TY - JOUR
T1 - A structurally diverse library of safe-by-design citrem-phospholipid lamellar and non-lamellar liquid crystalline nano-assemblies
AU - Mat Azmi, Intan Diana Binti
AU - Wibroe, Peter Popp
AU - Wu, Lin-Ping
AU - Kazem, Ali I
AU - Amenitsch, Heinz
AU - Moghimi, Seyed Moien
AU - Yaghmur, Anan
N1 - Copyright © 2016. Published by Elsevier B.V.
PY - 2016/10/10
Y1 - 2016/10/10
N2 - Non-lamellar liquid crystalline aqueous nanodispersions, known also as ISAsomes (internally self-assembled ‘somes’ or nanoparticles), are gaining increasing interest in drug solubilisation and bio-imaging, but they often exhibit poor hemocompatibility and induce cytotoxicity. This limits their applications in intravenous drug delivery and targeting. Using a binary mixture of citrem and soy phosphatidylcholine (SPC) at different weight ratios, we describe a library of colloidally stable aqueous and hemocompatible nanodispersions of diverse nanoarchitectures (internal self-assembled nanostructures). This engineered library is structurally stable in human plasma as well as being hemocompatible (non-hemolytic, and poor activator of the complement system). By varying citrem to lipid weight ratio, the nanodispersion susceptibility to macrophage uptake could also be modulated. Finally, the formation of nanodispersions comprising internally V2 (inverse bicontinuous cubic) and H2 (inverse hexagonal) nanoarchitectures was achieved without the use of an organic solvent, a secondary emulsifier, or high-energy input. The tunable binary citrem/SPC nanoplatform holds promise for future development of hemocompatible and immune-safe nanopharmaceuticals.
AB - Non-lamellar liquid crystalline aqueous nanodispersions, known also as ISAsomes (internally self-assembled ‘somes’ or nanoparticles), are gaining increasing interest in drug solubilisation and bio-imaging, but they often exhibit poor hemocompatibility and induce cytotoxicity. This limits their applications in intravenous drug delivery and targeting. Using a binary mixture of citrem and soy phosphatidylcholine (SPC) at different weight ratios, we describe a library of colloidally stable aqueous and hemocompatible nanodispersions of diverse nanoarchitectures (internal self-assembled nanostructures). This engineered library is structurally stable in human plasma as well as being hemocompatible (non-hemolytic, and poor activator of the complement system). By varying citrem to lipid weight ratio, the nanodispersion susceptibility to macrophage uptake could also be modulated. Finally, the formation of nanodispersions comprising internally V2 (inverse bicontinuous cubic) and H2 (inverse hexagonal) nanoarchitectures was achieved without the use of an organic solvent, a secondary emulsifier, or high-energy input. The tunable binary citrem/SPC nanoplatform holds promise for future development of hemocompatible and immune-safe nanopharmaceuticals.
U2 - 10.1016/j.jconrel.2016.08.011
DO - 10.1016/j.jconrel.2016.08.011
M3 - Journal article
C2 - 27524284
SN - 0168-3659
VL - 239
SP - 1
EP - 9
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -