left ventricular hypertrophy 213 (21.0%) and left atrial enlargement, 200 (19.6%). The prevalence increased markedly with age from 31.1% in the youngest group (<55 years) to 73.9% in the oldest group (>75 years) (p < 0.001) and was equally distributed among the sexes (p = 0.76). In univariate analyses, electrocardiographic abnormalities, age, body mass index, known coronary heart disease, hypertension, albuminuria, diabetes duration and creatinine were associated with abnormal echocardiography along with dyspnoea and characteristic chest pain (p < 0.05 for all). Neither of the cardiac symptoms nor clinical characteristics had sufficient sensitivity and specificity to accurately identify patients with abnormal echocardiography. Conclusion: Echocardiographic abnormalities are very common in outpatients with type 2 diabetes, but neither cardiac symptoms nor clinical characteristics are effective to identify patients with echocardiographic abnormalities.

Original language	English
Journal	Diabetes and Vascular Disease Research
Volume	13
Issue number	5
Pages (from-to)	321-330
Number of pages	10
ISSN	1479-1641
DOIs	https://doi.org/10.1177/1479164116645583
Publication status	Published - 1 Sept 2016

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Jørgensen, P. G., Jensen, M. T., Mogelvang, R., von Scholten, B. J., Bech, J., Hansen, T. F., Galatius, S., Biering-Sørensen, T., Andersen, H. U., Lauritsen, T. V., Rossing, P., & Jensen, J. S. (2016). Abnormal echocardiography in patients with type 2 diabetes and relation to symptoms and clinical characteristics. Diabetes and Vascular Disease Research, 13(5), 321-330. https://doi.org/10.1177/1479164116645583

Jørgensen, PG, Jensen, MT, Mogelvang, R, von Scholten, BJ, Bech, J, Hansen, TF, Galatius, S, Biering-Sørensen, T, Andersen, HU, Lauritsen, TV , Rossing, P & Jensen, JS 2016, 'Abnormal echocardiography in patients with type 2 diabetes and relation to symptoms and clinical characteristics', Diabetes and Vascular Disease Research, vol. 13, no. 5, pp. 321-330. https://doi.org/10.1177/1479164116645583

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AU - Bech, Jan

AU - Hansen, Thomas Fritz

AU - Galatius, Søren

AU - Biering-Sørensen, Tor

AU - Andersen, Henrik Ullits

AU - Lauritsen, Tina Vilsbøll

AU - Rossing, Peter

AU - Jensen, Jan Skov

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N2 - Objectives: We aimed to determine the prevalence of echocardiographic abnormalities and their relation to clinical characteristics and cardiac symptoms in a large, contemporary cohort of patients with type 2 diabetes. Results: A total of 1030 patients with type 2 diabetes participated. Echocardiographic abnormalities were present in 513 (49.8%) patients, mainly driven by a high prevalence of diastolic dysfunction 178 (19.4%), left ventricular hypertrophy 213 (21.0%) and left atrial enlargement, 200 (19.6%). The prevalence increased markedly with age from 31.1% in the youngest group (<55 years) to 73.9% in the oldest group (>75 years) (p < 0.001) and was equally distributed among the sexes (p = 0.76). In univariate analyses, electrocardiographic abnormalities, age, body mass index, known coronary heart disease, hypertension, albuminuria, diabetes duration and creatinine were associated with abnormal echocardiography along with dyspnoea and characteristic chest pain (p < 0.05 for all). Neither of the cardiac symptoms nor clinical characteristics had sufficient sensitivity and specificity to accurately identify patients with abnormal echocardiography. Conclusion: Echocardiographic abnormalities are very common in outpatients with type 2 diabetes, but neither cardiac symptoms nor clinical characteristics are effective to identify patients with echocardiographic abnormalities.

AB - Objectives: We aimed to determine the prevalence of echocardiographic abnormalities and their relation to clinical characteristics and cardiac symptoms in a large, contemporary cohort of patients with type 2 diabetes. Results: A total of 1030 patients with type 2 diabetes participated. Echocardiographic abnormalities were present in 513 (49.8%) patients, mainly driven by a high prevalence of diastolic dysfunction 178 (19.4%), left ventricular hypertrophy 213 (21.0%) and left atrial enlargement, 200 (19.6%). The prevalence increased markedly with age from 31.1% in the youngest group (<55 years) to 73.9% in the oldest group (>75 years) (p < 0.001) and was equally distributed among the sexes (p = 0.76). In univariate analyses, electrocardiographic abnormalities, age, body mass index, known coronary heart disease, hypertension, albuminuria, diabetes duration and creatinine were associated with abnormal echocardiography along with dyspnoea and characteristic chest pain (p < 0.05 for all). Neither of the cardiac symptoms nor clinical characteristics had sufficient sensitivity and specificity to accurately identify patients with abnormal echocardiography. Conclusion: Echocardiographic abnormalities are very common in outpatients with type 2 diabetes, but neither cardiac symptoms nor clinical characteristics are effective to identify patients with echocardiographic abnormalities.

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Abnormal echocardiography in patients with type 2 diabetes and relation to symptoms and clinical characteristics

Abstract

Keywords

UN SDGs

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