A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study

Ronald B Postuma; Isabelle Arnulf; Birgit Hogl; Alex Iranzo; Tomoyuki Miyamoto; Yves Dauvilliers; Wolfgang Oertel; Yo-El Ju; Monica Puligheddu; Poul Jennum; Amelie Pelletier; Christina Wolfson; Smaranda Leu-Semenescu; Birgit Frauscher; Masayuki Miyamoto; Valerie Cochen De Cock; Marcus M Unger; Karin Stiasny-Kolster; Maria Livia Fantini; Jacques Y Montplaisir

doi:10.1002/mds.25037

A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study

Ronald B Postuma, Isabelle Arnulf, Birgit Hogl, Alex Iranzo, Tomoyuki Miyamoto, Yves Dauvilliers, Wolfgang Oertel, Yo-El Ju, Monica Puligheddu, Poul Jennum, Amelie Pelletier, Christina Wolfson, Smaranda Leu-Semenescu, Birgit Frauscher, Masayuki Miyamoto, Valerie Cochen De Cock, Marcus M Unger, Karin Stiasny-Kolster, Maria Livia Fantini, Jacques Y Montplaisir

192 Citations (Scopus)

Abstract

Background: Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia that is an important risk factor for Parkinson's disease (PD) and Lewy body dementia. Its prevalence is unknown. One barrier to determining prevalence is that current screening tools are too long for large-scale epidemiologic surveys. Therefore, we designed the REM Sleep Behavior Disorder Single-Question Screen (RBD1Q), a screening question for dream enactment with a simple yes/no response. Methods:: Four hundred and eighty-four sleep-clinic-based participants (242 idiopathic RBD patients and 242 controls) completed the screen during a multicenter case-control study. All participants underwent a polysomnogram to define gold-standard diagnosis according to standard criteria. Results:: We found a sensitivity of 93.8% and a specificity of 87.2%. Sensitivity and specificity were similar in healthy volunteers, compared to controls or patients with other sleep diagnoses. Conclusions:: A single-question screen for RBD may reliably detect disease, with psychometric properties favorably comparable to those reported for longer questionnaires.

Original language	English
Journal	Movement Disorders
Volume	27
Issue number	7
Pages (from-to)	913-6
Number of pages	4
ISSN	0885-3185
DOIs	https://doi.org/10.1002/mds.25037
Publication status	Published - Jun 2012

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Postuma, R. B., Arnulf, I., Hogl, B., Iranzo, A., Miyamoto, T., Dauvilliers, Y., Oertel, W., Ju, Y-E., Puligheddu, M., Jennum, P., Pelletier, A., Wolfson, C., Leu-Semenescu, S., Frauscher, B., Miyamoto, M., Cochen De Cock, V., Unger, M. M., Stiasny-Kolster, K., Fantini, M. L., & Montplaisir, J. Y. (2012). A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study. Movement Disorders, 27(7), 913-6. https://doi.org/10.1002/mds.25037

Postuma, RB, Arnulf, I, Hogl, B, Iranzo, A, Miyamoto, T, Dauvilliers, Y, Oertel, W, Ju, Y-E, Puligheddu, M, Jennum, P, Pelletier, A, Wolfson, C, Leu-Semenescu, S, Frauscher, B, Miyamoto, M, Cochen De Cock, V, Unger, MM, Stiasny-Kolster, K, Fantini, ML & Montplaisir, JY 2012, 'A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study', Movement Disorders, vol. 27, no. 7, pp. 913-6. https://doi.org/10.1002/mds.25037

@article{c30f7631bcee4fba91263a453ada0568,

title = "A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study",

abstract = "Background: Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia that is an important risk factor for Parkinson's disease (PD) and Lewy body dementia. Its prevalence is unknown. One barrier to determining prevalence is that current screening tools are too long for large-scale epidemiologic surveys. Therefore, we designed the REM Sleep Behavior Disorder Single-Question Screen (RBD1Q), a screening question for dream enactment with a simple yes/no response. Methods:: Four hundred and eighty-four sleep-clinic-based participants (242 idiopathic RBD patients and 242 controls) completed the screen during a multicenter case-control study. All participants underwent a polysomnogram to define gold-standard diagnosis according to standard criteria. Results:: We found a sensitivity of 93.8% and a specificity of 87.2%. Sensitivity and specificity were similar in healthy volunteers, compared to controls or patients with other sleep diagnoses. Conclusions:: A single-question screen for RBD may reliably detect disease, with psychometric properties favorably comparable to those reported for longer questionnaires.",

author = "Postuma, {Ronald B} and Isabelle Arnulf and Birgit Hogl and Alex Iranzo and Tomoyuki Miyamoto and Yves Dauvilliers and Wolfgang Oertel and Yo-El Ju and Monica Puligheddu and Poul Jennum and Amelie Pelletier and Christina Wolfson and Smaranda Leu-Semenescu and Birgit Frauscher and Masayuki Miyamoto and {Cochen De Cock}, Valerie and Unger, {Marcus M} and Karin Stiasny-Kolster and Fantini, {Maria Livia} and Montplaisir, {Jacques Y}",

note = "Copyright {\textcopyright} 2012 Movement Disorder Society.",

year = "2012",

month = jun,

doi = "10.1002/mds.25037",

language = "English",

volume = "27",

pages = "913--6",

journal = "Movement Disorders",

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TY - JOUR

T1 - A single-question screen for rapid eye movement sleep behavior disorder

T2 - a multicenter validation study

AU - Postuma, Ronald B

AU - Arnulf, Isabelle

AU - Hogl, Birgit

AU - Iranzo, Alex

AU - Miyamoto, Tomoyuki

AU - Dauvilliers, Yves

AU - Oertel, Wolfgang

AU - Ju, Yo-El

AU - Puligheddu, Monica

AU - Jennum, Poul

AU - Pelletier, Amelie

AU - Wolfson, Christina

AU - Leu-Semenescu, Smaranda

AU - Frauscher, Birgit

AU - Miyamoto, Masayuki

AU - Cochen De Cock, Valerie

AU - Unger, Marcus M

AU - Stiasny-Kolster, Karin

AU - Fantini, Maria Livia

AU - Montplaisir, Jacques Y

PY - 2012/6

Y1 - 2012/6

N2 - Background: Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia that is an important risk factor for Parkinson's disease (PD) and Lewy body dementia. Its prevalence is unknown. One barrier to determining prevalence is that current screening tools are too long for large-scale epidemiologic surveys. Therefore, we designed the REM Sleep Behavior Disorder Single-Question Screen (RBD1Q), a screening question for dream enactment with a simple yes/no response. Methods:: Four hundred and eighty-four sleep-clinic-based participants (242 idiopathic RBD patients and 242 controls) completed the screen during a multicenter case-control study. All participants underwent a polysomnogram to define gold-standard diagnosis according to standard criteria. Results:: We found a sensitivity of 93.8% and a specificity of 87.2%. Sensitivity and specificity were similar in healthy volunteers, compared to controls or patients with other sleep diagnoses. Conclusions:: A single-question screen for RBD may reliably detect disease, with psychometric properties favorably comparable to those reported for longer questionnaires.

AB - Background: Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia that is an important risk factor for Parkinson's disease (PD) and Lewy body dementia. Its prevalence is unknown. One barrier to determining prevalence is that current screening tools are too long for large-scale epidemiologic surveys. Therefore, we designed the REM Sleep Behavior Disorder Single-Question Screen (RBD1Q), a screening question for dream enactment with a simple yes/no response. Methods:: Four hundred and eighty-four sleep-clinic-based participants (242 idiopathic RBD patients and 242 controls) completed the screen during a multicenter case-control study. All participants underwent a polysomnogram to define gold-standard diagnosis according to standard criteria. Results:: We found a sensitivity of 93.8% and a specificity of 87.2%. Sensitivity and specificity were similar in healthy volunteers, compared to controls or patients with other sleep diagnoses. Conclusions:: A single-question screen for RBD may reliably detect disease, with psychometric properties favorably comparable to those reported for longer questionnaires.

U2 - 10.1002/mds.25037

DO - 10.1002/mds.25037

M3 - Journal article

C2 - 22729987

SN - 0885-3185

VL - 27

SP - 913

EP - 916

JO - Movement Disorders

JF - Movement Disorders

IS - 7

ER -

A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study

Abstract

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