Abc1: a new ABC transporter from the fission yeast Schizosaccharomyces pombe

P U Christensen; K Davis; O Nielsen; William John Davey; Olaf Nielsen

Abc1: a new ABC transporter from the fission yeast Schizosaccharomyces pombe

P U Christensen, K Davis, O Nielsen, William John Davey, Olaf Nielsen

Functional Genomics

10 Citations (Scopus)

Abstract

We have isolated the abc1 gene from the fission yeast Schizosaccharomyces pombe. Sequence analysis suggests that the Abc1 protein is a member of the ABC superfamily of transporters and is composed of two structurally homologous halves, each consisting of a hydrophobic region of six transmembrane domains and a hydrophilic region containing one ATP-binding site. The abc1 gene appears to be expressed under all growth conditions but gene disruption experiments indicate that it is not essential for growth. The sequence of the abc1 gene has been deposited in the EMBL data library under the Accession Number Y09354.

Original language	English
Journal	F E M S Microbiology Letters
Volume	147
Issue number	1
Pages (from-to)	97-102
Number of pages	6
ISSN	0378-1097
Publication status	Published - 1 Feb 1997

Keywords

ATP-Binding Cassette Transporters
DNA, Fungal
Fungal Proteins
Genes, Fungal
Molecular Sequence Data
Mutagenesis
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Sequence Analysis, DNA
Sequence Homology, Amino Acid

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title = "Abc1: a new ABC transporter from the fission yeast Schizosaccharomyces pombe",

abstract = "We have isolated the abc1 gene from the fission yeast Schizosaccharomyces pombe. Sequence analysis suggests that the Abc1 protein is a member of the ABC superfamily of transporters and is composed of two structurally homologous halves, each consisting of a hydrophobic region of six transmembrane domains and a hydrophilic region containing one ATP-binding site. The abc1 gene appears to be expressed under all growth conditions but gene disruption experiments indicate that it is not essential for growth. The sequence of the abc1 gene has been deposited in the EMBL data library under the Accession Number Y09354.",

keywords = "ATP-Binding Cassette Transporters, DNA, Fungal, Fungal Proteins, Genes, Fungal, Molecular Sequence Data, Mutagenesis, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Sequence Analysis, DNA, Sequence Homology, Amino Acid",

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T1 - Abc1: a new ABC transporter from the fission yeast Schizosaccharomyces pombe

AU - Christensen, P U

AU - Davis, K

AU - Nielsen, O

AU - Davey, William John

AU - Nielsen, Olaf

PY - 1997/2/1

Y1 - 1997/2/1

N2 - We have isolated the abc1 gene from the fission yeast Schizosaccharomyces pombe. Sequence analysis suggests that the Abc1 protein is a member of the ABC superfamily of transporters and is composed of two structurally homologous halves, each consisting of a hydrophobic region of six transmembrane domains and a hydrophilic region containing one ATP-binding site. The abc1 gene appears to be expressed under all growth conditions but gene disruption experiments indicate that it is not essential for growth. The sequence of the abc1 gene has been deposited in the EMBL data library under the Accession Number Y09354.

AB - We have isolated the abc1 gene from the fission yeast Schizosaccharomyces pombe. Sequence analysis suggests that the Abc1 protein is a member of the ABC superfamily of transporters and is composed of two structurally homologous halves, each consisting of a hydrophobic region of six transmembrane domains and a hydrophilic region containing one ATP-binding site. The abc1 gene appears to be expressed under all growth conditions but gene disruption experiments indicate that it is not essential for growth. The sequence of the abc1 gene has been deposited in the EMBL data library under the Accession Number Y09354.

KW - ATP-Binding Cassette Transporters

KW - DNA, Fungal

KW - Fungal Proteins

KW - Genes, Fungal

KW - Molecular Sequence Data

KW - Mutagenesis

KW - Schizosaccharomyces

KW - Schizosaccharomyces pombe Proteins

KW - Sequence Analysis, DNA

KW - Sequence Homology, Amino Acid

M3 - Journal article

C2 - 9037770

SN - 0378-1097

VL - 147

SP - 97

EP - 102

JO - F E M S Microbiology Letters

JF - F E M S Microbiology Letters

IS - 1

ER -

Abc1: a new ABC transporter from the fission yeast Schizosaccharomyces pombe

Abstract

Keywords

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