A systematic review on the safety and efficacy of percutaneous edge-to-edge mitral valve repair with the MitraClip system for high surgical risk candidates

Stine Munkholm-Larsen; Benjamin Wan; David H Tian; Katherine Kearney; Mohammad Rahnavardi; Ulrik Dixen; Lars Køber; Ottavio Alfieri; Tristan D Yan

doi:10.1136/heartjnl-2013-304049

A systematic review on the safety and efficacy of percutaneous edge-to-edge mitral valve repair with the MitraClip system for high surgical risk candidates

Stine Munkholm-Larsen, Benjamin Wan, David H Tian, Katherine Kearney, Mohammad Rahnavardi, Ulrik Dixen, Lars Køber, Ottavio Alfieri, Tristan D Yan

Department of Clinical Medicine

40 Citations (Scopus)

Abstract

BACKGROUND: MitraClip implantation has emerged as a viable option in high surgical risk patients with severe mitral regurgitation (MR). We performed the present systematic review to assess the safety and efficacy of the MitraClip system for high surgical risk candidates with severe organic and/or functional MR.

METHODS: Six electronic databases were searched for original published studies from January 2000 to March 2013. Two reviewers independently appraised studies, using a standard form, and extracted data on methodology, quality criteria, and outcome measures. All data were extracted and tabulated from the relevant articles' texts, tables, and figures and checked by another reviewer.

RESULTS: Overall 111 publications were identified. After applying selection criteria and removing serial publications with accumulating number of patients or increased length of follow-up, 12 publications with the most complete dataset were included for quality appraisal and data extraction. All 12 studies were prospective observational studies. Immediate procedural success ranged from 72-100%; 30 day mortality ranged from 0-7.8%. There was a significant improvement in haemodynamic profile and functional status after implantation. One year survival ranged from 75-90%. No long term outcomes have been reported for high surgical risk patients.

CONCLUSIONS: MitraClip implantation is an option in managing selected high surgical risk patients with severe MR. The current evidence suggests that MitraClip can be implanted with reproducible safety and feasibility profile in this subgroup of patients. Further prospective trials with mid- to long-term follow-up are required.

Original language	English
Journal	Heart
Volume	100
Issue number	6
Pages (from-to)	473-478
Number of pages	6
ISSN	1355-6037
DOIs	https://doi.org/10.1136/heartjnl-2013-304049
Publication status	Published - Mar 2014

Keywords

Cardiac Catheterization
Global Health
Heart Valve Prosthesis
Hemodynamics
Humans
Mitral Valve
Mitral Valve Insufficiency
Prosthesis Design
Risk Factors
Severity of Illness Index
Survival Rate

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10.1136/heartjnl-2013-304049

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@article{d0e4a12931224441bd782b49496065f4,

title = "A systematic review on the safety and efficacy of percutaneous edge-to-edge mitral valve repair with the MitraClip system for high surgical risk candidates",

abstract = "BACKGROUND: MitraClip implantation has emerged as a viable option in high surgical risk patients with severe mitral regurgitation (MR). We performed the present systematic review to assess the safety and efficacy of the MitraClip system for high surgical risk candidates with severe organic and/or functional MR.METHODS: Six electronic databases were searched for original published studies from January 2000 to March 2013. Two reviewers independently appraised studies, using a standard form, and extracted data on methodology, quality criteria, and outcome measures. All data were extracted and tabulated from the relevant articles' texts, tables, and figures and checked by another reviewer.RESULTS: Overall 111 publications were identified. After applying selection criteria and removing serial publications with accumulating number of patients or increased length of follow-up, 12 publications with the most complete dataset were included for quality appraisal and data extraction. All 12 studies were prospective observational studies. Immediate procedural success ranged from 72-100%; 30 day mortality ranged from 0-7.8%. There was a significant improvement in haemodynamic profile and functional status after implantation. One year survival ranged from 75-90%. No long term outcomes have been reported for high surgical risk patients.CONCLUSIONS: MitraClip implantation is an option in managing selected high surgical risk patients with severe MR. The current evidence suggests that MitraClip can be implanted with reproducible safety and feasibility profile in this subgroup of patients. Further prospective trials with mid- to long-term follow-up are required.",

keywords = "Cardiac Catheterization, Global Health, Heart Valve Prosthesis, Hemodynamics, Humans, Mitral Valve, Mitral Valve Insufficiency, Prosthesis Design, Risk Factors, Severity of Illness Index, Survival Rate",

author = "Stine Munkholm-Larsen and Benjamin Wan and Tian, {David H} and Katherine Kearney and Mohammad Rahnavardi and Ulrik Dixen and Lars K{\o}ber and Ottavio Alfieri and Yan, {Tristan D}",

year = "2014",

month = mar,

doi = "10.1136/heartjnl-2013-304049",

language = "English",

volume = "100",

pages = "473--478",

journal = "Heart",

issn = "1355-6037",

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T1 - A systematic review on the safety and efficacy of percutaneous edge-to-edge mitral valve repair with the MitraClip system for high surgical risk candidates

AU - Munkholm-Larsen, Stine

AU - Wan, Benjamin

AU - Tian, David H

AU - Kearney, Katherine

AU - Rahnavardi, Mohammad

AU - Dixen, Ulrik

AU - Køber, Lars

AU - Alfieri, Ottavio

AU - Yan, Tristan D

PY - 2014/3

Y1 - 2014/3

N2 - BACKGROUND: MitraClip implantation has emerged as a viable option in high surgical risk patients with severe mitral regurgitation (MR). We performed the present systematic review to assess the safety and efficacy of the MitraClip system for high surgical risk candidates with severe organic and/or functional MR.METHODS: Six electronic databases were searched for original published studies from January 2000 to March 2013. Two reviewers independently appraised studies, using a standard form, and extracted data on methodology, quality criteria, and outcome measures. All data were extracted and tabulated from the relevant articles' texts, tables, and figures and checked by another reviewer.RESULTS: Overall 111 publications were identified. After applying selection criteria and removing serial publications with accumulating number of patients or increased length of follow-up, 12 publications with the most complete dataset were included for quality appraisal and data extraction. All 12 studies were prospective observational studies. Immediate procedural success ranged from 72-100%; 30 day mortality ranged from 0-7.8%. There was a significant improvement in haemodynamic profile and functional status after implantation. One year survival ranged from 75-90%. No long term outcomes have been reported for high surgical risk patients.CONCLUSIONS: MitraClip implantation is an option in managing selected high surgical risk patients with severe MR. The current evidence suggests that MitraClip can be implanted with reproducible safety and feasibility profile in this subgroup of patients. Further prospective trials with mid- to long-term follow-up are required.

AB - BACKGROUND: MitraClip implantation has emerged as a viable option in high surgical risk patients with severe mitral regurgitation (MR). We performed the present systematic review to assess the safety and efficacy of the MitraClip system for high surgical risk candidates with severe organic and/or functional MR.METHODS: Six electronic databases were searched for original published studies from January 2000 to March 2013. Two reviewers independently appraised studies, using a standard form, and extracted data on methodology, quality criteria, and outcome measures. All data were extracted and tabulated from the relevant articles' texts, tables, and figures and checked by another reviewer.RESULTS: Overall 111 publications were identified. After applying selection criteria and removing serial publications with accumulating number of patients or increased length of follow-up, 12 publications with the most complete dataset were included for quality appraisal and data extraction. All 12 studies were prospective observational studies. Immediate procedural success ranged from 72-100%; 30 day mortality ranged from 0-7.8%. There was a significant improvement in haemodynamic profile and functional status after implantation. One year survival ranged from 75-90%. No long term outcomes have been reported for high surgical risk patients.CONCLUSIONS: MitraClip implantation is an option in managing selected high surgical risk patients with severe MR. The current evidence suggests that MitraClip can be implanted with reproducible safety and feasibility profile in this subgroup of patients. Further prospective trials with mid- to long-term follow-up are required.

KW - Cardiac Catheterization

KW - Global Health

KW - Heart Valve Prosthesis

KW - Hemodynamics

KW - Humans

KW - Mitral Valve

KW - Mitral Valve Insufficiency

KW - Prosthesis Design

KW - Risk Factors

KW - Severity of Illness Index

KW - Survival Rate

U2 - 10.1136/heartjnl-2013-304049

DO - 10.1136/heartjnl-2013-304049

M3 - Review

C2 - 23813844

SN - 1355-6037

VL - 100

SP - 473

EP - 478

JO - Heart

JF - Heart

IS - 6

ER -

A systematic review on the safety and efficacy of percutaneous edge-to-edge mitral valve repair with the MitraClip system for high surgical risk candidates

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Keywords

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