A structural MRI study of excoriation (skin-picking) disorder and its relationship to clinical severity

TY - JOUR

T1 - A structural MRI study of excoriation (skin-picking) disorder and its relationship to clinical severity

AU - Harries, Michael D.

AU - Chamberlain, Samuel R.

AU - Redden, Sarah A.

AU - Odlaug, Brian L.

AU - Blum, Austin W.

AU - Grant, Jon E.

PY - 2017

Y1 - 2017

N2 - Excoriation (skin-picking) disorder (SPD) shares symptomology with other obsessive-compulsive and related disorders. Few studies, however, have examined the neurological profile of patients with SPD. This study examined differences in cortical thickness and basal ganglia structural volumes between 20 individuals with SPD and 16 healthy controls using magnetic resonance imaging (MRI). There were no significant differences in demographic variables (age, gender, education and race) between groups. All subjects completed a structural MRI scan and completed a battery of clinical assessments focusing on SPD symptom severity, depression and anxiety symptoms, and quality of life. No statistically significant differences in basal ganglia (caudate, putamen, and nucleus accumbens) structural volumes were found between groups. In individuals with SPD, increasing impulsiveness correlated positively with increased cortical thickness in the left insula, and skin picking severity correlated negatively with cortical thickness in the left supramarginal gyrus and a region encompassing the right inferior parietal, right temporal and right supramarginal gyrus. This study suggests similarities and differences exist in symptomology between SPD and the other obsessive-compulsive and related disorders. Additional neuroimaging research is needed to better delineate the underlying neurobiology of SPD.

AB - Excoriation (skin-picking) disorder (SPD) shares symptomology with other obsessive-compulsive and related disorders. Few studies, however, have examined the neurological profile of patients with SPD. This study examined differences in cortical thickness and basal ganglia structural volumes between 20 individuals with SPD and 16 healthy controls using magnetic resonance imaging (MRI). There were no significant differences in demographic variables (age, gender, education and race) between groups. All subjects completed a structural MRI scan and completed a battery of clinical assessments focusing on SPD symptom severity, depression and anxiety symptoms, and quality of life. No statistically significant differences in basal ganglia (caudate, putamen, and nucleus accumbens) structural volumes were found between groups. In individuals with SPD, increasing impulsiveness correlated positively with increased cortical thickness in the left insula, and skin picking severity correlated negatively with cortical thickness in the left supramarginal gyrus and a region encompassing the right inferior parietal, right temporal and right supramarginal gyrus. This study suggests similarities and differences exist in symptomology between SPD and the other obsessive-compulsive and related disorders. Additional neuroimaging research is needed to better delineate the underlying neurobiology of SPD.

KW - Brain imaging

KW - Cortical thickness

KW - Obsessive-compulsive

KW - Skin picking disorder

KW - Structural volume

U2 - 10.1016/j.pscychresns.2017.09.006

DO - 10.1016/j.pscychresns.2017.09.006

M3 - Journal article

C2 - 28918268

AN - SCOPUS:85029377038

SN - 0925-4927

VL - 269

SP - 26

EP - 30

JO - Psychiatry Research: Neuroimaging

JF - Psychiatry Research: Neuroimaging

ER -