A simplified laminin nomenclature

Monique Aumailley; Leena Bruckner-Tudermann; William G. Carter; Rainer Deutzmann; David Edgar; Peter Ekblom; Jürgen Engels; Eva Engvall; Erhard Hohenester; Jonathan C.R. Jones; Hynda K. Kleinman; M. Peter Marinkovich; George R. Martin; Ulrike Mayer; Guerrino Meneguzzi; Jeffrey H. Miner; Kaoru Miyazaki; Manuel Patarroyo; Mats Paulsson; Vito Quaranta; Joshua R. Sanes; Takako Sasaki; Kiyotoshi Sekiguchi; Lydia M. Sorokin; Jan Fredrik Talts; Karl Tryggvason; Jouni Uitto; Ismo Virtanen; Klauv von der Mark; U Wewer; Yoshihiko Yamada; Peter D. Yurchenco

doi:10.1016/j.matbio.2005.05.006

A simplified laminin nomenclature

Monique Aumailley, Leena Bruckner-Tudermann, William G. Carter, Rainer Deutzmann, David Edgar, Peter Ekblom, Jürgen Engels, Eva Engvall, Erhard Hohenester, Jonathan C.R. Jones, Hynda K. Kleinman, M. Peter Marinkovich, George R. Martin, Ulrike Mayer, Guerrino Meneguzzi, Jeffrey H. Miner, Kaoru Miyazaki, Manuel Patarroyo, Mats Paulsson, Vito QuarantaJoshua R. Sanes, Takako Sasaki, Kiyotoshi Sekiguchi, Lydia M. Sorokin, Jan Fredrik Talts, Karl Tryggvason, Jouni Uitto, Ismo Virtanen, Klauv von der Mark, U Wewer, Yoshihiko Yamada, Peter D. Yurchenco

579 Citations (Scopus)

Abstract

A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha5beta1gamma1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of beta chains is named laminin beta-knob (Lbeta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha1L4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered.

Original language	English
Journal	Matrix Biology
Volume	24
Issue number	5
Pages (from-to)	326-332
Number of pages	7
ISSN	0945-053X
DOIs	https://doi.org/10.1016/j.matbio.2005.05.006
Publication status	Published - 2005

Keywords

Animals
Humans
Laminin
Terminology as Topic

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10.1016/j.matbio.2005.05.006

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Aumailley, M., Bruckner-Tudermann, L., Carter, W. G., Deutzmann, R., Edgar, D., Ekblom, P., Engels, J., Engvall, E., Hohenester, E., Jones, J. C. R., Kleinman, H. K., Marinkovich, M. P., Martin, G. R., Mayer, U., Meneguzzi, G., Miner, J. H., Miyazaki, K., Patarroyo, M., Paulsson, M., ... Yurchenco, P. D. (2005). A simplified laminin nomenclature. Matrix Biology, 24(5), 326-332. https://doi.org/10.1016/j.matbio.2005.05.006

Aumailley, M, Bruckner-Tudermann, L, Carter, WG, Deutzmann, R, Edgar, D, Ekblom, P, Engels, J, Engvall, E, Hohenester, E, Jones, JCR, Kleinman, HK, Marinkovich, MP, Martin, GR, Mayer, U, Meneguzzi, G, Miner, JH, Miyazaki, K, Patarroyo, M, Paulsson, M, Quaranta, V, Sanes, JR, Sasaki, T, Sekiguchi, K, Sorokin, LM, Talts, JF, Tryggvason, K, Uitto, J, Virtanen, I, von der Mark, K, Wewer, U, Yamada, Y & Yurchenco, PD 2005, 'A simplified laminin nomenclature', Matrix Biology, vol. 24, no. 5, pp. 326-332. https://doi.org/10.1016/j.matbio.2005.05.006

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title = "A simplified laminin nomenclature",

abstract = "A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha5beta1gamma1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of beta chains is named laminin beta-knob (Lbeta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha1L4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered.",

keywords = "Animals, Humans, Laminin, Terminology as Topic",

author = "Monique Aumailley and Leena Bruckner-Tudermann and Carter, {William G.} and Rainer Deutzmann and David Edgar and Peter Ekblom and J{\"u}rgen Engels and Eva Engvall and Erhard Hohenester and Jones, {Jonathan C.R.} and Kleinman, {Hynda K.} and Marinkovich, {M. Peter} and Martin, {George R.} and Ulrike Mayer and Guerrino Meneguzzi and Miner, {Jeffrey H.} and Kaoru Miyazaki and Manuel Patarroyo and Mats Paulsson and Vito Quaranta and Sanes, {Joshua R.} and Takako Sasaki and Kiyotoshi Sekiguchi and Sorokin, {Lydia M.} and Talts, {Jan Fredrik} and Karl Tryggvason and Jouni Uitto and Ismo Virtanen and {von der Mark}, Klauv and U Wewer and Yoshihiko Yamada and Yurchenco, {Peter D.}",

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doi = "10.1016/j.matbio.2005.05.006",

language = "English",

volume = "24",

pages = "326--332",

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T1 - A simplified laminin nomenclature

AU - Aumailley, Monique

AU - Bruckner-Tudermann, Leena

AU - Carter, William G.

AU - Deutzmann, Rainer

AU - Edgar, David

AU - Ekblom, Peter

AU - Engels, Jürgen

AU - Engvall, Eva

AU - Hohenester, Erhard

AU - Jones, Jonathan C.R.

AU - Kleinman, Hynda K.

AU - Marinkovich, M. Peter

AU - Martin, George R.

AU - Mayer, Ulrike

AU - Meneguzzi, Guerrino

AU - Miner, Jeffrey H.

AU - Miyazaki, Kaoru

AU - Patarroyo, Manuel

AU - Paulsson, Mats

AU - Quaranta, Vito

AU - Sanes, Joshua R.

AU - Sasaki, Takako

AU - Sekiguchi, Kiyotoshi

AU - Sorokin, Lydia M.

AU - Talts, Jan Fredrik

AU - Tryggvason, Karl

AU - Uitto, Jouni

AU - Virtanen, Ismo

AU - von der Mark, Klauv

AU - Wewer, U

AU - Yamada, Yoshihiko

AU - Yurchenco, Peter D.

PY - 2005

Y1 - 2005

N2 - A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha5beta1gamma1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of beta chains is named laminin beta-knob (Lbeta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha1L4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered.

AB - A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha5beta1gamma1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of beta chains is named laminin beta-knob (Lbeta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha1L4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered.

KW - Animals

KW - Humans

KW - Laminin

KW - Terminology as Topic

U2 - 10.1016/j.matbio.2005.05.006

DO - 10.1016/j.matbio.2005.05.006

M3 - Journal article

C2 - 15979864

SN - 0945-053X

VL - 24

SP - 326

EP - 332

JO - Matrix Biology

JF - Matrix Biology

IS - 5

ER -

A simplified laminin nomenclature

Abstract

Keywords

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