A rat model with an isolated bladder in situ

J Thulesen; P S Olsen; J U Grevstad; Steen Seier Poulsen

A rat model with an isolated bladder in situ

J Thulesen, P S Olsen, J U Grevstad, Steen Seier Poulsen

Endocrinology and Metabolism

Abstract

This paper describes our method for producing a rat model with an isolated bladder in situ in which the bladder makes no contact with urine. First, the right kidney was removed, then an external catheter was placed in the right ureter for bladder infusions, and next the left ureter was anatomosed to the proximal part of the descending colon. The animals were treated with antibiotics, and saline was infused daily into the bladder in order to prevent atrophy. This in situ model is considered to be useful in studies investigating the influence of specific compounds, such as carcinogens, on the bladder and its urothelium.

Original language	English
Journal	Surgery Today
Volume	27
Issue number	11
Pages (from-to)	1089-1092
Number of pages	4
ISSN	0941-1291
Publication status	Published - 1997

Keywords

Anastomosis, Surgical
Animals
Colon
Disease Models, Animal
Male
Rats
Rats, Wistar
Ureter
Urinary Bladder
Urography

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title = "A rat model with an isolated bladder in situ",

abstract = "This paper describes our method for producing a rat model with an isolated bladder in situ in which the bladder makes no contact with urine. First, the right kidney was removed, then an external catheter was placed in the right ureter for bladder infusions, and next the left ureter was anatomosed to the proximal part of the descending colon. The animals were treated with antibiotics, and saline was infused daily into the bladder in order to prevent atrophy. This in situ model is considered to be useful in studies investigating the influence of specific compounds, such as carcinogens, on the bladder and its urothelium.",

keywords = "Anastomosis, Surgical, Animals, Colon, Disease Models, Animal, Male, Rats, Rats, Wistar, Ureter, Urinary Bladder, Urography",

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year = "1997",

language = "English",

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journal = "Surgery Today",

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T1 - A rat model with an isolated bladder in situ

AU - Thulesen, J

AU - Olsen, P S

AU - Grevstad, J U

AU - Poulsen, Steen Seier

PY - 1997

Y1 - 1997

N2 - This paper describes our method for producing a rat model with an isolated bladder in situ in which the bladder makes no contact with urine. First, the right kidney was removed, then an external catheter was placed in the right ureter for bladder infusions, and next the left ureter was anatomosed to the proximal part of the descending colon. The animals were treated with antibiotics, and saline was infused daily into the bladder in order to prevent atrophy. This in situ model is considered to be useful in studies investigating the influence of specific compounds, such as carcinogens, on the bladder and its urothelium.

AB - This paper describes our method for producing a rat model with an isolated bladder in situ in which the bladder makes no contact with urine. First, the right kidney was removed, then an external catheter was placed in the right ureter for bladder infusions, and next the left ureter was anatomosed to the proximal part of the descending colon. The animals were treated with antibiotics, and saline was infused daily into the bladder in order to prevent atrophy. This in situ model is considered to be useful in studies investigating the influence of specific compounds, such as carcinogens, on the bladder and its urothelium.

KW - Anastomosis, Surgical

KW - Animals

KW - Colon

KW - Disease Models, Animal

KW - Male

KW - Rats

KW - Rats, Wistar

KW - Ureter

KW - Urinary Bladder

KW - Urography

M3 - Journal article

C2 - 9413068

SN - 0941-1291

VL - 27

SP - 1089

EP - 1092

JO - Surgery Today

JF - Surgery Today

IS - 11

ER -

A rat model with an isolated bladder in situ

Abstract

Keywords

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