A ribozyme transcribed by a ribozyme

TY - JOUR

T1 - A ribozyme transcribed by a ribozyme

AU - Bentin, Thomas

PY - 2011/4/2

Y1 - 2011/4/2

N2 - Prominent current ideas on how life emerged on Earth include an RNA world hypothesis in which RNA performed informational as well as catalytic functions in the absence of both DNA and protein. Demonstration of a self-replicative system based on ribonucleic acid polymers as both information carriers and catalysts would lend support to such a scenario. A pivotal component of this system would be an RNA dependent RNA polymerase ribozyme capable of replicating its own RNA gene. Recent work from the Holliger group at the Laboratory for Molecular Biology in Cambridge has provided synthetic ribozymes1 that just might foreshadow the future engineering of such self-replicative systems.

AB - Prominent current ideas on how life emerged on Earth include an RNA world hypothesis in which RNA performed informational as well as catalytic functions in the absence of both DNA and protein. Demonstration of a self-replicative system based on ribonucleic acid polymers as both information carriers and catalysts would lend support to such a scenario. A pivotal component of this system would be an RNA dependent RNA polymerase ribozyme capable of replicating its own RNA gene. Recent work from the Holliger group at the Laboratory for Molecular Biology in Cambridge has provided synthetic ribozymes1 that just might foreshadow the future engineering of such self-replicative systems.

U2 - 10.4161/adna.2.2.16852

DO - 10.4161/adna.2.2.16852

M3 - Comment/debate

C2 - 21912725

SN - 1949-095X

VL - 2

SP - 40

EP - 42

JO - Artificial DNA: PNA and XNA

JF - Artificial DNA: PNA and XNA

IS - 2

ER -