A three-year follow-up on the efficacy of psychosocial interventions for patients with mild dementia and their caregivers: the multicentre, rater-blinded, randomized Danish Alzheimer Intervention Study (DAISY).

K.T.T. Phung; F.B. Waldorff; D.V. Buss; A. Eckermann; Niels Keiding; S. Rishøj; V. Siersma; J. Sørensen; R. Søgaard; L. V. Sørensen; A. Vogel; G. Waldemar

doi:10.1136/bmjopen-2013-003584

A three-year follow-up on the efficacy of psychosocial interventions for patients with mild dementia and their caregivers: the multicentre, rater-blinded, randomized Danish Alzheimer Intervention Study (DAISY).

K.T.T. Phung, F.B. Waldorff, D.V. Buss, A. Eckermann, Niels Keiding, S. Rishøj, V. Siersma, J. Sørensen, R. Søgaard, L. V. Sørensen, A. Vogel, G. Waldemar

42 Citations (Scopus)

Abstract

Objectives: To examine the long-term efficacy at the 36-month follow-up of an early psychosocial counselling and support programme lasting 8-12 months for community-dwelling patients with mild Alzheimer's disease and their caregivers. Design: Multicentre, randomised, controlled, raterblinded trial. Setting: Primary care and memory clinics in five Danish districts. Participants: 330 home-dwelling patients with mild Alzheimer's disease and their primary caregivers (dyads). Interventions: Dyads were randomised to receive intervention during the first year after diagnosis. Both intervention and control groups had follow-up visits at 3, 6, 12 and 36 months. Main outcome measures: Primary outcomes for the patients assessed at 36-month follow-up were changes from baseline in global cognitive function (Mini-Mental State Examination), depressive symptoms (Cornell Depression Scale) and proxy-rated EuroQoL quality of life on visual analogue scale. The primary outcomes for the caregivers were changes from baseline in depressive symptoms (Geriatric Depression Scale) and self-rated EuroQoL quality of life on a visual analogue scale. The secondary outcome measures for the patient were proxy-rated Quality of Life Scale for Alzheimer's disease (QoL-AD), Neuropsychiatric Inventory-Questionnaire, Alzheimer's disease Cooperative Study Activities of Daily Living Scale, all-cause mortality and nursing home placement. Results: At a 36-month follow-up, 2 years after the completion of the Danish Alzheimer Intervention Study (DAISY), the unadjusted positive effects previously detected at the 12-month follow-up in one patient primary outcome (Cornell depression score) and one patient secondary outcome ( proxy-rated QoL-AD) disappeared (Cornell depression score, p=0.93; proxy-rated QoL-AD, p=0.81). No long-term effect of DAISY intervention on any other primary and secondary outcomes was found at the 36-month follow-up. Conclusions: For patients with very mild Alzheimer's disease and their caregivers, an intensive, multicomponent, semitailored psychosocial intervention programme with counselling, education and support during the first year after diagnosis did not show any positive long-term effect on primary and secondary outcomes. Trial registration: The study was registered in the Clinical Trial Database (http://www.controlled-trials.com/ISRCTN74848736).

Original language	English
Journal	B M J Open
Volume	3
Issue number	11
ISSN	2044-6055
DOIs	https://doi.org/10.1136/bmjopen-2013-003584
Publication status	Published - 2013

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Phung, K. T. T., Waldorff, F. B., Buss, D. V., Eckermann, A., Keiding, N., Rishøj, S., Siersma, V., Sørensen, J., Søgaard, R., Sørensen, L. V., Vogel, A., & Waldemar, G. (2013). A three-year follow-up on the efficacy of psychosocial interventions for patients with mild dementia and their caregivers: the multicentre, rater-blinded, randomized Danish Alzheimer Intervention Study (DAISY). B M J Open, 3(11). https://doi.org/10.1136/bmjopen-2013-003584

A three-year follow-up on the efficacy of psychosocial interventions for patients with mild dementia and their caregivers: the multicentre, rater-blinded, randomized Danish Alzheimer Intervention Study (DAISY). / Phung, K.T.T.; Waldorff, F.B.; Buss, D.V. et al.
In: B M J Open, Vol. 3, No. 11, 2013.

Research output: Contribution to journal › Journal article › Research › peer-review

Phung, KTT, Waldorff, FB, Buss, DV, Eckermann, A, Keiding, N, Rishøj, S, Siersma, V, Sørensen, J, Søgaard, R, Sørensen, LV, Vogel, A & Waldemar, G 2013, 'A three-year follow-up on the efficacy of psychosocial interventions for patients with mild dementia and their caregivers: the multicentre, rater-blinded, randomized Danish Alzheimer Intervention Study (DAISY).', B M J Open, vol. 3, no. 11. https://doi.org/10.1136/bmjopen-2013-003584

@article{35a2df07587b42abad886fb4e224cb46,

title = "A three-year follow-up on the efficacy of psychosocial interventions for patients with mild dementia and their caregivers: the multicentre, rater-blinded, randomized Danish Alzheimer Intervention Study (DAISY).",

abstract = "Objectives: To examine the long-term efficacy at the 36-month follow-up of an early psychosocial counselling and support programme lasting 8-12 months for community-dwelling patients with mild Alzheimer's disease and their caregivers. Design: Multicentre, randomised, controlled, raterblinded trial. Setting: Primary care and memory clinics in five Danish districts. Participants: 330 home-dwelling patients with mild Alzheimer's disease and their primary caregivers (dyads). Interventions: Dyads were randomised to receive intervention during the first year after diagnosis. Both intervention and control groups had follow-up visits at 3, 6, 12 and 36 months. Main outcome measures: Primary outcomes for the patients assessed at 36-month follow-up were changes from baseline in global cognitive function (Mini-Mental State Examination), depressive symptoms (Cornell Depression Scale) and proxy-rated EuroQoL quality of life on visual analogue scale. The primary outcomes for the caregivers were changes from baseline in depressive symptoms (Geriatric Depression Scale) and self-rated EuroQoL quality of life on a visual analogue scale. The secondary outcome measures for the patient were proxy-rated Quality of Life Scale for Alzheimer's disease (QoL-AD), Neuropsychiatric Inventory-Questionnaire, Alzheimer's disease Cooperative Study Activities of Daily Living Scale, all-cause mortality and nursing home placement. Results: At a 36-month follow-up, 2 years after the completion of the Danish Alzheimer Intervention Study (DAISY), the unadjusted positive effects previously detected at the 12-month follow-up in one patient primary outcome (Cornell depression score) and one patient secondary outcome ( proxy-rated QoL-AD) disappeared (Cornell depression score, p=0.93; proxy-rated QoL-AD, p=0.81). No long-term effect of DAISY intervention on any other primary and secondary outcomes was found at the 36-month follow-up. Conclusions: For patients with very mild Alzheimer's disease and their caregivers, an intensive, multicomponent, semitailored psychosocial intervention programme with counselling, education and support during the first year after diagnosis did not show any positive long-term effect on primary and secondary outcomes. Trial registration: The study was registered in the Clinical Trial Database (http://www.controlled-trials.com/ISRCTN74848736).",

keywords = "Caregivers, Dementia, Intervention Studies, PATIENT, Patients, semrap-2013-3",

author = "K.T.T. Phung and F.B. Waldorff and D.V. Buss and A. Eckermann and Niels Keiding and S. Rish{\o}j and V. Siersma and J. S{\o}rensen and R. S{\o}gaard and S{\o}rensen, {L. V.} and A. Vogel and G. Waldemar",

year = "2013",

doi = "10.1136/bmjopen-2013-003584",

language = "English",

volume = "3",

journal = "B M J Open",

issn = "2044-6055",

publisher = "BMJ Publishing Group",

number = "11",

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TY - JOUR

T1 - A three-year follow-up on the efficacy of psychosocial interventions for patients with mild dementia and their caregivers: the multicentre, rater-blinded, randomized Danish Alzheimer Intervention Study (DAISY).

AU - Phung, K.T.T.

AU - Waldorff, F.B.

AU - Buss, D.V.

AU - Eckermann, A.

AU - Keiding, Niels

AU - Rishøj, S.

AU - Siersma, V.

AU - Sørensen, J.

AU - Søgaard, R.

AU - Sørensen, L. V.

AU - Vogel, A.

AU - Waldemar, G.

PY - 2013

Y1 - 2013

N2 - Objectives: To examine the long-term efficacy at the 36-month follow-up of an early psychosocial counselling and support programme lasting 8-12 months for community-dwelling patients with mild Alzheimer's disease and their caregivers. Design: Multicentre, randomised, controlled, raterblinded trial. Setting: Primary care and memory clinics in five Danish districts. Participants: 330 home-dwelling patients with mild Alzheimer's disease and their primary caregivers (dyads). Interventions: Dyads were randomised to receive intervention during the first year after diagnosis. Both intervention and control groups had follow-up visits at 3, 6, 12 and 36 months. Main outcome measures: Primary outcomes for the patients assessed at 36-month follow-up were changes from baseline in global cognitive function (Mini-Mental State Examination), depressive symptoms (Cornell Depression Scale) and proxy-rated EuroQoL quality of life on visual analogue scale. The primary outcomes for the caregivers were changes from baseline in depressive symptoms (Geriatric Depression Scale) and self-rated EuroQoL quality of life on a visual analogue scale. The secondary outcome measures for the patient were proxy-rated Quality of Life Scale for Alzheimer's disease (QoL-AD), Neuropsychiatric Inventory-Questionnaire, Alzheimer's disease Cooperative Study Activities of Daily Living Scale, all-cause mortality and nursing home placement. Results: At a 36-month follow-up, 2 years after the completion of the Danish Alzheimer Intervention Study (DAISY), the unadjusted positive effects previously detected at the 12-month follow-up in one patient primary outcome (Cornell depression score) and one patient secondary outcome ( proxy-rated QoL-AD) disappeared (Cornell depression score, p=0.93; proxy-rated QoL-AD, p=0.81). No long-term effect of DAISY intervention on any other primary and secondary outcomes was found at the 36-month follow-up. Conclusions: For patients with very mild Alzheimer's disease and their caregivers, an intensive, multicomponent, semitailored psychosocial intervention programme with counselling, education and support during the first year after diagnosis did not show any positive long-term effect on primary and secondary outcomes. Trial registration: The study was registered in the Clinical Trial Database (http://www.controlled-trials.com/ISRCTN74848736).

AB - Objectives: To examine the long-term efficacy at the 36-month follow-up of an early psychosocial counselling and support programme lasting 8-12 months for community-dwelling patients with mild Alzheimer's disease and their caregivers. Design: Multicentre, randomised, controlled, raterblinded trial. Setting: Primary care and memory clinics in five Danish districts. Participants: 330 home-dwelling patients with mild Alzheimer's disease and their primary caregivers (dyads). Interventions: Dyads were randomised to receive intervention during the first year after diagnosis. Both intervention and control groups had follow-up visits at 3, 6, 12 and 36 months. Main outcome measures: Primary outcomes for the patients assessed at 36-month follow-up were changes from baseline in global cognitive function (Mini-Mental State Examination), depressive symptoms (Cornell Depression Scale) and proxy-rated EuroQoL quality of life on visual analogue scale. The primary outcomes for the caregivers were changes from baseline in depressive symptoms (Geriatric Depression Scale) and self-rated EuroQoL quality of life on a visual analogue scale. The secondary outcome measures for the patient were proxy-rated Quality of Life Scale for Alzheimer's disease (QoL-AD), Neuropsychiatric Inventory-Questionnaire, Alzheimer's disease Cooperative Study Activities of Daily Living Scale, all-cause mortality and nursing home placement. Results: At a 36-month follow-up, 2 years after the completion of the Danish Alzheimer Intervention Study (DAISY), the unadjusted positive effects previously detected at the 12-month follow-up in one patient primary outcome (Cornell depression score) and one patient secondary outcome ( proxy-rated QoL-AD) disappeared (Cornell depression score, p=0.93; proxy-rated QoL-AD, p=0.81). No long-term effect of DAISY intervention on any other primary and secondary outcomes was found at the 36-month follow-up. Conclusions: For patients with very mild Alzheimer's disease and their caregivers, an intensive, multicomponent, semitailored psychosocial intervention programme with counselling, education and support during the first year after diagnosis did not show any positive long-term effect on primary and secondary outcomes. Trial registration: The study was registered in the Clinical Trial Database (http://www.controlled-trials.com/ISRCTN74848736).

KW - Caregivers

KW - Dementia

KW - Intervention Studies

KW - PATIENT

KW - Patients

KW - semrap-2013-3

U2 - 10.1136/bmjopen-2013-003584

DO - 10.1136/bmjopen-2013-003584

M3 - Journal article

C2 - 24270834

SN - 2044-6055

VL - 3

JO - B M J Open

JF - B M J Open

IS - 11

ER -