A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps

Jens Preben Morth; Bjørn Panella Pedersen; Morten Jeppe Buch-Pedersen; Jens Peter Andersen; Bente Vilsen; Michael Broberg Palmgren; Poul Nissen

doi:10.1038/nrm3031

A structural overview of the plasma membrane Na⁺,K⁺-ATPase and H⁺-ATPase ion pumps

Jens Preben Morth, Bjørn Panella Pedersen, Morten Jeppe Buch-Pedersen, Jens Peter Andersen, Bente Vilsen, Michael Broberg Palmgren, Poul Nissen

199 Citations (Scopus)

Abstract

Plasma membrane ATPases are primary active transporters of cations that maintain steep concentration gradients. The ion gradients and membrane potentials derived from them form the basis for a range of essential cellular processes, in particular Na(+)-dependent and proton-dependent secondary transport systems that are responsible for uptake and extrusion of metabolites and other ions. The ion gradients are also both directly and indirectly used to control pH homeostasis and to regulate cell volume. The plasma membrane H(+)-ATPase maintains a proton gradient in plants and fungi and the Na(+),K(+)-ATPase maintains a Na(+) and K(+) gradient in animal cells. Structural information provides insight into the function of these two distinct but related P-type pumps.

Original language	English
Journal	Nature Reviews. Molecular Cell Biology
Volume	12
Issue number	1
Pages (from-to)	60-70
Number of pages	11
ISSN	1471-0072
DOIs	https://doi.org/10.1038/nrm3031
Publication status	Published - Jan 2011

Keywords

Animals
Cell Membrane
Humans
Proton-Translocating ATPases
Sodium-Potassium-Exchanging ATPase

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10.1038/nrm3031

Cite this

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abstract = "Plasma membrane ATPases are primary active transporters of cations that maintain steep concentration gradients. The ion gradients and membrane potentials derived from them form the basis for a range of essential cellular processes, in particular Na(+)-dependent and proton-dependent secondary transport systems that are responsible for uptake and extrusion of metabolites and other ions. The ion gradients are also both directly and indirectly used to control pH homeostasis and to regulate cell volume. The plasma membrane H(+)-ATPase maintains a proton gradient in plants and fungi and the Na(+),K(+)-ATPase maintains a Na(+) and K(+) gradient in animal cells. Structural information provides insight into the function of these two distinct but related P-type pumps.",

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AU - Morth, Jens Preben

AU - Pedersen, Bjørn Panella

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AU - Andersen, Jens Peter

AU - Vilsen, Bente

AU - Palmgren, Michael Broberg

AU - Nissen, Poul

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AB - Plasma membrane ATPases are primary active transporters of cations that maintain steep concentration gradients. The ion gradients and membrane potentials derived from them form the basis for a range of essential cellular processes, in particular Na(+)-dependent and proton-dependent secondary transport systems that are responsible for uptake and extrusion of metabolites and other ions. The ion gradients are also both directly and indirectly used to control pH homeostasis and to regulate cell volume. The plasma membrane H(+)-ATPase maintains a proton gradient in plants and fungi and the Na(+),K(+)-ATPase maintains a Na(+) and K(+) gradient in animal cells. Structural information provides insight into the function of these two distinct but related P-type pumps.

KW - Animals

KW - Cell Membrane

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KW - Proton-Translocating ATPases

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