Abnormal brain processing of pain in migraine without aura: a high-density EEG brain mapping study

L Buchgreitz; L L Egsgaard; R Jensen; L Arendt-Nielsen; L Bendtsen; L Buchgreitz; Line Lindhardt Egsgaard; Rigmor Højland Jensen; L Arendt-Nielsen; L Bendtsen

doi:10.1111/j.1468-2982.2009.01922.x

Abnormal brain processing of pain in migraine without aura: a high-density EEG brain mapping study

L Buchgreitz, L L Egsgaard, R Jensen, L Arendt-Nielsen, L Bendtsen, L Buchgreitz, Line Lindhardt Egsgaard, Rigmor Højland Jensen, L Arendt-Nielsen, L Bendtsen

8 Citations (Scopus)

Abstract

In the present study we used high-density EEG brain mapping to investigate spatio-temporal aspects of brain activity in response to experimentally induced muscle pain in 17 patients with migraine without aura and 15 healthy controls. Painful electrical stimuli were applied to the trapezius muscle and somatosensory-evoked potentials were recorded with 128-channel EEG with and without concurrent induced tonic neck/shoulder muscle pain. At baseline, the calculated P300 dipole for single stimuli was localized in the cingulate cortex. In patients, but not in controls, the dipole changed position from baseline to the tonic muscle pain condition (z = 29mm vs. z= -13 mm, P<0.001) and from baseline to the post-tonic muscle pain condition (z = 29 mm vs. z = -9 mm, P < 0.001). This may be the first evidence that the supraspinal processing of muscle pain is abnormal in patients with migraine without aura.

Original language	English
Journal	Cephalalgia
Volume	30
Issue number	2
Pages (from-to)	191-99
Number of pages	9
ISSN	0333-1024
DOIs	https://doi.org/10.1111/j.1468-2982.2009.01922.x
Publication status	Published - Feb 2010

Access to Document

10.1111/j.1468-2982.2009.01922.x

Cite this

@article{a347b6e632c24cd094647437d65499e3,

title = "Abnormal brain processing of pain in migraine without aura: a high-density EEG brain mapping study",

abstract = "In the present study we used high-density EEG brain mapping to investigate spatio-temporal aspects of brain activity in response to experimentally induced muscle pain in 17 patients with migraine without aura and 15 healthy controls. Painful electrical stimuli were applied to the trapezius muscle and somatosensory-evoked potentials were recorded with 128-channel EEG with and without concurrent induced tonic neck/shoulder muscle pain. At baseline, the calculated P300 dipole for single stimuli was localized in the cingulate cortex. In patients, but not in controls, the dipole changed position from baseline to the tonic muscle pain condition (z = 29mm vs. z= -13 mm, P<0.001) and from baseline to the post-tonic muscle pain condition (z = 29 mm vs. z = -9 mm, P < 0.001). This may be the first evidence that the supraspinal processing of muscle pain is abnormal in patients with migraine without aura.",

author = "L Buchgreitz and Egsgaard, {L L} and R Jensen and L Arendt-Nielsen and L Bendtsen and L Buchgreitz and Egsgaard, {Line Lindhardt} and Jensen, {Rigmor H{\o}jland} and L Arendt-Nielsen and L Bendtsen",

year = "2010",

month = feb,

doi = "10.1111/j.1468-2982.2009.01922.x",

language = "English",

volume = "30",

pages = "191--99",

journal = "Cephalalgia, Supplement",

issn = "0800-1952",

publisher = "SAGE Publications",

number = "2",

}

TY - JOUR

T1 - Abnormal brain processing of pain in migraine without aura: a high-density EEG brain mapping study

AU - Buchgreitz, L

AU - Egsgaard, L L

AU - Jensen, R

AU - Arendt-Nielsen, L

AU - Bendtsen, L

AU - Buchgreitz, L

AU - Egsgaard, Line Lindhardt

AU - Jensen, Rigmor Højland

AU - Arendt-Nielsen, L

AU - Bendtsen, L

PY - 2010/2

Y1 - 2010/2

N2 - In the present study we used high-density EEG brain mapping to investigate spatio-temporal aspects of brain activity in response to experimentally induced muscle pain in 17 patients with migraine without aura and 15 healthy controls. Painful electrical stimuli were applied to the trapezius muscle and somatosensory-evoked potentials were recorded with 128-channel EEG with and without concurrent induced tonic neck/shoulder muscle pain. At baseline, the calculated P300 dipole for single stimuli was localized in the cingulate cortex. In patients, but not in controls, the dipole changed position from baseline to the tonic muscle pain condition (z = 29mm vs. z= -13 mm, P<0.001) and from baseline to the post-tonic muscle pain condition (z = 29 mm vs. z = -9 mm, P < 0.001). This may be the first evidence that the supraspinal processing of muscle pain is abnormal in patients with migraine without aura.

AB - In the present study we used high-density EEG brain mapping to investigate spatio-temporal aspects of brain activity in response to experimentally induced muscle pain in 17 patients with migraine without aura and 15 healthy controls. Painful electrical stimuli were applied to the trapezius muscle and somatosensory-evoked potentials were recorded with 128-channel EEG with and without concurrent induced tonic neck/shoulder muscle pain. At baseline, the calculated P300 dipole for single stimuli was localized in the cingulate cortex. In patients, but not in controls, the dipole changed position from baseline to the tonic muscle pain condition (z = 29mm vs. z= -13 mm, P<0.001) and from baseline to the post-tonic muscle pain condition (z = 29 mm vs. z = -9 mm, P < 0.001). This may be the first evidence that the supraspinal processing of muscle pain is abnormal in patients with migraine without aura.

U2 - 10.1111/j.1468-2982.2009.01922.x

DO - 10.1111/j.1468-2982.2009.01922.x

M3 - Journal article

C2 - 19614704

SN - 0800-1952

VL - 30

SP - 191

EP - 199

JO - Cephalalgia, Supplement

JF - Cephalalgia, Supplement

IS - 2

ER -

Abnormal brain processing of pain in migraine without aura: a high-density EEG brain mapping study

Abstract

Access to Document

Fingerprint

Cite this