A simple method to ensure homogeneous drug distribution during intrarenal infusion

Dmitry D Postnov; Max Salomonsson; Charlotte M Sorensen; Olga V Sosnovtseva

doi:10.1152/ajprenal.00417.2016

A simple method to ensure homogeneous drug distribution during intrarenal infusion

Dmitry D Postnov, Max Salomonsson, Charlotte M Sorensen, Olga V Sosnovtseva

Renal and Vascular Research

2 Citations (Scopus)

Abstract

Intrarenal drug infusion plays an important role in renal experimental research. Laminar flow of the blood can cause streaming and inhomogeneous intrarenal distribution of infused drugs. We suggest a simple method to achieve a homogeneous intravascular distribution of drugs infused into the renal artery of anesthetized rats. The method employs a multiple sidehole catheter inserted into the renal artery, which enables an efficient drug mixing with the arterial blood. To verify the efficiency of this method, we use laser speckle imaging and renal artery flowmetry. The results show that, compared with the conventional single-hole catheter, the multiple sidehole catheter provides a more uniform drug distribution and a homogenous vascular response on the surface of the kidney.

Original language	English
Journal	American Journal of Physiology: Renal Physiology
Volume	312
Issue number	3
Pages (from-to)	F543-F548
Number of pages	6
ISSN	1931-857X
DOIs	https://doi.org/10.1152/ajprenal.00417.2016
Publication status	Published - 9 Mar 2017

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title = "A simple method to ensure homogeneous drug distribution during intrarenal infusion",

abstract = "Intrarenal drug infusion plays an important role in renal experimental research. Laminar flow of the blood can cause streaming and inhomogeneous intrarenal distribution of infused drugs. We suggest a simple method to achieve a homogeneous intravascular distribution of drugs infused into the renal artery of anesthetized rats. The method employs a multiple sidehole catheter inserted into the renal artery, which enables an efficient drug mixing with the arterial blood. To verify the efficiency of this method, we use laser speckle imaging and renal artery flowmetry. The results show that, compared with the conventional single-hole catheter, the multiple sidehole catheter provides a more uniform drug distribution and a homogenous vascular response on the surface of the kidney.",

author = "Postnov, {Dmitry D} and Max Salomonsson and Sorensen, {Charlotte M} and Sosnovtseva, {Olga V}",

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T1 - A simple method to ensure homogeneous drug distribution during intrarenal infusion

AU - Postnov, Dmitry D

AU - Salomonsson, Max

AU - Sorensen, Charlotte M

AU - Sosnovtseva, Olga V

PY - 2017/3/9

Y1 - 2017/3/9

N2 - Intrarenal drug infusion plays an important role in renal experimental research. Laminar flow of the blood can cause streaming and inhomogeneous intrarenal distribution of infused drugs. We suggest a simple method to achieve a homogeneous intravascular distribution of drugs infused into the renal artery of anesthetized rats. The method employs a multiple sidehole catheter inserted into the renal artery, which enables an efficient drug mixing with the arterial blood. To verify the efficiency of this method, we use laser speckle imaging and renal artery flowmetry. The results show that, compared with the conventional single-hole catheter, the multiple sidehole catheter provides a more uniform drug distribution and a homogenous vascular response on the surface of the kidney.

AB - Intrarenal drug infusion plays an important role in renal experimental research. Laminar flow of the blood can cause streaming and inhomogeneous intrarenal distribution of infused drugs. We suggest a simple method to achieve a homogeneous intravascular distribution of drugs infused into the renal artery of anesthetized rats. The method employs a multiple sidehole catheter inserted into the renal artery, which enables an efficient drug mixing with the arterial blood. To verify the efficiency of this method, we use laser speckle imaging and renal artery flowmetry. The results show that, compared with the conventional single-hole catheter, the multiple sidehole catheter provides a more uniform drug distribution and a homogenous vascular response on the surface of the kidney.

U2 - 10.1152/ajprenal.00417.2016

DO - 10.1152/ajprenal.00417.2016

M3 - Journal article

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SP - F543-F548

JO - American Journal of Physiology: Renal Physiology

JF - American Journal of Physiology: Renal Physiology

IS - 3

ER -

A simple method to ensure homogeneous drug distribution during intrarenal infusion

Abstract

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