A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria fishing community is required for association with highly prevalent organ related morbidity

Edridah M. Tukahebwa; Pascal Magnussen; Henry Madsen; Narcis B. Kabatereine; Fred Nuwaha; Shona Wilson; Birgitte J Vennervald

doi:10.1371/journal.pntd.0002268

A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria fishing community is required for association with highly prevalent organ related morbidity

Edridah M. Tukahebwa, Pascal Magnussen, Henry Madsen, Narcis B. Kabatereine, Fred Nuwaha, Shona Wilson, Birgitte J Vennervald

DRUGS team

32 Citations (Scopus)

Abstract

Background: In schistosomiasis control programmes using mass chemotherapy, epidemiological and morbidity aspects of the disease need to be studied so as to monitor the impact of treatment, and make recommendations accordingly. These aspects were examined in the community of Musoli village along Lake Victoria in Mayuge district, highly endemic for Schistosoma mansoni infection. Methodology and Principal Findings: A cross sectional descriptive study was undertaken in a randomly selected sample of 217 females and 229 males, with a mean age of 26 years (SD ±16, range 7-76 years). The prevalence of S. mansoni was 88.6% (95% CI: 85.6-91.5). The geometric mean intensity (GMI) of S. mansoni was 236.2 (95% CI: 198.5-460.9) eggs per gram (epg) faeces. Males had significantly higher GMI (370.2 epg) than females (132.6 epg) and age was also significantly associated with intensity of infection. Levels of water contact activities significantly influenced intensity of infection and the highest intensity of infection was found among people involved in fishing. However, organomegaly was not significantly associated with S. mansoni except for very heavy infection (>2000 epg). Liver image patterns C and D indicative of fibrosis were found in only 2.2% and 0.2%, respectively. S. mansoni intensity of infection was associated with portal vein dilation and abnormal spleen length. Anaemia was observed in 36.4% of the participants but it was not associated with S. mansoni infection intensity. Considering growth in children as one of the morbidity indicators of schistosomiasis, intensity of S. mansoni was significantly associated with stunting. Conclusion: Although organ-related morbidity, with the exception of periportal fibrosis, and S. mansoni infections were highly prevalent, the two were only associated for individuals with very high infection intensities. These results contrast starkly with reports from Ugandan Lake Albert fishing communities in which periportal fibrosis is more prevalent.

Original language	English
Article number	e2268
Journal	P L o S Neglected Tropical Diseases (Print)
Volume	7
Issue number	7
Number of pages	8
ISSN	1935-2727
DOIs	https://doi.org/10.1371/journal.pntd.0002268
Publication status	Published - Jul 2013

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10.1371/journal.pntd.0002268

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Tukahebwa, E. M., Magnussen, P., Madsen, H., Kabatereine, N. B., Nuwaha, F., Wilson, S., & Vennervald, B. J. (2013). A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria fishing community is required for association with highly prevalent organ related morbidity. P L o S Neglected Tropical Diseases (Print), 7(7), Article e2268. https://doi.org/10.1371/journal.pntd.0002268

A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria fishing community is required for association with highly prevalent organ related morbidity. / Tukahebwa, Edridah M.; Magnussen, Pascal ; Madsen, Henry et al.
In: P L o S Neglected Tropical Diseases (Print), Vol. 7, No. 7, e2268, 07.2013.

Research output: Contribution to journal › Journal article › Research › peer-review

Tukahebwa, EM, Magnussen, P , Madsen, H, Kabatereine, NB, Nuwaha, F, Wilson, S & Vennervald, BJ 2013, 'A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria fishing community is required for association with highly prevalent organ related morbidity', P L o S Neglected Tropical Diseases (Print), vol. 7, no. 7, e2268. https://doi.org/10.1371/journal.pntd.0002268

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title = "A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria fishing community is required for association with highly prevalent organ related morbidity",

abstract = "Background: In schistosomiasis control programmes using mass chemotherapy, epidemiological and morbidity aspects of the disease need to be studied so as to monitor the impact of treatment, and make recommendations accordingly. These aspects were examined in the community of Musoli village along Lake Victoria in Mayuge district, highly endemic for Schistosoma mansoni infection. Methodology and Principal Findings: A cross sectional descriptive study was undertaken in a randomly selected sample of 217 females and 229 males, with a mean age of 26 years (SD ±16, range 7-76 years). The prevalence of S. mansoni was 88.6% (95% CI: 85.6-91.5). The geometric mean intensity (GMI) of S. mansoni was 236.2 (95% CI: 198.5-460.9) eggs per gram (epg) faeces. Males had significantly higher GMI (370.2 epg) than females (132.6 epg) and age was also significantly associated with intensity of infection. Levels of water contact activities significantly influenced intensity of infection and the highest intensity of infection was found among people involved in fishing. However, organomegaly was not significantly associated with S. mansoni except for very heavy infection (>2000 epg). Liver image patterns C and D indicative of fibrosis were found in only 2.2% and 0.2%, respectively. S. mansoni intensity of infection was associated with portal vein dilation and abnormal spleen length. Anaemia was observed in 36.4% of the participants but it was not associated with S. mansoni infection intensity. Considering growth in children as one of the morbidity indicators of schistosomiasis, intensity of S. mansoni was significantly associated with stunting. Conclusion: Although organ-related morbidity, with the exception of periportal fibrosis, and S. mansoni infections were highly prevalent, the two were only associated for individuals with very high infection intensities. These results contrast starkly with reports from Ugandan Lake Albert fishing communities in which periportal fibrosis is more prevalent.",

author = "Tukahebwa, {Edridah M.} and Pascal Magnussen and Henry Madsen and Kabatereine, {Narcis B.} and Fred Nuwaha and Shona Wilson and Vennervald, {Birgitte J}",

year = "2013",

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doi = "10.1371/journal.pntd.0002268",

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volume = "7",

journal = "P L o S Neglected Tropical Diseases (Print)",

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T1 - A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria fishing community is required for association with highly prevalent organ related morbidity

AU - Tukahebwa, Edridah M.

AU - Magnussen, Pascal

AU - Madsen, Henry

AU - Kabatereine, Narcis B.

AU - Nuwaha, Fred

AU - Wilson, Shona

AU - Vennervald, Birgitte J

PY - 2013/7

Y1 - 2013/7

N2 - Background: In schistosomiasis control programmes using mass chemotherapy, epidemiological and morbidity aspects of the disease need to be studied so as to monitor the impact of treatment, and make recommendations accordingly. These aspects were examined in the community of Musoli village along Lake Victoria in Mayuge district, highly endemic for Schistosoma mansoni infection. Methodology and Principal Findings: A cross sectional descriptive study was undertaken in a randomly selected sample of 217 females and 229 males, with a mean age of 26 years (SD ±16, range 7-76 years). The prevalence of S. mansoni was 88.6% (95% CI: 85.6-91.5). The geometric mean intensity (GMI) of S. mansoni was 236.2 (95% CI: 198.5-460.9) eggs per gram (epg) faeces. Males had significantly higher GMI (370.2 epg) than females (132.6 epg) and age was also significantly associated with intensity of infection. Levels of water contact activities significantly influenced intensity of infection and the highest intensity of infection was found among people involved in fishing. However, organomegaly was not significantly associated with S. mansoni except for very heavy infection (>2000 epg). Liver image patterns C and D indicative of fibrosis were found in only 2.2% and 0.2%, respectively. S. mansoni intensity of infection was associated with portal vein dilation and abnormal spleen length. Anaemia was observed in 36.4% of the participants but it was not associated with S. mansoni infection intensity. Considering growth in children as one of the morbidity indicators of schistosomiasis, intensity of S. mansoni was significantly associated with stunting. Conclusion: Although organ-related morbidity, with the exception of periportal fibrosis, and S. mansoni infections were highly prevalent, the two were only associated for individuals with very high infection intensities. These results contrast starkly with reports from Ugandan Lake Albert fishing communities in which periportal fibrosis is more prevalent.

AB - Background: In schistosomiasis control programmes using mass chemotherapy, epidemiological and morbidity aspects of the disease need to be studied so as to monitor the impact of treatment, and make recommendations accordingly. These aspects were examined in the community of Musoli village along Lake Victoria in Mayuge district, highly endemic for Schistosoma mansoni infection. Methodology and Principal Findings: A cross sectional descriptive study was undertaken in a randomly selected sample of 217 females and 229 males, with a mean age of 26 years (SD ±16, range 7-76 years). The prevalence of S. mansoni was 88.6% (95% CI: 85.6-91.5). The geometric mean intensity (GMI) of S. mansoni was 236.2 (95% CI: 198.5-460.9) eggs per gram (epg) faeces. Males had significantly higher GMI (370.2 epg) than females (132.6 epg) and age was also significantly associated with intensity of infection. Levels of water contact activities significantly influenced intensity of infection and the highest intensity of infection was found among people involved in fishing. However, organomegaly was not significantly associated with S. mansoni except for very heavy infection (>2000 epg). Liver image patterns C and D indicative of fibrosis were found in only 2.2% and 0.2%, respectively. S. mansoni intensity of infection was associated with portal vein dilation and abnormal spleen length. Anaemia was observed in 36.4% of the participants but it was not associated with S. mansoni infection intensity. Considering growth in children as one of the morbidity indicators of schistosomiasis, intensity of S. mansoni was significantly associated with stunting. Conclusion: Although organ-related morbidity, with the exception of periportal fibrosis, and S. mansoni infections were highly prevalent, the two were only associated for individuals with very high infection intensities. These results contrast starkly with reports from Ugandan Lake Albert fishing communities in which periportal fibrosis is more prevalent.

U2 - 10.1371/journal.pntd.0002268

DO - 10.1371/journal.pntd.0002268

M3 - Journal article

C2 - 23936559

SN - 1935-2727

VL - 7

JO - P L o S Neglected Tropical Diseases (Print)

JF - P L o S Neglected Tropical Diseases (Print)

IS - 7

M1 - e2268

ER -

A very high infection intensity of Schistosoma mansoni in a Ugandan Lake Victoria fishing community is required for association with highly prevalent organ related morbidity

Abstract

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